Esculentoside A exerts anti-oxidative stress and anti-apoptotic effects in rat experimental membranous nephropathy by regulating MAPK pathway

Wu Jin,Lei Genping,Wang Ting,Dong Sheng,Zhan Xiaolin 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.3

Background Membranous nephropathy is characterized by deposition of immune complex. The initial inflammatory responses induce cell apoptosis and oxidative injury, thus contributing to the pathogenesis of chronic kidney disease. Esculentoside A exerts anti-inflammatory, anti-apoptotic and anti-oxidant abilities, and protects against acute kidney injury. Objective The renoprotective effect of Esculentoside A on a rat model with membranous nephropathy was investigated in this study. Results Injection of cationic bovine serum albumin promoted the level of 24 h proteinuria, and induced histopathological damage, including glomerular atrophy and thick glomerular basement membrane in the kidney tissues. Intraperitoneal injection with Esculentoside A reduced the level of 24 h proteinuria, and attenuated the pathological damages. Esculentoside A attenuated cationic bovine serum albumin-induced reduction of Bcl-2 protein expression, enhancements in the protein expressions of Bax and cleaved caspase-3. Besides, the enhanced levels of MDA (malondialdehyde) and NO (nitric oxide), and reduced levels of SOD (superoxide dismutase) and GSH (glutathione), in rats with membranous nephropathy were restored by Esculentoside A injection. Moreover, Esculentoside A counteracted with the promotive effects of cationic bovine serum albumin on the protein expressions of phosphorylated JNK (p-JNK), p-ERK1/2 and p-p38. Conclusion The renoprotective effects of Esculentoside A on a rat model with membranous nephropathy was mediated by its anti-oxidant and anti-apoptotic effects through inactivation of MAPKs pathway.

Weighted Sum of Mechanical Stresses as Cost Function for Posture Prediction of 2 - D Load Lifting

Wujin Park,Il - Seok Jung,Jaeho Choe,Eui S. Jung 대한산업공학회 1996 대한산업공학회 추계학술대회논문집 Vol.1996 No.10

Channel Pricing in Lean and Lucrative Markets : Conditions for Uniform Price, Quantity Discounts and Quantity Premiums

Wujin Chu(주우진),Hyunchul Maeng(맹현철),Yunhwa Song(송윤화) 한국유통학회 2009 한국유통학회 학술대회 발표논문집 Vol.2009 No.2

A New Product Risk Model for the Electric Vehicle Industry in South Korea

Wujin CHU,홍용표,Wonkoo PARK,임미진,Mee Ryoung SONG 한국유통과학회 2020 유통과학연구 Vol.18 No.9

Purpose: This study examined a comprehensive model for assessing the success probability of electric vehicle (EV) commercialization in the Korean market. The study identified three risks associated with successful commercialization which were technology, social, policy, environmental, and consumer risk. Research design, methodology: The assessment of the riskiness was represented by a Bayes belief network, where the probability of success at each stage is conditioned on the outcome of the preceding stage. Probability of success in each stage is either dependent on input (i.e., investment) or external factors (i.e., air quality). Initial input stages were defined as the levels of investment in product R&D, battery technology, production facilities and battery charging facilities. Results: Reasonable levels of investment were obtained by expert opinion from industry experts. Also, a survey was carried out with 78 experts consisting of automaker engineers, managers working at EV parts manufacturers, and automobile industry researchers in government think tanks to obtain the conditional probability distributions. Conclusion: The output of the model was the likelihood of success – expressed as the probability of market acceptance – that depended on the various input values. A model is a useful tool for understanding the EV industry as a whole and explaining the likely ramifications of different investment levels.

Strategic Globalization Performance of JDS

Wujin CHU 한국유통과학회 2023 International Forum on Business Convergence (IFBC) Vol.2023 No.-

시나리오기법 및 선택실험법 기반 한국 전기차 시장 수요예측 연구

주우진(Wujin Chu),임미자(Meeja Im) 한국경영과학회 2018 한국경영과학회지 Vol.43 No.4

This study presents a scenario-based, long-term forecasting model of electric vehicle (EV) sales. A simulated choice experiment using the multinomial hybrid choice model was estimated, where consumer utility was dependent on vehicle type, total cost of ownership (TCO), and personal variables. Results show that lower TCO, lower range-anxiety, and greater environmental concern lead to greater choice probability for EVs. Using the parameters of the TCO variable and the intercept, an initial probability of choosing an EV over an internal combustion engine car was derived. To this initial estimate, macro factors were incorporated, including charging infrastructure, oil prices, battery technology, and government incentives. Charging infrastructure was modeled as the convenience factor; battery technology and government incentives were modeled as affecting vehicle costs; and oil prices as affecting the operating cost. Based on long-term changes in the macro factors, three scenarios were selected: the reference scenario, the low-battery cost scenario, and the high oil price scenario. The forecasting model shows that long-term changes in oil prices are much more important than long-term changes in battery cost in terms of determining the adoption of electric vehicles. This is because fuel cost, over time, has a bigger impact on TCO, whereas the importance of battery prices on TCO decreases. Results also indicate that convenience is the main inhibitor of EV adoption, implying that the government’s policy should transition from providing cash-back incentives to building better charging infrastructure.

전기차 구매의사 영향요인에 대한 문헌 리뷰 및 실증분석: 소비자 심리적 특성 변인의 영향을 중심으로

주우진 ( Chu Wujin ),임미자 ( Im Meeja ),송미령 ( Song Mee Ryoung ) 한국소비자학회 2017 소비자학연구 Vol.28 No.6

전기차 소비 확산을 위해서는 전기차 구매에 영향을 미치는 요인은 무엇인지, 소비자들이 전기차를 어떻게 지각하고 있는 지에 대한 이해가 필요하다. 본 연구는 먼저 전기차 구매의사 영향요인에 대한 기존 문헌을 리뷰한 후에 한국 소비자들 565명을 대상으로 실증분석을 하였다. 전기차 구매에 영향을 미치는 요인, 특히 소비자의 심리적 특성의 영향 요인인 개인의 차에 대한 인식, 친환경성향, 혁신성향, 주행거리불안, 전기차에 대한 주관적 지식 수준이 구매의도에 미치는 영향을 리뷰하고 분석하였다. 실증 연구결과, 한국의 소비자들은 연령이 높을수록, 교육수준이 높을수록, 소득수준이 높을수록 전기차 구매의사가 높았으며, 성별은 유의한 차이가 없었다. 심리적 특성에서는 친환경성향이 높을수록, 혁신성향이 높을수록, 전기차에 대한 주관적으로 느끼는 지식수준이 높을수록, 전기차 구매의사가 높았다. 또한 친환경성향과 혁신성향은 높은 상관관계를 가지는 것으로 나타났다. 주행거리불안이 높을 수록 전기차 구매의사는 낮았지만, 주행거리불안이 현재 사용차량의 일일사용시간 및 연간사용량과는 무관하다는 결과를 놓고 볼 때 주행거리불안이 객관적 실체보다는 정서적 예측 오류일 수 있음을 시사한다. 본 연구는 한국 시장에서 전기차 구매의사에 영향을 미치는 심리적 특성 변수들의 영향을 분석하였다는 점에서 그 이론적 공헌이 있다. In order to increase consumption of electric cars, it is necessary to understand what factors affect the purchase of electric cars and how consumers perceive electric cars. This study first reviewed existing literature on the influence factors of electric vehicle purchase intention, and then conducted an empirical analysis of 565 Korean consumers. The effect of perception of a car’s functions, environmental concern, consumer innovativeness, range anxiety, and knowledge level on purchase intention was studied. Results of the empirical study show that age, income and education level have a positive influence on purchase intention of electric cars, while gender did not show any effect. With respect to psychological characteristics, the study reveals that environmental concern, consumer innovativeness, and knowledge on electric cars have a positive influence on the purchase intention of electric cars. Also, it was found that consumers’ environmental concern and innovativeness have high correlation. Finally, it is shown that predicted range anxiety is deemed higher when compared to the actual usage behavior, suggesting a failure of affect forecasting. This study has contributed to the theoretical contribution in analyzing the influence of psychological characteristics that affect the intention to purchase electric cars in the Korean market.

대형할인점과 공급업체의 협력-상생 가능성에 대한 이론적 고찰

주우진(Chu Wujin),김현식(Kim Hyunsik) 한국유통학회 2007 流通硏究 Vol.12 No.5

소수의 대형할인점이 체인화, 대형화 등을 통해 구매협상력을 강화하고 경제 전체에서 차지하는 비중이 지속적으로 증가하는 소매과점화현상은 중소형 공급업체 등 수직적 거래의 상대에게 다양한 압박 요인으로 작용하고 있다. 이에 본 연구에서는 정책적 시사점을 이끌어내기 위해 국내외 관련문헌에 대한 조사를 통해 소매과점화 현상이 공급업체와 소비자에 미치는 효과의 실태를 확인해보고, 대형할인점과 공급업체의 협력-상생 가능성을 이론적으로 모색해보았다. 본 연구의 체계는 다음과 같다. 우선 §1에서 소매과점화 현상에 대한 문제제기를 한 후, §2에서 관련 연구 문헌에 대한 문헌연구를 통해 소매과점화 현상에 대한 사실관계의 이해를 시도하고, §3에서 갈등이론과 협상이론을 통해 협력-상생의 가능성을 모색해본 후, §4에서 정책적 시사점과 연구의 한계점 및 향후 연구방향에 대해 논하였다. 본 연구의 결론은 다음과 같다: 첫째, 소매과점화현상이 공급업체의 성과를 악화시키고 사회후생을 악화시킬 것이라는 우려는 근거가 약하다. 지나치지 않을 경우, 대형할인점의 협상력 증대는 이중마진을 축소시켜 경로 전체 파이를 증대시킴으로써 공급업체의 이익도 증가시킬 수 있다. 둘째, 소매과점화에 의해 대형할인점 협상력이 증대되는 환경 속에서도 대형할인점과 공급업체 간 협력-상생의 가능성은 분명히 존재한다. 셋째, 대형할인점과 공급업체는 상호간 이해의 조화성이 높은 문제를 개발, 선택, 집중함으로써 협력-상생을 이끌어내는 것이 바람직하다. Retailing is getting more concentrated over time and retailer power is on the increase. This phenomenon provoke gloomy forecast with respect to the welfare of other players such as suppliers, consumers. We investigate the following issues through a wide range of theoretical literature review : (1) Does the retailing concentration really cause serious damage to suppliers' welfare?, (2) Is there any possibility for retailer and supplier to collaborate?, (3) If collaboration is theoretically possible, what should retailer and supplier do? Also, we proceed some discussion about managerial and theoretical implications based on the results of these investigations. Our findings are as following. Firstly, there is no strong support for deterioration of suppliers' and consumers' welfare due to the retailing concentration. On the contrary, increase of retailer's bargaining power, in some context, may increase suppliers' welfare because it may enlarge total profit of the channel through decrease of double margin. Secondly, from the standpoint of bargaining theory, there exists apparent possibility for collaboration between retailer and suppliers under ongoing retailing concentration. Thirdly, retailer and supplier should select and concentrate on the issues with common interests for successful collaboration between them.

Emotional and Cognitive Determinants of Retail Salespersons’ Emotional Labor and Adaptive Selling Behavior

Joonhwan KIM(Joonhwan KIM),Wujin CHU(Wujin CHU),Sungho LEE(Sungho LEE) 한국유통과학회 2022 유통과학연구 Vol.20 No.9

Purpose: The role of salespersons' emotions in effective selling behavior garners attention among scholars and practitioners. Previous studies have investigated the effects of emotional intelligence and emotional labor on sales success separately. However, to understand the whole process, the relationships among salespersons’ cognition, emotions, and behaviors should be considered simultaneously. Accordingly, we uniquely examined how salespersons’ emotional intelligence (emotional antecedent) and customer orientation (cognitive antecedent) influence their emotional labor (deep acting vs. surface acting), adaptive selling behavior, and the selling results in the retail environment. Research design, data, and methodology: To improve methodological rigor, we used the dyadic approach. We measured 182 salespersons’ emotional intelligence, customer orientation, and emotional labor, and 364 customers assessed the salespersons' adaptive selling behavior and selling results in the insurance and duty-free department retailing sectors. Result: The findings suggest that salespersons' customer orientation and emotional intelligence relate to deep-acting of emotional labor, affecting their adaptive selling behavior and relationship quality with customers. Conclusions: As for managerial implications, sales managers may well consider emotional intelligence levels when selecting salespersons in the retail industry. Additionally, practical training programs are required to cultivate customer orientation, emotional intelligence, and deep acting while performing emotional labor.

Hypoplasia of the Left Portal Vein Territory of the Human Liver: A Case Study

ChangHoSong,Zhe-WuJin,Yong-HyunCho,GenMurakami,MooSamLee,Eui-HyeogHan,Baik-HwanCho 대한의학회 2003 Journal of Korean medical science Vol.18 No.6