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Streptococcus anginosus 균혈증에 동반된 상완 골수염 및 주변부 연조직 농양 1예
한우진,조문숙,이정현,안홍대,윤규현,서종구,김진용,김수연,박윤수,서일혜,조용균 대한감염학회 2008 감염과 화학요법 Vol.40 No.5
Streptococcus anginosus is a normal flora found in multiple body sites and belongs to the Streptococcus milleri group, It has often been associated with pyogenic infection, such as periodontitis, endocarditis, pulmonary abscess and abdominal or cerebral abscess. Also uncommonly, it can cause osteomyelitis. A 42-year-o1d man was admitted due to gastric ulcer perforation. At 12th hospital day, left humeral osteomyelitis and soft tissue abscess developed, Streptococcus anginosus grew in blood culture, He was treated with intravenous penicillin and surgical debridement of the necrotic tissue which lead to a satisfactory result. We report a rare case of Streptococcus anginosus-induced humeral osteomyelitis and soft tissue abscess.
성인에서 Mycoplasma pneumoniae 페렴과 동반된 Stevens-Johnson 증후군 1예
이정현,엄영실,한우진,윤규현,이서영,서종구,김진용,김수연,박윤수,서일혜,조용균 대한감염학회 2008 감염과 화학요법 Vol.40 No.6
Stevens-Johnson syndrome is an acute mucocutaneous syndrome that is related to drugs and infections. Mycoplasma pneumonias infection is known as one of the causes of Stevens-Johnson syndrome in children and young adults, In Korea, Mycoplasma pneumoniae infection is rarely reported as a cause of Stevens-Johnson syndrome in adults. We report a case of Stevens-Johnson syndrome associated with Mycoplasma pneumoniae pneumonia in an adult patient. A 34-years old woman was admitted to our hospital and was diagnosed with mycoplasma pneumonia. At the time of admission, she had hemorrhagic crusts on her lips. On the 2nd day of admission, target lesions also developed on her skin. We diagnosed her disease as Stevens-Johnson syndrome associated with Mycoplasma pneumoniae pneumonia. She completely recovered from pneumonia and Stevens-Johnson syndrome after treatment with antibiotics and conservative management.
Evidence for Essential Histidine(s) in γ-Glutamyl Transpeptidase from Rat Kidney
Lee, Woo-Yiel,Kim, Soo-Ja 慶熙大學校 1988 論文集 Vol.17 No.-
쥐 신장에서 분리한 Υ-glutamyl transpeptidase는 중성 조건하에서 diethyl pyrocarbonate에 의해 빠르게 비활성화 되었으며, 이 반응의 2차 반응속도 상수는 3.8M M^-1S^-1였다. 이 비활성화 반응은 파장 240nm 에서 휴광도의 증가를 초래하며 기질인 glycylglycine의 존재하에서는 비활성화 반응속도가 크게 감소하였다. 또한 반응속도론지 상수 Vm/Km의 수소 이온 농도 효과로부터 이 효소분자의 한 기능적 이온화기의 pK_a가 7.1로 나타났으며 이들 결과들은 diethyl pyrocarbonate에 의해 변형된 가능기는 pK_a가 7.1인 histidine 잔기이며, 이 잔기는 이 효소의 촉매적 기능에 관여되는 것으로 추정된다.
The Inhibitory Effect of Prunioside A Acyl Derivatives on NO Production in RAW 264.7 Cell
Lee, Woo-Yiel,Kim, Byung-Hee,Lee, Young-Hang,Choi, Han-Gil,Jeon, Byung-Hun,Jang, Seon-Il,Kim, Young-Jun,Chung, Hun-Taeg,Kim, Young-Soon,Chai, Kyu-Yun Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.10
Prunioside A is a unique, highly oxidized monoterpene glycoside isolated from the methanol extract of Spiraea prunifolia var. Simpliciflora's root. The ester derivatives were synthesized from the hydrolyzed compounds of prunioside A by ${\beta}$-glucosidase. The derivatives showed suppressive effects on the generation of nitric oxide in murine machrophage-like RAW 264.7 cells stimulated by lipopolysaccharide and interferon- ${\gamma}$.
S-663 Highly Efficient Colorimetric Allergy Detection Based on Hierarchically-structured Nanozymes
( Jung Woo Shim ),( Sang Min Lee ),( Ho Yun Shin ),( Seongyeon Cho ),( Yiel Hea Seo ),( Yong Kyun Cho ),( Moon Il Kim ),( Sang Pyo Lee ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Nanozymes, nanomaterials with enzyme-like characteristics, have recently attracted a significant attention due to their potentials to overcome the intrinsic limitations of natural enzymes, such as low stability in harsh conditions (temperature and pH) and relatively high costs for preparation, purification, and storage. In this study, we report a highly efficient colorimetric allergy detection system by employing hierarchically-structured platinum nanoparticles (H-Pt NPs) as peroxidase mimetics. H-Pt NPs were conjugated to an antibody for detecting immunoglobulin E (IgE) analytes, which are the representative markers to diagnose allergy, and successfully integrated into the conventionally used allergy diagnostics, ImmunoCAP diagnostic test (Phadia, Uppsala, Sweden). Using this strategy, total and specific IgE were detected in a 10 min time period at room temperature with high specificity and sensitivity. The high catalytic activity and stability could allow the H-Pt NPs to replace conventional peroxidase-based immunoassay systems as part of new, rapid, robust, and convenient assay systems which can be widely utilized for the identification of clinically important target molecules.
BISDN ATM 네트워크환경에서의 예방 제어 기법을 사용한 과잉밀집 제어
곽귀일(Kwi-Yiel Kwak),최우진(Woo-Jin Choi),송주석(Joo-Seok Song) 한국정보과학회 1991 한국정보과학회 학술발표논문집 Vol.18 No.2
BISDN에서는 전송모드로서 ATM(Asynchronous Transfer Mode)를 사용한다. ATM은 데이타를 셀 단위로 나누고 셀 헤더에 있는 레이블과 호출을 연관시키는 방법으로서 전송률을 갖는 트래픽과 버스티한 트래픽을 지원하는데 융통성을 제공한다. 그러나 ATM 네트워크에서 다양한 요구사항을 갖는 서비스들을 지원하기 위해서는 아직도 해결되어야할 여러가지 문제점들이 있다. 본 논문에서는 BISDN ATM 환경에서의 과잉밀집 제어를 위한 기법을 제안하고 수학적 분석을 통해 매개변수들 간의 관계를 결정짓는다. 여기서 제안한 과잉밀집 제어 기법은 ATM 네트워크내에서 서비스되는 트래픽을 세가지로 분류하고 가상회선 단계와 패킷 단계로 구분해서 과잉밀집을 제어한다. 본 논문에서는 음성 트래픽과 같은 멀티플렉싱이 가능한 트래픽에 요구량보다 작은 대역폭을 할당하고 오버플로우시 적응성있게(adaptive) 처리할 수 있는 기법을 제안했다.
Addition of α,α-Difluoroiodomethyl Ketones to Alkenes with a Copper Catalyst
Kwak, Kyung-Chell,Lee, Woo-Yiel,Zheshan, Quan,Lee, Young-Hang,Yun, Young-Gab,Kwak, Gyu-Beum,Chung, Hun-Taeg,Kwon, Tae-Oh,Chai, Kyu-Yun Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.1
The addition reactions of $\alpha$,$\alpha$-difluoroiodomethyl n-butyl ketone, α,α-difluoroiodomethyl cyclohexyl ketone, or $\alpha$,$\alpha$-difluoroiodomethyl phenyl ketone to alkenes were successfully accomplished in good yields in the presence of copper powder. The reaction was also applicable to alkenes containing a variety of functional groups such as ester, trimethylsilyl, or ether group. Acetonitrile was determined to be the best solvent in the present study and the reaction was performed at 55 ${^{\circ}C}$ for 15-22 h. This reaction provides a new, efficient and general method for the synthesis of $\alpha$,$\alpha$-difluoro functionalized ketones.
Addition of α,α-Difluoroiodomethyl Ketones to Alkenes with a Copper Catalyst
Kyung Chell Kwak,Woo-Yiel Lee,Quan Zheshan,Young Hang Lee,Young-Gab Yun,Gyu Beum Kwak,Hun-Taeg Chung,Tae-Oh Kwon,Kyu Yun Chai* 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.1
The addition reactions of α,α-difluoroiodomethyl n-butyl ketone, α,α-difluoroiodomethyl cyclohexyl ketone,or α,α-difluoroiodomethyl phenyl ketone to alkenes were successfully accomplished in good yields in the presence of copper powder. The reaction was also applicable to alkenes containing a variety of functional groups such as ester, trimethylsilyl, or ether group. Acetonitrile was determined to be the best solvent in the present study and the reaction was performed at 55 oC for 15-22 h. This reaction provides a new, efficient and general method for the synthesis of α,α-difluoro functionalized ketones.