ATM-LAN하에서의 TCP segment 크기와 ATM buffer의 크기에 관한 연구

황영원,김상하 충남대학교 자연과학연구소 1994 忠南科學硏究誌 Vol.21 No.2

This paper presents a simulation study of TCP performance over ATM local area networks in the presence of constant-bit-rate(CBR) and variable-bit-rate(VBR) isochronous traffic. The performance measures considered are TCP cell loss and TCP packet loss, which are related to the buffer size in the ATM switch and the TCP segment size. Our simulation results show the TCP packet loss in the given buffer size of the ATM switch. They also suggest the optimal TCP segment size which support the maximum throughput.

유방암에서 종양의 크기와 액와림프절 전이의 상관성을 근거로 한 액와림프절 절제술의 생략

송근영,조현진,김권천 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Purpose: The aim of this study is evaluation of the relations between axillary lymph node status and tumor size, and then applied the omission criteria of axillary lymph node dissection in early breast cancer. Materials and Methods: We reviewed 110 patients underwent radical mastectomy and axillary lymph node dissection in breast cancer at Chosun university Hospital between Feb. 1996 and Mar. 2003. We evaluated the correlations between clinicopathologic factors, axillary lymph node status, and presence of metastasis. Results: Correlations between clinicopathologic factors and axillary lymph node status were statistically significant (p=0.01). Correlation between locoregional metastasis and distant metastasis and axillary lymph node status was significant (p=0.03). Results from the number of histologically-positive lymph nodes were significant (p=0.02) as that of lymph node status. Conclusions: The rate of axillary lymph node metastasis in Tla breast cancer is minute. And, preoperative evaluations and postoperative routine radiation therapy can control the axillary lymph node metastasis in Tla breast cancer. So, omission of the axillary lymph node dissection in Tla breast cancer may be considerable.

寒冷과 溫熱刺戟을 받은 흰쥐의 體溫과 血淸反應에 對한 實驗的 硏究

朴元煥,崔達永 대한동의병리학회 1989 동의생리병리학회지 Vol.4 No.-

This study was planned to observed the reaction of temperature-variation occurring in a living body received cold stimulus and heat stimulus. The external condition was devised to measure Han-Yol (cold and heart) reaction. According to the type of stimulus-method(cold and heat) rats were divided two groups (C-1ㆍC-2 and H-1ㆍH-1) The change of rectal temperature and transaminase, glucose, alkaline phosphatase, total protein, albumin in blood serum were measured 0, 1, 2, 4, 6 and 8 hours after one hour exposure to cold or heat (C-1, H-1) and immediately after one cold or heat, the stimulus being 1, 2, 3, 5 and 7 hours (C-2, H-2) Their results were as follows : 1) In the rectal temperature, old-stimulus-group showed higher degree compared with heat-stimulus-group. (C-2) group showed higher significance than (C-1) group, and also. (H-1) group showed higher significance than that of (H-1) group. 2) In serm glutamic oxaloacetic transaminase activities, (C-2ㆍH-2) group showed higher significance than (C-1ㆍH-1) group, also (H-1) group showed higher significance than (C-1) group particulary, (C-2ㆍH-2) group showed an especially higher value at 3, 5 hours' stimulus group. serum glutamic pyruvic transaminase activities showed an especially higher value at 2 hour' stimulus of (C-2) group. 3) In variation of glucose level, (H-1) group showed rapidly higher value than (C-1) group, (H-2) group showed an especially higher value at 1 hour' stimulus group. 4) In alkaline phosphate activities, (C-1) group showed an especially higher value at 1 hour' stimulus group, (C-2) group showed rapidly higher significance than (H-2) group. 5) In total protein, (H-1) group (at 0, 1, 6 hours' stimulus) showed higher significance than (C-1) group, (C-2ㆍH-2) group decreased gradually as extension of stimulus hours. 6) In albumin, (C-1) group showed a statistical significance at 8 hours' stimulus, (H-2) group showed higher significance than (C-2) group. Han-Yol(cold and heat) stimulus caused metabolic abnormal stimulation and depression in the body, and the reaction of Han-Yol (cold and heat) stimulus caused relatively variation as resisting power in the body. But, in order to make an indication of Han-Yol (cold and heat) stimulus, continuous study is more necessary.

健脾益氣湯 및 加菱實方의 cyclophosphamide에 依한 副作用 抑制에 關한 實驗的 硏究

崔達永,金俊錡,구입본,朴元煥 대한동의병리학회 1997 동의생리병리학회지 Vol.11 No.1

韓醫學에 있어서 癌의 治療에 대해서는 韓藥을 利用한 抗癌劑의 開發과 아울러 東·西醫學의 結合을 통한 治療 效果의 增大 方向에서 化學療法과 放射線療法의 副作用을 減少시키는 藥劑 및 處方에 대한 硏究가 활발히 진행되어 왔다. 근래 毆陽汝忠은 항암제 부작용 감소를 위한 치법으로 健脾益氣法, 和胃降逆法, 補益氣血法, 調陽肝腎法 등을 제시하였는데, 健脾益氣湯은 이러한 치법에 의거하여 四君子湯에 益氣의 황기, 陳皮와 補心의 速志, 酸棗仁을 가미하여 創方된 것으로 臨床事例分析을 통하여 항암제 부작용으로 인한 胃腸障碍, 骨髓抑制,肝腎障碍, 神經損傷을 개선한다고 보고되었으며, 菱實은 韓國과 中國, 日本 등에서 胃癌이나 胎毒, 酒毒에 使用되고 있다. 이에 著者는 健脾益氣湯 및 加菱實方의 抗癌劑 副作用에 대한 抑制 效果를 實驗的으로 立證하기 위하여 흰쥐에 化學療法劑인 cyclophosphamide를 注射하여 副作用을 誘發시키고, cyclophosphamide 投與 前後 各 5日間 健脾益氣法湯 및 加菱實方을 投與한 다음 GOT, GPT, BUN, creatinine, 白血球數, 赤血球數, 血小板數를 測定하였으며, 腹腔癌을 誘發시킨 雄性 생쥐에 健脾益氣湯 및 加菱實方 投與 5日後 cyclophoshamide를 注射하여 副作用을 誘發시키고 白血球數, 赤血球數, 血小板數를 測定하였다. 健脾益氣湯 및 加菱實方은 cyclophoshamide의 副作用에 대한 抑制 效果가 있는 것으로 사료되어 동서의학의 결합을 통하여 암치료에 유효하게 응용될 수 있을 것으로 기대된다. In order to investigate the effects of Gunbiikgitang and Gunbiikgtangganungsil on reducing side-effects of cyclophosphamide to the rats, and mice which have abdominal tumor after Sarcoma-180 cells were transplanted, cyclophosphomide, the anti-cancer agent, was injected in order to induce the side-effects, and the extract of Gunbiikgitang and Gunbiikgtangganungsil was administrated through mouth from 5 days before the injection to 5 days after the injection, and observe GOT, GPT, BUN, creatine, number of leukocyte, erythrocyte an thrombocyte. The results are summarized as follows: 1. In the effects of the inhibition of side-effects on the liver function, the GOT activity were proved to be reduced by the Gunbiikgitang and Gunbiikgtangganungsil and GPT activity were proved to be reduced by the Gunbiikgitang. 2. In the effects of the inhibition effect on the side-effects on the kidney function, the BUN and creatine remained unchanged in all groups. 3. In the number of leukocyte, erythrocyte and thrombocyte, the sample groups of Gunbiikgitang and Gunbiikgtangganungsil that did not had cancer showed an increase compared with control group. 4. In the number of erythrocyte and thrombocyte, the sample group of Gunbiikgitang and Gunbiikgtangganungsil that had cancer showed an increase compared with control group. while, there was no distinguishable development in the study on the cancer-carrier mice in the number of leukocyte. As the result of above experiment, it is presumed that Gunbiikgitang and Gunbiikgtangganungsil has proven to have inhibitory effect on side-effects of cyclophospnhomide. We can conclude that Gunbiikgitang and Gunbiikgtangganungsil will be useful for cure of the cancer in occidental and oriental medical world.

순/구개열 환자에서의 교정-보철 치험례

장원석,최영철,이긍호 대한소아치과학회 2000 大韓小兒齒科學會誌 Vol.27 No.3

순ㆍ구개열(cleft lip and palate)은 구강악안면 영역에서 가장 빈번하게 발생하는 선천성 기형 중 하나로 유전적, 환경적 요인에 의해 발생된다. 순ㆍ구개열 환자는 입술, 코 등의 기형을 보이며, 치과적 문제점으로 , 이환측 측절치는 결손되어 있거나 과잉치가 존재하고 형태적 이상을 보이는 경우가 많고, 맹출하지 못하지 못하거나 이소맹출을 하게된다. 이른 시기에 수행된 수술의 반흔조직(scar tissue)으로 인하여 상악골 설장의 장애가 발생되어 흔히 골격성 Ⅲ급 부정교합이 야기되기 쉬우며, 섭식장애와 발음장애를 보이기도 한다. 이러한 복잡한 문제로 인하여 여러분야의 전문가들로부터 다양한 관리가 필요하다. 순/구개열(cleft lip and alveolus only)은 악안면 영역에 제한적으로 영향을 미친다. 비이환측은 전방으로 회전되어 수평피개가 증가되고, 이환측은 내측으로 회전되어 견치부에서 end to end 관계, 혹은 반대교합을 보인다. 순/구개열 수술은 이와 같은 문제점 등을 개선시키기 위한 것이며, 상악골의 전후방적 성장에는 큰 영향을 미치지 않는것으로 보고되고 있다. 본 증례는 좌측에 순/구개열을 가진 5세 3개월의 여아로 생후 3개월 및 3세에 두 번의 구순열 봉합 수술을 받았으며, 상악 좌측 유측절치와 영구 측절치가 결손되어 있었고, 다발성 우식증 및 비구누공(oroantral fistula)이 존재하였으며, 골격성3급 부정교합을 보였다. 그러나 본 증례가 지니고 있는 골격성 Ⅲ급 부정교합은 구순열 수술후의 반흔조직에 의한 것은 아닌 것으로 판단되었으며, 환자의 기능과 심미성을 회복하기 위하여 혼합치열기 동안 고정성 교정치료를 시행한 후 보철치료를 시행하여 비구누공을 key and keyway attachment와 Konus crown을 이용한 가철성 obturator로 폐쇄하여 양호한 결과를 보였다. 주요어 : 순/구개열, 교정치료, Obturator Cleft lip and palate is one of the most common congenital defects in oho-maxillo-facial region Because most patients undergo surgical repair in early life. the sagittal jaw relationships used to be deteriorated gradually from palate surgery up to adulthood. Also. the maxillary lateral incisor may be absent or atypical-shaped in the cleft site and may not erupt or erupt ectopically, so multidisciplinary dental cares are needed for cleft lip and palate patients. The effects of the cleft lip and alveolus seem to be limited to that part of the dentofacial complex that surrounds the cleft area. In the maxillary arch, the anterior part of 7he non cleft segment has a tendency to be rotated forward. On the other hand, the cleft segment has a tendency to rotated slightly medially ;hence. the tendency for canines to be edge-to-edge and sometimes in crossbite. Lip and alveolus surgery adoquetely correct these problems, with little untoward effect on the skeletal maxillary-mandible relationships. In this report, the patient has a repaired lip and cleft alveolus on the left side with congenital missing on #62, #22, oronasal fistula. and skeletal class Ⅲ malocclusion which is not affected by lip surgery. Dental treatments for this patient including orthodontic(space supeivision, functional regulator in mixed dentition, fixed therapy in permanent dentition) and prosthodontic(removable obturator with key and keyway attachment and Konus crown) therapy were performed to improve the patient s functions and esthetics.

高脂肪性食餌로 因한 高脂血症 白鼠에 首烏延壽丹이 미치는 影響

金庸柱,최달영,김준기,박원환 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

This study was done in order to investigate the effect of Suoyensudan on hyperlipidemia. Results: 1. The level of serum total cholesterol was decreased with the significance in the sample groups as compared with the control groups. 2. The level of serum HDL-cholesterol was increased with significance in sample groups as compared with the control groups. 3. The level of serum phospholipid was increased with significance in Sample 1 group as compared with Control 1 group, but Sample 2 group did not show significance as compared with Control 2 group. 4. The level of serum β-lipoprotein was decreased with the significance in Control 1 group, but control 2 group did not show significance. 5. Rate of total cholesterol vs. HDL-cholesterol and total cholesterol vs phospholipid were increased in the sample groups as compared with the control groups. Conclusion; It is considered that Suoyensudan respectively had recovering effect on the Hyperlipidemia induced by cholesterol in male rats. So it can be use to prvent and treat hyperlipidemia and related deseases.

痰飮에 應用되는 小調中湯이 高脂血症에 미치는 影響

文濬典,崔達永,朴元煥,尹相柱 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

연구배경 : 최근 우리나라에 있어서도 생활 양식의 서구화로 말미암아 다발하고 있는 각종 현대병의 하나인 고지혈증을 한의학적으로 치료하기 위한 방법론의 개발을 연구목적으로 하여, 한의학의 전통적 병인 개념인 담음이론을 통해 고지혈증의 한의학적 개념을 설명하고, 〈의학입문〉처방인 소조중탕을 통해 치료 약재의 개발 가능성을 실험적으로 규명하고자 한다. 방법 : 실험동물에 cholesterol현탁액을 투여하여 고지혈증을 유발시키면서, 〈의학입문〉에 수재된 소조중탕을 투여하여 혈청지질에 포함되어 있는 total-cholesterol, H. D. L-cholesterol, triglyceride, phospholipid 등의 함량변화를 관찰한다. 결과 : 血淸中 total-cholesterol과 triglyceride含量에 미치는 影響은 對照群에 比하여 매우 顯著한 有意性있는 減少가 나타났으며, 血淸中 H.D.L.-cholesterol과 phospholipid含量에 미치는 影響은 對照群에 比하여 有意性있는 減少가 나타났으며, 血淸中 total cholesterol과 HDL cholesterol의 比率은 對照群에 比하여 有意性이 認定되지 않지만 total cholesterol과 phospholipid의 比率은 對照群에 比하여 有意性이 認定된다. 결론 : 祛痰之劑인 小調中湯은 高脂血症의 改善에 有意性있는 成績을 나타내므로 高脂血症과 痰飮은 相關性이 있으며 脂質代謝異常에 따른 動脈硬化症에도 活用될 수 있는 것으로 思慮된다. In order to study the effects of Xiaotiaozhongtang on hyperlipidemia, white rats were induced by lipid metabolism disorder by the oral-injection of cholesterol. The effects of Xiaotiaozhongtang on lipid in serum were measured by the quantity of total-cholesterol and of H.D.L-cholesterol and of triglyceride and of phospholipid, by the rate of total-cholesterol vs H.D.L-cholesterol and of total-cholesterol vs phospholipid in serum. As a result, we can conclude as follows: 1. Effects of Xiaotiaozhongtang on total-cholesterol and triglyceride levels in serum of cholesterol treated rats were very noticeable. 2. Effects of Xiaotiaozhongtang on H. D. L-cholesterol and phospholipid levels in serum of cholesterol treated rats were noticeable. 3. Effect of Xiaotiaozhogtang on the rate of total-cholesterol vs H. D. L-cholesterol in serum of cholesterol treated rats was unnoticed, but on the rate of total-cholesterol vs phospholipid was noticeable. Thus,as the above-mentioned, on hyperlipidemia, the effects of Xiaotiaozhongtang can be recognized. Secondly, both hyperlipidemia and "phlegm-retention" have correlation each other. In the last place,Xiaotiaozhongtang may be used to artherosclerosis induced by, lipid metabolism disorder, hyperlipidemia.

λ-경쇄형 다발성 골수종 1예

박용관,김태원,장영,김진호,강정원,천영욱,박유환,정춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Multiple myeloma is a disease caused by neoplastic plasma cells that synthesize abnormal amouts of immunoglobulin or immunoglobulin fragments. Light chain myeloma are regarded as a separate category characterized by a more malignant clinical course. Light chain myelomas are said to grow fastest of all and are associated with more osteolytic lesions, more hypercalcemia, and a higher incidence of renal failure and amyloidsis than either the IgG, IgA varienties The authors experienced a case of patients with λ-light chain myeloma. A 43-year-old male patient admitted to our hospital with the chief complaint of both rib and lower back pain. The radiologic findings showed multiple pathologic fracture in ribs. osteolytic lesions in 2nd, 3rd cervical spineimmuture plasma cells. Serum electrophoresis showed normal finding. Urine electrophoresis evealed an M-spike. Urine immunoelectrophoress demonstrated λ-monoclonal protein. With the cycle of melphalan, prednisone and α-interferon chemotherapy improved of pain was observed. So we reported the case with brief review of previous literature.

Antioxidative and Anti-inflammatory Activities of Litsea japonica Leaves

Weon Jong Yoon,Se Chan Kang,Young Min Ham,Kil Nam Kim,Weon Hyuk Yang,Hee Jung Kim,Soo Yeong Park,Yong Hwan Jung 한국응용생명화학회 2010 Journal of Applied Biological Chemistry (J. Appl. Vol.53 No.1

Antioxidative and Anti-inflammatory Activities of Litsea japonica Leaves

( Weon Jong Yoon ),( Se Chan Kang ),( Young Min Ham ),( Kil Nam Kim ),( Weon Hyuk Yang ),( Hee Jung Kim ),( Soo Yeong Park ),( Yong Hwan Jung ) 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.1

We investigated the antioxidative and anti-inflammatory properties of an 80% ethanol extract and solvent fractions of Litsea japonica leaves. The extract and the CH2Cl2, EtOAc, and BuOH fractions showed antioxidant potential, based on radical-scavenging activity. In LPS-stimulated RAW 264.7 cells, the CH2Cl2 fractions inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) production. Additionally, the CH2Cl2 fractions inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. These results show that the CH2Cl2 fractions of L. japonica strongly inhibited the production of NO and PGE2 and the induction of iNOS and COX-2 in LPS-stimulated cells. Thus, we propose that CH2Cl2 fractions may inhibit NO and PGE2 production primarily through the regulation of iNOS and COX-2 gene expression. This study suggests the L. japonica may be a natural source of effective antioxidant and anti-inflammatory agents.