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Sang-Mok Kim,Wootack Rhee,Seong-Il Ha,Jae-Hyeon Lim,Il-Tae Jang 대한척추신경외과학회 2014 Neurospine Vol.11 No.4
Objective: Using alendronate after spinal fusion is a controversial issue due to the inhibition of osteoclast mediated bone resorption. In addition, there are an increasing number of reports that the endplate degeneration influences the lumbar spinal fusion. The object of this retrospective controlled study was to evaluate how the endplate degeneration and the bisphosphonatemedication influence the spinal fusion through radiographic evaluation. Methods: In this study, 44 patients who underwent single-level posterior lumbar interbody fusion (PLIF) using cage were examined from April 2007 to March 2009. All patients had been diagnosed as osteoporosis and would be recommended for alendronate medication. Endplate degeneration is categorized by the Modic changes. The solid fusion is defined if there was bridging bone between the vertebral bodies, either within or external to the cage on the plain X-ray and if there is less than 5° of angular difference in dynamic X-ray. Results: In alendronate group, fusion was achieved in 66.7% compared to 73.9% in control group (no medication). Alendronate did not influence the fusion rate of PLIF. However, there was the statistical difference of fusion rate between the endplate degeneration group and the group without endplate degeneration. A total of 52.4% of fusion rate was seen in the endplate degeneration group compared to 91.3% in the group without endplate degeneration. The endplate degeneration suppresses the fusion process of PLIF. Conclusion: Alendronate does not influence the fusion process in osteoporotic patients. The endplate degeneration decreases the fusion rate.
Intranasal Administration Model for Evaluating Protection Against Influenza Virus in Mice
Soo-Won Choi,Ha-Na Youn,Wootack Hong,Jae-Keun Park,Seong-Su Yuk,Jung-Hoon Kwon,Jin-Yong Noh,Jung-Sun Kang,Kyung-Jin Cho,Jeoung-Jin Ryu,Joong-Bok Lee,Seung-Yong Park,In-Soo Choi,Sang-Won Lee,Chang-Seon 대한미생물학회 2015 Journal of Bacteriology and Virology Vol.45 No.1