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Short-Term Study on the Effects of Rosemary on Cognitive Function in an Elderly Population
Andrew Pengelly,James Snow,Simon Y. Mills,Andrew Scholey,Keith Wesnes,Leah Reeves Butler 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.1
Rosemary (Rosmarinus officinalis L.) has traditional reputations that justify investigation for a potential role in reducing widespread cognitive decline in the elderly. A randomized, placebo-controlled, double-blinded, repeated-measures crossover study was conducted to investigate possible acute effects of dried rosemary leaf powder on cognitive performance. Twenty-eight older adults (mean age, 75 years) were tested using the Cognitive Drug Research computerized assessment system 1, 2.5, 4, and 6hours following a placebo and four different doses of rosemary. Doses were counterbalanced, and there was a 7-day washout between visits. There was a biphasic dose-dependent effect in measures of speed of memory: the lowest dose (750mg) of rosemary had a statistically significant beneficial effect compared with placebo (P= .01), whereas the highest dose (6,000mg) had a significant impairing effect (P< .01). There were significant deleterious effects on other measures of cognitive performance, although these were less consistent. Speed of memory is a potentially useful predictor of cognitive function during aging. The positive effect of the dose nearest normal culinary consumption points to the value of further work on effects of low doses over the longer term.
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