Experimental Study on Sustained-release 5-Fluorouracil Implantation in Canine Peritoneum and Para-aortic Abdominalis

Wei, Guo,Nie, Ming-Ming,Shen, Xiao-Jun,Xue, Xu-Chao,Ma, Li-Ye,Du, Cheng-Hui,Wang, Shi-Liang,Bi, Jian-Wei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Objective: To observe local and systemic toxicity after sustained-release 5-fluorouracil (5-Fu) implantation in canine peritoneum and para-aortic abdominalis and the changes of drug concentration in the local implanted tissue with time. Methods: 300 mg sustained-release 5-Fu was implanted into canine peritoneum and para-aorta abdominalis. Samples were taken 3, 5, 7 and 10 days after implantation for assessment of changes and systemic reactions. High performance liquid chromatography was applied to detect the drug concentrations of peritoneal tissue at different distances from the implanted site, lymphatic tissue of para-aortic abdominalis, peripheral blood and portal venous blood. Results: 10 days after implantation, the drug concentrations in the peritoneum, lymphatic tissue and portal vein remained relatively high within 5 cm of the implanted site. There appeared inflammatory reaction in the local implanted tissue, but no visible pathological changes such as cell degeneration and necrosis, and systemic reaction like anorexia, nausea, vomiting and fever. Conclusions: Sustained-release 5-Fu implantation in canine peritoneum and para-aortic abdominalis can maintain a relatively high tumour-inhibiting concentration for a longer time in the local implanted area and portal vein, and has mild local and systemic reactions. Besides, it is safe and effective to prevent or treat recurrence of gastrointestinal tumours and liver metastasis.

Facility Performance Indexes and Rapid Test Feasibility Evaluation Method of Shaking Tables

Wei Guo,Zhipeng Zhai,Zhiwu Yu,Yan Long 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.7

Shaking table test is widely used as the main experimental approach to evaluate seismic performance of structures, and it usually consumes huge funds and labors. To ensure success of the tests, it is essential to evaluate the feasibility and accuracy before the test is conducted. However, research on test feasibility has rarely been reported. In recent years, complexity of shaking table tests has increased significantly due to the increasing demand of testing facility performance. Hence, feasibility evaluation becomes more and more important. In this paper, main performance indexes of the shaking table facility are expounded. According to the performance indexes of actuator parameters, a rapid feasibility evaluation method is then proposed based on the equilibrium between the facility capacity and the table output demand. Subsequently, applicability of the evaluation method is validated by evaluating the practical tests. The results show that the maximum acceleration targets in horizontal and vertical direction are mutually restrained under threedimensional excitations. For the feasibility evaluation of large-scale model tests, the eccentric and overturning moment of specimen are the main performance control indexes due to their adverse influences on the facility. And the overturn-resistance of shaking table will be enhanced significantly by vertical actuators during the absence of vertical excitations. In the shaking table array test, millimeter-scale relative displacement between tables may lead to accidental damage of the test specimen or not working of the facility when the reinforced concrete foundation crosses the shaking tables. Therefore, attentions should be paid to the design of the test scheme.

Femtosecond Photoelectron Imaging of N2 at 410 nm

Wei Guo,Shanshan Wei,Xingqiang Lu,Li Wang 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.12

We experimentally measure the kinetic energy and angular distributions of photoelectrons of N2 as a function of 410 nm femtosecond laser intensity by using velocity map imaging technique. The strong-field multiphoton ionization of molecules shares many of the characteristics with those of atoms. Electron kinetic energies are nearly independent of laser intensities. The independence suggests that the electron peaks in the photoelectron spectrum actually result from a twostep process, indicative of the occurrence of real population in the intermediate states. The relative amplitudes of electron peaks indicate that in the two-step process, nonresonant population transfer dominates for low intensities, while resonant population transfer dominates for higher intensities.

Prediction of warpage in plastic injection molding based on design of experiments

Wei Guo,Lin Hua,Huajie Mao,Zhenghua Meng 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.4

In terms of injection processing parameters, a mathematical model for prediction of warpage was formulated based on design of experiments (DOE). First, the five most influential parameters were screened by using fractional factorial design (FFD): melt temperature,coolant temperature, injection time, V/P switch over and mold temperature. Second, considering the other four principal processing parameters except the melt temperature, the predicting mathematical model was founded by using central composite design (CCD) of experiments and FE simulation. Finally, the results of statistical analysis were collected from software Moldflow. The results suggested that the mathematical model can be used to predict warpage with adequate accuracy. Hence, it indicated that corrective and iterative design steps can be initiated and implemented for better quality of products without resorting to physical trials in plastics injection mold by using this predicting mathematical model.

Mechanism of Bubble Formation in a Combined In-Mold Decoration and Microcellular Foaming Injection Molding Process

Wei Guo,Bo He,Huajie Mao,Mengying Zhang,Lin Hua,Zhenghua Meng 한국섬유공학회 2019 Fibers and polymers Vol.20 No.7

A combined in-mold decoration and microcellular foaming injection molding process (IMD/Mucell) is proposedto improve the surface quality of foamed parts. Through theoretical inference, the mathematical models of temperature field,velocity profile and forces on bubble were established with combining traditional mathematical models and the different heattransfer coefficient of the mold inner surface. The effects of the non-isothermal mold on the bubble structure and formingprocess of inter bubble were investigated with experiments and numerical simulation. Results showed that the criticalpressure of the cavity existed in the melt filling and bubble expanding stage, and it affected the cells structure obviously at thefilling stage. The lift force took the bubbles to the film side based on the velocity profile of viscous fluid, and maximal bubblewas closer to the transition layer with film due to higher temperature. In the combined process, the evolution rule ofsuperficial bubbles was analyzed, and results showed that the surface quality was improved in the film side.

Fatigue Analysis of 306K Crude Oil Tanker Based on MSC Fatigue

Wei Guo,Dong-Myung Bae,Bo Cao,Da-Long Qi 한국해양공학회 2015 韓國海洋工學會誌 Vol.29 No.6

Fatigue in the metal used as hull material has always been an important issue. The fatigue phenomenongenerally occurs suddenly in a ship hull, and always causesa large number of casualties and economic losses. This paper presents a study of an assessment method for the fatigue life based on Li’s approach using MSC Fatigue. The details of Li’s approach based on MSC Fatigue are provided. Based on the results of this study, it can be concluded that Li’s approach has several advantages: (1) it allows the wide application of different structural details, (2) is easy to use, and (3) provides accurate results. Finally, Li’s approach can be proven to be feasible for a ship’s fatigue analysis.

Seismic control of high-speed railway bridge using S-shaped steel damping friction bearing

Wei Guo,Yang Wang,Zhipeng Zhai,Qiaodan Du 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.30 No.5

In this study, a new type of isolation bearing is proposed by combining S-shaped steel plate dampers (SSDs) with a spherical steel bearing, and the seismic control effect of a five-span standard high-speed railway bridge is investigated. The advantages of the proposed S-shaped steel damping friction bearing (SSDFB) are that it cannot only lengthen the structural periods, dissipate the seismic energy, but also prevent bridge unseating due to the restraint effectiveness of SSDs in the large relative displacements between the girders and piers. This study first presents a detailed description and working principle of the SSDFB. Then, mechanical modeling of the SSDFB was derived to fundamentally define its cyclic behavior and obtain key mechanical parameters. The numerical model of the SSDFB's critical component SSD was verified by comparing it with the experimental results. After that, parameter studies of the dimensions and number of SSDs, the friction coefficient, and the gap length of the SSDFBs were conducted. Finally, the longitudinal seismic responses of the bridge with SSDFBs were compared with the bridge with spherical bearing and spherical bearing with strengthened shear keys. The results showed that the SSDFB can not only significantly mitigate the shear force responses and residual displacement in bridge substructures but also can effectively reduce girder displacement and prevent bridge unseating, at a cost of inelastic deformation of the SSDs, which is easy to replace. In conclusion, the SSDFB is expected to be a cost-effective option with both multi-stage energy dissipation and restraint capacity, making it particularly suitable for seismic isolation application to high-speed railway bridges.

Neurotrophin-4 induces myelin protein zero expression in cultured Schwann cells via the TrkB/PI3K/Akt/mTORC1 pathway

Wei Guo,Yan Li,Chao Sun,Hui-Quan Duan,Shen Liu,Shi-Qing Feng,Yun-Qiang Xu 한국통합생물학회 2017 Animal cells and systems Vol.21 No.2

Myelin formation during peripheral nervous system development, as well as myelin repair after injury and in disease, requires multiple intrinsic and extrinsic signals. Neurotrophin-4 (NT-4) is a member of the neurotrophin family, which regulates the development of neuronal networks by participating in the growth of neuronal processes, synaptic development and plasticity, neuronal survival, and differentiation. However, the intracellular signaling pathways by which NT-4 participates in myelination by Schwann cells remain elusive. In this study, we examined the effects of NT-4 on the expression of compact myelin proteins in cultured Schwann cells. Using real-time quantitative RT-PCR and western blotting, we found that NT-4 could significantly enhance the expression of myelin protein zero (MPZ) but not the expression of myelin basic protein or peripheral myelin protein 22. Further, knockdown of truncated TrkB with small interfering RNA could eliminate the effect of NT-4 on MPZ expression. Moreover, we demonstrated that the NT-4-enhanced MPZ expression depended on Akt and mTORC1 signaling. Taken together, these results suggest that NT-4 binds TrkB to enhance the expression of MPZ in Schwann cells, probably through the PI3K/Akt/mTORC1 signaling pathway, thus contributing to myelination.

SOFTWARE DESIGN FOR A RADIO PAGING SYSTEM

Wei, Guo,Bin, Tan,Mei, Zhang Li 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1

Shanghai 100,000 capacity radio paging system is characterized by multi-functions and high reliability in Stratus fault-tolerant computer. Its system structure and software design are described in this thesis.

Shear strength evaluation of RC solid piers of high-speed railway bridges in China

Wei Guo,Chao Fan,Yao Cui,Chen Zeng,Lizhong Jiang,Zhiwu Yu 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.78 No.4

Piers are the main lateral force-resisting members of high-speed railway (HSR) bridges used in China and are characterized by low axial load ratios, low longitudinal reinforcement ratios, low stirrup ratios, and high shear span ratios. It is well known that flexural, flexural-shear, and shear failures of piers may occur during an earthquake. In this study, a new shear strength model was developed to simulate the seismic failure of HSR solid piers accurately. First, low cyclic-loading test data of solid piers obtained in recent years were collected to set up a database for model verification. Second, based on the test database, the applicability of existing shear strength models was evaluated. Finally, a new shear strength model for HSR solid piers with round-ended cross-sections was derived based on the truss model and ultimate equilibrium theory. In comparison with existing models, it was demonstrated that the proposed model could be used to predict the shear strength of HSR piers more accurately.