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      • KCI등재

        LSKL, a Peptide Antagonist of Thrombospondin-1, Attenuates Renal Interstitial Fibrosis in Rats with Unilateral Ureteral Obstruction

        Xi-sheng Xie,Fei-yan Li,Heng-chuan Liu,Yao Deng,Zi Li,Jun-ming Fan 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.2

        The effects of LSKL, the peptide antagonist of thrombospondin-1 (TSP-1), on renal interstitial fibrosis in rats subjected to unilateral ureteral obstruction (UUO) were investigated. Rats were divided randomly into three groups (n = 20 each): UUO group, sham-operation group and UUO plus LSKL treatment group. Collagen deposition was studied using histopathology and reverse transcription polymerase chain reaction analysis (RT-PCR). TSP-1, transforming growth factor beta 1 (TGF-β1), phosphorylated Smad2 (pSsmad2) and α-smooth muscle actin (α-SMA) in the kidney were measured using immunocytochemistry, western blotting analysis, RT-PCR and enzyme-linked immunosorbent assay. Biochemical analyses in the serum and urine were made. Histopathology showed severe tubular dilatation and atrophy, interstitial inflammation and collagen accumulation after surgery and LSKL significantly inhibited interstitial fibrosis including tubular injury as well as collagen deposition. The protein and mRNA levels of TSP-1 increased notably at different time point and significantly decreased in the presence of LSKL. The expression of TGF-β1 and pSmad2 were upregulated in the obstructed kidney and substantially suppressed by LSKL treatment. Myofibroblast accumulation could be alleviated after administration of LSKL. Biochemical parameters did not show differences among the three groups. As TSP-1 is the major activator of TGF-β1, we demonstrate that LSKL can attenuate renal interstitial fibrosis in vivo by preventing TSP-1-mediated TGF-β1 activation.

      • KCI등재

        A Novel Calibration Method Research of the Scale Factor for the All-optical Atomic Spin Inertial Measurement Device

        Sheng Zou,Xi-Yuan Chen,Hong Zhang,Yao Chen,Jian-cheng Fang 한국광학회 2015 Current Optics and Photonics Vol.19 No.4

        A novel method to measure the scale factor for the all-optical atomic spin inertial measurement device(ASIMD) is demonstrated in this paper. The method can realize the calibration of the scale factor by aself-consistent method with small errors in the quiescent state. At first, the matured IMU (inertialmeasurement unit) device was fixed on an optical platform together with the ASIMD, and it has beenused to calibrate the scale factor for the ASIMD. The results show that there were some errors causingthe inaccuracy of the experiment. By the comparative analysis of theory and experiment, the ASIMD wasunable to keep pace with the IMU. Considering the characteristics of the ASIMD, the mismatch betweenthe driven frequency of the optical platform and the bandwidth of the ASIMD was the major reason. Anall-optical atomic spin magnetometer was set up at first. The sensitivity of the magnetometer is ultra-high,and it can be used to detect the magnetization of spin-polarized noble gas. The gyromagnetic ratio ofthe noble gas is a physical constant, and it has already been measured accurately. So a novel calibrationmethod for scale factor based on the gyromagnetic ratio has been presented. The relevant theoreticalanalysis and experiments have been implemented. The results showed that the scale factor of the devicewas 7.272 V/°/s by multi-group experiments with the maximum error value 0.49%

      • KCI등재

        Determination of Thermal Equilibrium in a Sealed Cell Based on Optical Depth

        Sheng Zou,Hong Zhang,Xi-Yuan Chen,Guang-cun Shan,Wei Quan 한국물리학회 2017 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.70 No.2

        An effective method based on optical depth (OD) is presented to measure thermal equilibrium in a cell. First, the principle of determining the temperature distribution in the cell by using the OD is demonstrated. Subsequently, relevant experiments are carried out. Original experimental results showed that some gradients of OD distributions in the cell at different wavelengths and variations of the OD increased slowly along the direction of motion of the beam at a fixed wavelength. At a wavelength of 766.6839 nm, which is about 7 GHz blue shifted with respect to the potassium resonance, the average value of the OD was about 0.764 and the maximal and the minimum inhomogeneity biases among all location points were about 6.07% and 0.56%, respectively. As for the corresponding wavelengths of 766.67785 nm and 766.73004 nm, some deviations from previous results, which were caused by different absorptions of the alkali-metal atoms at different frequencies of the laser beam, were observed. The nonuniform OD values along the direction of motion of the beam reflected an inhomogeneous distribution of the temperature in the cell, which may have been caused by layout of the oven. When the layout of the oven was modified, comparative experiments comparable to these with the previous layout of the oven demonstrated that the uniformity of the temperature distribution in the cell was improved and that thermal equilibrium time was shorter by about 10 minutes. This method played an important role in determining the thermal equilibrium time in the cell.

      • KCI등재

        Investigation on Machining Characteristic of Pneumatic Wheel based on Softness Consolidation Abrasives

        Xi Zeng,Shi-ming Ji,Ming-sheng Jin,Da-peng Tan,Jue-hui Li,Wen-tao Zeng 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

        In order to improve material removal rate of laser hardening workpiece and also make machining tool suitable for free-form surface,a new method based on the softness consolidation abrasives (SCA) is put forward, which means the abrasives are consolidated onthe outer layer of pneumatic wheel to achieve the softness-machining. Binder selecting test shows that acidic silicone is proved tosuit for consolidating particles in cutting process. Combined with robot, the machining system has been established. The machiningeffects of SCA are investigated when it faces with workpiece of different hardness. According to the Preston predicted model, thesimulation results of stress and velocity are proven by analysis of average roughness in the contact region. The contrastive machiningexperimental results show that SCA can supply high cutting stress for material removal and fit for freeform surface’s machining byself-adjustment of flexible body.

      • KCI등재

        Magnetization Produced by Spin-polarized Xenon-129 Gas Detected by Using All-optical Atomic Magnetometer

        Sheng Zou,Hong Zhang,Xi-yuan Chen,Wei Quan 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.6

        The method to produce spin-polarized xenon-129 gas was based on the method of spin-exchangeoptical pumping (SEOP). The magnetizations produced by the hyperpolarized (HP) xenon-129gas were analyzed from the perspective of theoretical and experimental research. The theoreticalsimulation was based on the conventional Bloch equation. The experimental research was based onmeasurements made by using an all-optical atomic magnetometer. The experimental results agreedwith the theoretical simulated results, which proved that an all-optical atomic magnetometer hadthe ability to measure the magnetic field produced by xenon-129 nuclei in a low external magneticfield. Because the frequency of the nuclear spin precession could be detected precisely, the resultsshowed that the mean measurement error of the gyromagnetic ratio was 1.1 × 10−4 Hz/nT.

      • KCI등재

        Analysis of Pressure Distribution of the Bolted Joints Based on the Finite Element Method

        Sheng-ao Wang,Min Zhu,Fei Wu,Tian-xi Liang,Zhao-qun Shao,Yi-long Liu 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.2

        Bolted joints widely exist in the field of the national defense industry. However, its nonlinear stiffness degradation will occur under tangential load which may lead to the reliability reduction. According to Coulomb friction theory, the pressure distribution is the key in the tangential degradation of bolted joints. Therefore, this paper aims to analyze the pressure distribution of bolted joints. Firstly, we established a threaded bolt model and two simplified models. Secondly, the accuracy of the three models describing the contact area is verified, and the influence of preload and material properties on the contact radius is analyzed. Thirdly, we compared the pressure distribution of the three models, and results show that the smooth bolt model is more suitable for pressure analysis. Finally, the accuracy of several different functions to characterize the pressure distribution of bolted joints is analyzed, and results indicated that the Fernlund function is optimal. This paper provides a feasible simplified bolt model for finite element analysis, and the optimal pressure distribution function can be applied in the tangential stiffness degradation modeling.

      • KCI등재

        Experimental hysteretic behavior of in-plane loaded reinforced grouted multi-ribbed aerated concrete blocks masonry walls

        Sheng-Cai Li,Jian-Xi Dong,Li-Feng Li 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.41 No.1

        In order to analyze the experimental hysteretic behavior of the in-plane loaded reinforced grouted multi-ribbed aerated concrete blocks masonry walls (RGMACBMW), we have carried out the pseudo static testing on the six specimens of RGMACBMW. Based on the test results and shear failure characteristics, the shear force hysteretic curves and displacement envelope curves of the models were obtained and discussed. On the basis of the hysteretic curves a general skeleton curve of the shear force and displacement was formed. The restoring model was adopted to analyze the seismic behavior and earthquake response of RGMACBMW. The deformation capacity of the specimens was discussed, and the formulas for calculating the lateral stiffness of the walls at different loading stages were proposed as well. The average lateral displacement ductility factor of RGMACBMW calculated based on the test results was 3.16. This value illustrates that if the walls are appropriately designed, it can fully meet the seismic requirement of the structures. The quadri-linear restoring models of the walls degradation by the test results accurately reflect the hysteretic behaviors and skeleton curves of the masonry walls. The restoring model can be applied to the RGMACBMW structure in earthquake response analysis.

      • KCI등재

        Transarterial Chemoembolization Using Gelatin Sponges or Microspheres Plus Lipiodol-Doxorubicin versus Doxorubicin-Loaded Beads for the Treatment of Hepatocellular Carcinoma

        Yi-Sheng Liu,Ming-Ching Ou,Yi-Shan Tsai,Xi-Zhang Lin,Chien-Kuo Wang,Hong-Ming Tsai,Ming-Tsung Chuang 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.1

        To retrospectively compare treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) using gelatin sponges or microspheres plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB). A total of 158 patients with HCC received TACE from November 2010 to November 2011 were enrolled in this study, including 64 (40.5%) received TACE with lipiodol-doxorubicin and gelatin sponges (group A), 41 (25.9%) received TACE with lipiodol-doxorubicin and microspheres (group B), and 53 (33.5%) received TACE with doxorubicin-loaded DEB (group C). Tumor response and adverse events (AEs) were evaluated. No significant difference was found at baseline among the three groups. The doxorubicin dosage in group C wassignificantly (p < 0.001) higher compared to the dose used in groups A or B (median, 50 mg vs. 31 mg or 25 mg). Significantly (p < 0.001) more patients in group C achieved complete response compared to those in groups A or B (32.1% vs. 6.3% or 2.4%). Significantly (p < 0.001) less patients in group C had progressive disease compared to those in groups A or B (34.0% vs. 57.8% or 68.3%). Minor AEs were more common in groups A and B compared to group C, with rates of 54.7%, 34.1%, and 5.7%, respectively. In patients with HCC, TACE with DEB offers better safety and efficacy profiles compared to either TACE with gelatin sponges or TACE with microspheres.

      • SCIESCOPUS

        Experimental hysteretic behavior of in-plane loaded reinforced grouted multi-ribbed aerated concrete blocks masonry walls

        Li, Sheng-Cai,Dong, Jian-Xi,Li, Li-Feng Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.41 No.1

        In order to analyze the experimental hysteretic behavior of the in-plane loaded reinforced grouted multi-ribbed aerated concrete blocks masonry walls (RGMACBMW), we have carried out the pseudo static testing on the six specimens of RGMACBMW. Based on the test results and shear failure characteristics, the shear force hysteretic curves and displacement envelope curves of the models were obtained and discussed. On the basis of the hysteretic curves a general skeleton curve of the shear force and displacement was formed. The restoring model was adopted to analyze the seismic behavior and earthquake response of RGMACBMW. The deformation capacity of the specimens was discussed, and the formulas for calculating the lateral stiffness of the walls at different loading stages were proposed as well. The average lateral displacement ductility factor of RGMACBMW calculated based on the test results was 3.16. This value illustrates that if the walls are appropriately designed, it can fully meet the seismic requirement of the structures. The quadri-linear restoring models of the walls degradation by the test results accurately reflect the hysteretic behaviors and skeleton curves of the masonry walls. The restoring model can be applied to the RGMACBMW structure in earthquake response analysis.

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