Rapid Increase in Marrow Fat Content and Decrease in Marrow Perfusion in Lumbar Vertebra Following Bilateral Oophorectomy: An MR Imaging-Based Prospective Longitudinal Study

Yi-Xiáng J Wáng,James F Griffith,Min Deng,David KW Yeung,Jing Yuan 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.1

Bilateral oophorectomy leads to reduced bone mineral density (BMD), and reduced BMD is associated with increased marrow fat and reduced marrow perfusion. Purpose of this study was to investigate how soon these changes occur following surgical oophorectomy. Six patients who underwent hysterectomy and bilateral salpingo-oophorectomy were studied. At baseline, mean patient age was 49.5 years (range: 45–54 years). Third lumbar vertebral body BMD measurement using quantitative CT, marrow fat fraction (FF) using MR spectroscopy and marrow perfusion using dynamic contrast enhanced MRI were conducted immediately prior to surgery and at 3, 9, and 21 months after surgery. Reduced BMD, increased marrow FF, and reduced marrow perfusion occurred synchronously post-oophorectomy. There was a sharp decrease of 12.5 ± 7.2% in BMD (n = 6), a sharp increase of 92.2 ± 46.3% (n = 6) in FF, a sharp decrease of 23.6 ± 3.9% in maximum contrast enhancement (n = 5), and of 45.4 ± 7.7% for enhancement slope (n = 5) during the initial 3 months post surgery. BMD and marrow perfusion continued to decrease, and marrow FF continued to increase at a slower rate during the following 18 months. Friedman test showed a significant trend for these changes (p < 0.05). Bilateral oophorectomy leads to a rapid decrease in lumbar BMD, an increase in marrow fat content, and a decrease in marrow blood perfusion.

Research on Flooding Torrential Rain Caused by Interaction of MCC and Meso-β Scale Convective Cell in China

Jing Xi,Li Mingjuan,Li Qiang,Tu Nini 한국기상학회 2011 한국기상학회 학술대회 논문집 Vol.2011 No.10-2

Universality of Finite-Size Corrections to Geometrical Entanglement in One-Dimensional Quantum Critical Systems

Xi-Jing Liu,Bing-Quan Hu,Sam Young Cho,Huan-Qiang Zhou,Qian-Qian Shi 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.7

Recently, the finite-size corrections to the geometrical entanglement per lattice site in the spin- 1/2 chain have been numerically shown to scale inversely with system size, and its prefactor b has been suggested to be possibly universal [Q-Q. Shi et al., New J. Phys. 12, 025008 (2010)]. As possible evidence of its universality, the numerical values of the prefactors have been confirmed analytically by using the Affleck-Ludwig boundary entropy with a Neumann boundary condition for a free compactified field [J-M. Stephan et al., Phys. Rev. B 82, 180406(R) (2010)]. However, the Affleck-Ludwig boundary entropy is not unique and does depend on conformally invariant boundary conditions. Here, we show that a unique Affleck-Ludwig boundary entropy corresponding to a finitesize correction to the geometrical entanglement per lattice site exists and show that the ratio of the prefactor b to the corresponding minimum groundstate degeneracy gmin for the Affleck- Ludwig boundary entropy is a constant for any critical region of the spin-1 XXZ system with the single-ion anisotropy, i.e., b/(2 log2 gmin) = −1. Previously studied spin-1/2 systems, including the quantum three-state Potts model, have verified the universal ratio. Hence, the inverse finite-size correction to the geometrical entanglement per lattice site and its prefactor b are universal for one-dimensional critical systems.

Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy

Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.

일반논문 : 한,중 양태 의미 실현 양상의 대조 연구 -언어유형론의 관점에서-

장경희 ( Jing Xi Zhang ) 연세대학교 언어정보연구원(구 연세대학교 언어정보개발원) 2015 언어사실과 관점 Vol.35 No.-

Up till now, prevailing contrastive studies on modality between Korean and Chinese have been limited to comparing the grammatical collocations and the modal auxiliary verbs. However, modality is proved to be marked in various ways in many languages. Therefor this paper is based on a contrastive study of modal expressions in Korean and Chinese from a typological perspective, considering that Korean is a agglutinating and Chinese is isolating morphologically and their syntactic structures will also be affected by their typological features. The author collected general and specific characteristics of modal expressions in Korean and Chinese, and aimed to establish a complete modal system for contrastive studies and the corresponding typological reasons.

Computed Tomography Manifestations of Histologic Subtypes of Retroperitoneal Liposarcoma

Lu, Jing,Qin, Qin,Zhan, Liang-Liang,Yang, Xi,Xu, Qing,Yu, Jing,Dou, Li-Na,Zhang, Hao,Yang, Yan,Chen, Xiao-Chen,Yang, Yue-Hua,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Objective: Liposarcoma (LPS) is the most common soft tissue sarcoma and accounts for approximately 20% of all mesenchymal malignancies, often occurring in deep soft tissue of retroperitoneal space. Accurate preoperative diagnosis is therefore necessary. We explored whether computed tomography (CT) could be used to differentiate between the various types of retroperitoneal liposarcoma (RPLS). Method: Forty-seven cases of RPLS, diagnosed surgically and histologically, were analyzed retrospectively. CT features were correlated with postoperative pathological appearance. Results: The study radiologist identified 29, 11, 2, 2 and 3 RPLS as atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL), dedifferentiated liposarcoma (DDL), myxoid/round cell liposarcoma (ML/RCL), pleomorphic liposarcoma (PL) and mixed-type liposarcoma. Analysis of CT scans revealed the following typical findings of the different subtypes of RPLS: ALT/WDL was mainly visible as a well-delineated fatty hypodense tumor with uniform density and integrity margin; DDL was marked by the combination of focal nodular density and hypervascularity. ML/RCL, PL and mixed liposarcoma showed malignant biological behaviour and CT findings need further studies. Conclusions: CT scanning can reveal important details including internal components, margins and surrounding tissues. Based on CT findings, tumor type can be roughly evaluated and biopsy location and therapeutic scheme guided.

H∞ Filtering for Markovian Jump Linear Systems with Uncertain Transition Probabilities

Xi-Kui Liu,Ji-Jing Zhuang,Yan Li 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.7

This paper studies the H∞ filtering problem of stochastic linear systems subject to Markovian jump and multiplicative noise. The transition probabilities are considered to be uncertain. A unified form of filters is constructed for both continuous-time and discrete-time stochastic systems. With the new decoupling technique for the coupling terms between Lyapunov matrices and filtering parameters, sufficient conditions of stochastic stability and H∞ performance of filtering error system are derived. Based on these conditions, the filter is designed with lesscoupling matrices and the filter gain matrices are obtained by calculating a set of linear matrix inequalities. Finally, three examples are presented to test the effectiveness of the obtained method.

Measure Synchronization in a Huygens’s Non-Dissipative Two-Pendulum Clocks System

Jing Tian,ZiChen Chen,HaiBo Qiu,XiaoQiang Xi 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.72 No.2

In this paper, we characterize measure synchronization (MS) in a four-degrees-of-freedom Huygens’s two-pendulum clocks system. The two-pendulum clocks are connected by a massless spring with stiffness constant k. We find that with the stiffness constant k increasing, the coupled pendulums system achieves MS above a threshold value of kc. The energy characteristics of measure synchronization have been discussed, it is found that averaged energy of each pendulum system provide us an easy way to characterize MS transition. Furthermore, we discuss the dependence of the critical value for MS transition on initial conditions and the characteristic parameters of the system.

Mesenchymal Stem Cells on a Decellularized Cartilage Matrix for Cartilage Tissue Engineering

Xi-Fu Zheng,Shi-Bi Lu,Wei-Guo Zhang,Shu-Yun Liu,Jing-Xiang Huang,Quan-Yi Guo 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.3

An ideal scaffold for cartilage tissue engineering should be biomimetic in not only its biochemical composition, but also in the morphological structure of the scaffold. In this study, we fabricated a scaffold with an oriented structure using a nanofibrous articular cartilage extracellular matrix (ACECM), in which the ACECM was used to mimic the biochemical composition and oriented structure of articular cartilage. Histology analysis showed that the scaffold contained cartilage ECM (GAGs and collagen II). Scanning electron microscopy (SEM) indicated that the scaffolds were composed of nanofibers and possessed vertical microtubules. Chondrogenic differentiation-induced mesenchymal stem cells (MSCs) were seeded on the scaffold in vitro. SEM showed that MSCs proliferated well and aligned along the vertical microtubules,which mimicked the orientation of deep zone articular cartilage. A cell proliferation assay and live/dead cell staining demonstrated that the ACECM possessed good cell affinity, which favored cell adherence and proliferation. The MSCs that had been labeled with the fluorescent dye PKH26 and seeded on scaffolds were implanted into nude mice. The differentiated cells/ACECM implants formed cartilage-like tissue 4 weeks after implantation, and stained positive for collagen type II and toluidine blue. In addition,the in vivo fluorescent images verified that the MSCs in the implants were the labeled MSCs. These results demonstrated that the oriented ACECM scaffolds hold great promise for use in cartilage tissue engineering applications.

An improved algorithm for pile damage localization based on complex continuous wavelet transform

Jing-Liang Liu,Cheng-Xu Lin,Xi-Jun Ye,Wen-Ting Zheng,Yong-Peng Luo 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.27 No.3

Since the complex continuous wavelet transform (CCWT) based pile damage detection method is empirical and subjective, an improved algorithm for pile damage localization based on CCWT is proposed by introducing K-means clustering and fast Fourier transform (FFT). In this method, the K-means clustering algorithm is used to accurately calculate the time coordinates of two energy concentrating points caused by the incident and reflected waves, respectively. Meanwhile, FFT is employed to estimate the concerned frequency band of the response signal. Therefore, a specific region in the time frequency plane is defined objectively and it can be used to search the phase angle turning points and localize pile damage. The proposed method is verified by numerical examples of piles with single and multiple damage positions. A parameter analysis is also conducted to investigate how damage depth and damage degree in piles affect the accuracy and effectiveness of the proposed method. The results demonstrate that the proposed method is able to localize a pile with a damage at least 2.5 m away from the pile head when the damage degree is as less as 5%. After that, dynamic tests of an actual square reinforced concrete pile and an actual circular reinforced concrete pile are investigated to verify the application of the proposed method on practical engineering. Although the proposed method is capable of localizing actual piles more accurately than the CCWT method, the problem of interference points needs to be addressed by mutual verification with other pile damage localization methods.