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Wenbing Li,Dong Wan,Guanghua Wang,Kun Chen,Qin Hu,Lulu Lu 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.5
A novel catalyst, Fe3O4 nanoparticle decorated Al-Fe pillared bentonite (Fe3O4/Al-Fe-P-B), was prepared by in situ precipitation oxidization method. The catalyst was characterized by SEM, XRD and Raman spectroscopy. The Fe3O4 nanoparticles mainly exist on the surface or enter into the pore of bentonite, with better dispersing and less coaggregation. The catalytic activity of Fe3O4/Al-Fe-P-B was investigated in the degradation of Orange II (OII) by heterogeneous Fenton-like process. The effects of initial concentration of hydrogen peroxide, catalyst loading, temperature and initial pH on the degradation of OII were investigated. The Fe3O4/Al-Fe-P-B showed higher degradation efficiency of OII than bare Fe3O4 or Al-Fe-P-B in the degradation experiment. The enhanced catalytic activity of Fe3O4/Al-Fe-P-B in heterogeneous Fenton system was due to the synergistic effect between Al-Fe-P-B and Fe3O4. The novel catalyst can achieve solid-liquid separation easily by sample magnetic separation and has a good reusability and stability.
Transcriptional Regulatory Elements in Fungal Secondary Metabolism
Wenbing Yin,Nancy P. Keller 한국미생물학회 2011 The journal of microbiology Vol.49 No.3
Filamentous fungi produce a variety of secondary metabolites of diverse beneficial and detrimental activities to humankind. The genes required for a given secondary metabolite are typically arranged in a gene cluster. There is considerable evidence that secondary metabolite gene regulation is, in part, by transcriptional control through hierarchical levels of transcriptional regulatory elements involved in secondary metabolite cluster regulation. Identification of elements regulating secondary metabolism could potentially provide a means of increasing production of beneficial metabolites, decreasing production of detrimental metabolites, aid in the identification of ‘silent’ natural products and also contribute to a broader understanding of molecular mechanisms by which secondary metabolites are produced. This review summarizes regulation of secondary metabolism associated with transcriptional regulatory elements from a broad view as well as the tremendous advances in discovery of cryptic or novel secondary metabolites by genomic mining.
An analytical model to investigate skidding in rolling element bearings during acceleration
Wenbing Tu 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.8
Skidding, which occurs in rolling element bearings during shaft rotational acceleration, causes wear and incipient failure. This paper presents an analytical model to investigate skidding during rolling element bearing acceleration, taking account of the contact force and friction force between the rolling elements and the races and the cage, gravity, and the centrifugal force of the rolling elements. The Hertzian contact theory is applied to calculate the non-linear contact force. The Coulomb friction law is used to calculate the friction force. All forces above are included in force equilibrium equations to derive the non-linear governing equations of the bearing during acceleration, and are solved using a fourth-order Runge-Kutta algorithm with fixed time step. The proposed model is verified by comparison to other published results and with experimental results. The proposed model can be used to investigate skidding in rolling element bearings during acceleration and the transient motion behavior of rolling elements, and it will lay the theoretical foundations for eliminating skidding in rolling element bearings.
Wenbing Shangguan,Xuyang Lv,Nan Tian 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6
Glioma is the most common brain tumor with a dismal prognosis. While temozolomide (TMZ) based chemotherapy significantly improves survival in glioma patients, resistance against this compound commonly leads to glioma treatment failure. Overexpression of long-noncoding RNA (LncRNA) FoxD2 adjacent opposite strand RNA 1 (FoxD2-AS1) was identified to promote glioma development, but the role in TMZ resistance remains unclear. In this paper, we found that FoxD2-AS1 was overexpressed in recurrent glioma, high FoxD2-AS1 expression was significantly correlated with poor patient outcome. Methylation of O6-methylguanine-DNA methyltransferase (MGMT) is significantly less frequent in high FoxD2-AS1 expression patients. Knockdown of FoxD2-AS1 decreased the proliferation, metastatic ability of glioma cells and promote the sensitivity to TMZ in glioma cells. Furthermore, knockdown of FoxD2-AS1 induced hypermethylation of the promoter region of MGMT. Our data suggested that FoxD2-AS1 is a clinical relevance LncRNA and mediates TMZ resistance by regulating the methylation status of the MGMT promoter region.
Shangguan, Wenbing,Lv, Xuyang,Tian, Nan The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6
Glioma is the most common brain tumor with a dismal prognosis. While temozolomide (TMZ) based chemotherapy significantly improves survival in glioma patients, resistance against this compound commonly leads to glioma treatment failure. Overexpression of long-noncoding RNA (LncRNA) FoxD2 adjacent opposite strand RNA 1 (FoxD2-AS1) was identified to promote glioma development, but the role in TMZ resistance remains unclear. In this paper, we found that FoxD2-AS1 was overexpressed in recurrent glioma, high FoxD2-AS1 expression was significantly correlated with poor patient outcome. Methylation of $O^6$-methylguanine-DNA methyltransferase (MGMT) is significantly less frequent in high FoxD2-AS1 expression patients. Knockdown of FoxD2-AS1 decreased the proliferation, metastatic ability of glioma cells and promote the sensitivity to TMZ in glioma cells. Furthermore, knockdown of FoxD2-AS1 induced hypermethylation of the promoter region of MGMT. Our data suggested that FoxD2-AS1 is a clinical relevance LncRNA and mediates TMZ resistance by regulating the methylation status of the MGMT promoter region.
Wang, Wenbing,Sun, Ying,Song, Lina,Wu, Yan,Wu, Huiling Korean Society of Sericultural Science 2008 International Journal of Industrial Entomology Vol.17 No.1
The caspase family proteins play an important role in programmed cell death (apoptosis). To date, the expression profiles of the caspase family genes in Bombyx mori (Bm) are poorly known. In this study, we examined the expression profiles of two novel Bm caspase family genes (ice-2 and ice-5), the potential change of the mitochondrial membrane and the morphology in Bm cells after stimulation of ultraviolet (UV) irradiation. The results showed the potential change of the mitochondrial membrane occurred at 5 hours after UV irradiation treatment. Analysis of fluorescent quantitative RT-PCR demonstrated that both the ice-2 and ice-5 might be involved in UV induced apoptosis in Bm cells. Notably, after UV irradiating, expression pattern of ice-2 and ice-5 were remarkably different. The ice-2 gene was highly expressed at two time points, 0.5 and 5 hours after UV stimulating, while the expression level of ice-5 only peaked at 5 hours after UV stimulating. It indicated that apoptosis induced by UV irradiation was involved in the mitochondrial pathway and the two isoforms of Bm ice may act but play different role during the apoptosis of Bm cells.
Wang, Wenbing,Song, Zhixiu,Ji, Ping,Wu, Jun,Zhang, Zhifang,He, Jialu,Wu, Xiangfu Korean Society of Sericultural Science 2004 International Journal of Industrial Entomology Vol.9 No.2
Superoxide dismutase (SOD) is an important enzyme which catalyzes superoxide radicals to hydrogen peroxide. A Cu, Zn sod-like gene was found in Bombyx mori nuclear polyhedrosis virus encoding 151 amino acids. To demonstrate its function, a recombinant virus named dsBmNPV with deleted sod gene was constructed. It was discovered that the sod gene was not essential for viral replication. Studies on growth of budded virus in BmN cells and superoxide dismutase and catalase activities in vivo after dsBmNPV infection showed that the titer of dsBmNPV decreased obviously comparing to wild type BmNPV, the sod gene was effective on genomic DNA replication of baculovirus, the peak of SOD activity of silkworm infected with wt-BmNPV appeared between 36 and 48 hrs post infection, and with dsBmNPV, it did not appear. And the changes of CAT activity after infection were similar to SOD activity.
A Simulation Study of Defects in a Rolling Element Bearing using FEA
Yimin SHAO,Wenbing Tu,Fengshou GU 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
An internal impact usually happens when there is a small defect in one part of rolling bearings. The Fault signal from this impact is always masked by different noises such as strong vibrations from other parts and the random noise of instrumentation, which makes it difficult to extract an accurate feature signal for early fault diagnosis. In this paper, a simulation study is conducted using the method of finite element analysis (FEA) to understand the vibration characteristics from the small impact. The vibration responses have been modelled based on a typical bearing assembly. Common faults including outer ring defect, inner ring defect and rolling ball defect are simulated and their vibration responses are compared between different faults and at different locations in the bearing housing. The results obtained have shown that under the same defect size, the vibration from the outer ring is the highest whereas that from the rolling ball is the smallest. In addition the vibration close to the mounting hole attenuates considerably compared to that close to outer ring. These findings provide fundamental information to place vibration sensors and to analyse vibration signals.