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Virtual Memory Systems Should Use Larger Pages rather than the Traditional 4KB Pages
Pinchas Weisberg,Yair Wiseman 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.8
Choosing the best page size for Virtual Memory requires considering several factors. A smaller page size reduces the amount of internal fragmentation. On the other hand, a larger page needs smaller page tables. However, this paper argues that the main reason to prefer a larger page is to increase the virtual to physical translation speed i.e. because the size of a TLB is limited, to facilitate increasing of TLB coverage we have to use larger pages
Nonami, Atsushi,Sattler, Martin,Weisberg, Ellen,Liu, Qingsong,Zhang, Jianming,Patricelli, Matthew P.,Christie, Amanda L.,Saur, Amy M.,Kohl, Nancy E.,Kung, Andrew L.,Yoon, Hojong,Sim, Taebo,Gray, Natha American Society of Hematology 2015 Blood Vol.125 No.20
<P>Oncogenic forms of NRAS are frequently associated with hematologic malignancies and other cancers, making them important therapeutic targets. Inhibition of individual downstream effector molecules (eg, RAF kinase) have been complicated by the rapid development of resistance or activation of bypass pathways. For the purpose of identifying novel targets in NRAS-transformed cells, we performed a chemical screen using mutant NRAS transformed Ba/F3 cells to identify compounds with selective cytotoxicity. One of the compounds identified, GNF-7, potently and selectively inhibited NRAS-dependent cells in preclinical models of acute myelogenous leukemia and acute lymphoblastic leukemia. Mechanistic analysis revealed that its effects were mediated in part through combined inhibition of ACK1/AKT and of mitogen-activated protein kinase kinase kinase kinase 2 (germinal center kinase). Similar to genetic synthetic lethal approaches, these results suggest that small molecule screens can be used to identity novel therapeutic targets in cells addicted to RAS oncogenes.</P>
( Nabil Z. Khan ),( Stefan N. Hamaway ),( Miriam D. Weisberg ),( Andrew R. Horn ),( Rushabh M. Vakharia ),( Afshin E. Razi ) 대한고관절학회 2021 Hip and Pelvis Vol.33 No.4
Purpose: The purpose of this study was to evaluate whether patients undergoing primary total hip arthroplasty (THA) at a higher elevation have higher rates of: 1) in-hospital length of stay (LOS); 2) surgical site infections (SSIs); 3) periprosthetic joint infections (PJIs); and 4) costs. Materials and Methods: The Medicare claims database was used to identify patients who underwent primary THA at an altitude higher than 4,000 feet (ft). High-altitude patients were matched to patients who underwent primary THA at an altitude less than 100 ft, yielding 24,958 and 124,765 patients respectively. Outcomes that were assessed included in-hospital LOS, SSIs, PJIs, and costs of care. A P-value less than 0.001 was considered statistically significant. Results: Patients in the study group had significantly longer in-hospital LOS (4 days vs 3 days, P<0.0001). In addition, patients in the study group had a significantly higher incidence and odds of developing SSIs (1.16% vs 0.86%; odds ratio [OR], 1.34; P<0.0001) and PJIs (0.91% vs 0.58%; OR, 1.56; P<0.0001) within 90-days following the index procedure, compared to matched controls. Higher altitude patients incurred higher day of surgery ($16,139.76 vs $15,279.42; P<0.0001) and 90-day costs ($18,647.51 vs $16,401.62; P<0.0001). Conclusion: This study demonstrated that primary THA procedures performed at an elevation higher than 4,000 ft are associated with longer in-hospital LOS, higher rates of SSIs, PJIs, and costs of care. Orthopedists and other healthcare professionals can use this information to provide adequate education for these patients regarding the potential complications that may occur following their procedure.
Noble gas studies of lunar meteorites MIL 090034, MIL 090036, and MIL 090070
Jisun Park,Keisuke Nagao,Jisu Choi,Jong Min Baek,Changkun Park,Jong Ik Lee,Mi Jung Lee,Laurence E. Nyquist,Gregory F. Herzog,Brent D. Turrin,Akira Yamaguchi,Michael K. Weisberg,Naoki Shirai,Mitsuru Eb 대한지질학회 2018 대한지질학회 학술대회 Vol.2018 No.10