Hookworm Infection: A Neglected Cause of Overt Obscure Gastrointestinal Bleeding

Kun-Yan Wei,Qiong Yan,Bo Tang,Shi-Ming Yang,Peng-Bing Zhang,Ming-Ming Deng,Mu-Han Lu 대한기생충학열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.4

Preparation of the polyester/cotton composite yarn with alternating segmented structure and interval color via a promising physical spinning approach

Wei Wei,Qinglun Tang,Hengxing Tang,Jun Chen,Kun Yan,Dong Wang 한국의류학회 2021 Fashion and Textiles Vol.8 No.1

Herein, a novel kind of composite yarn with alternating segmented structure and interval color has been prepared based on a ring spinning approach. By adjusting the relative motion and blend ratio of the colored polyester filament and natural cotton staple fiber in yarn spinning process, a series of composite yarns were designed and prepared with various segmented structure and cyclical change of the distinct colors. The blend ratio was found to strongly influence on the segment frequency and yarn performance, achieving an improved mechanical property and yarn performance. A color systematic analysis indicated that the combination of alternating structural change induced interval color sense and gradient at the merged regions would lead to an enhanced stereoscopic visual effect of the composite yarns. Moreover, the composite yarns were confirmed to have an excellent weavability and able to endow different patterns and visual effects to the textiles. Thus, considering of the above advantages and multifunctionalities, this work should spur great possibilities for dyeing industry with the promising physical spinning method.

Improved Global Maximum Power Point Tracking Method Based on Voltage Interval for PV Array under Partially Shaded Conditions

Kun Ding,Xiang Wang,Quan-Xin Zhai,Jun-Wei Xu,Jing-Wei Zhang,Hai-Hao Liu 전력전자학회 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.4

The power?voltage (P?V) curve of photovoltaic (PV) arrays connected in parallel to bypass diodes would have several local maximum power points (LMPP) under partial shading conditions (PSC). Conventional maximum power point tracking (MPPT) methods fail to search for the global maximum power point (MPP) because the searched peak point may remain at the LMPP on the P?V curve under PSC. This study proposes an improved MPPT algorithm to ensure that PV arrays operate at global maximum power point (GMPP) under PSC. The proposed algorithm is based on a critical study and a series of observations of PV characteristics under PSC. Results show the regularity of voltage interval between LMPPs. The algorithm has the advantages of rapidly reaching GMPP, maintaining stability, and recovering GMPP quickly when the operating condition changes. Simulation and experimental results demonstrate the feasibility of the proposed algorithm.

A Hybrid Optimization Algorithm for Traveling Salesman Problem Based on Geographical Information System for Logistics Distribution

Wei Gu,Yong Liu,Li-Rong Wei,Bing-Kun Dong 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.3

This paper presents a hybrid algorithm for traveling salesman problem. The algorithm is a combination of the genetic algorithm and simulated annealing algorithm; in other words, it is a hybrid algorithm. The combination overcomes the deficiencies of the two algorithms when acting separately. The real distance between customers has been used on the basis of geographical information system (GIS) in order to make the result more suitable in real-life. The algorithm has tested on the examples of international standards. We made a comparison with the result of second nearest neighbor algorithm and genetic optimization algorithm. The test showed that the algorithm proposed in this paper has improved the results.

Discovery of novel glycoside hydrolases from C-glycoside-degrading bacteria using sequence similarity network analysis

Wei Bin,Wang Ya-Kun,Yu Jin-Biao,Wang Si-Jia,Yu Yan-Lei,Xu Xue-Wei,Wang Hong 한국미생물학회 2021 The journal of microbiology Vol.59 No.10

C-Glycosides are an important type of natural product with significant bioactivities, and the C-glycosidic bonds of C-glycosides can be cleaved by several intestinal bacteria, as exemplified by the human faeces-derived puerarin-degrading bacterium Dorea strain PUE. However, glycoside hydrolases in these bacteria, which may be involved in the C-glycosidic bond cleavage of C-glycosides, remain largely unknown. In this study, the genomes of the closest phylogenetic neighbours of five puerarin-degrading intestinal bacteria (including Dorea strain PUE) were retrieved, and the protein-coding genes in the genomes were subjected to sequence similarity network (SSN) analysis. Only four clusters of genes were annotated as glycoside hydrolases and observed in the genome of D. longicatena DSM 13814T (the closest phylogenetic neighbour of Dorea strain PUE); therefore, genes from D. longicatena DSM 13814T belonging to these clusters were selected to overexpress recombinant proteins (CG1, CG2, CG3, and CG4) in Escherichia coli BL21(DE3). In vitro assays indicated that CG4 efficiently cleaved the O-glycosidic bond of daidzin and showed moderate β-D-glucosidase and β-D-xylosidase activity. CG2 showed weak activity in hydrolyzing daidzin and pNP- β-D-fucopyranoside, while CG3 was identified as a highly selective and efficient α-glycosidase. Interestingly, CG3 and CG4 could be selectively inhibited by daidzein, explaining their different performance in kinetic studies. Molecular docking studies predicted the molecular determinants of CG2, CG3, and CG4 in substrate selectivity and inhibition propensity. The present study identified three novel and distinctive glycoside hydrolases, highlighting the potential of SSN in the discovery of novel enzymes from genomic data.

Improved Global Maximum Power Point Tracking Method Based on Voltage Interval for PV Array under Partially Shaded Conditions

Ding, Kun,Wang, Xiang,Zhai, Quan-Xin,Xu, Jun-Wei,Zhang, Jing-Wei,Liu, Hai-Hao The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.4

The power-voltage (P-V) curve of photovoltaic (PV) arrays connected in parallel to bypass diodes would have several local maximum power points (LMPP) under partial shading conditions (PSC). Conventional maximum power point tracking (MPPT) methods fail to search for the global maximum power point (MPP) because the searched peak point may remain at the LMPP on the P-V curve under PSC. This study proposes an improved MPPT algorithm to ensure that PV arrays operate at global maximum power point (GMPP) under PSC. The proposed algorithm is based on a critical study and a series of observations of PV characteristics under PSC. Results show the regularity of voltage interval between LMPPs. The algorithm has the advantages of rapidly reaching GMPP, maintaining stability, and recovering GMPP quickly when the operating condition changes. Simulation and experimental results demonstrate the feasibility of the proposed algorithm.

중국 고대도역의 구조와 이방제의 기원에 관하여

왕유곤 서울대학교 지리교육과 1997 地理敎育論集 Vol.38 No.1

There are three periods in the historical development of Ancient Chinese Cities: Initial, Transitional, and Mature. 1. Initial Period : Xia through the Western Han Dynasty. The development of cities in this period has two specific features: a. The shape of the city is a square or nearly such. Chang An in the West Han Dynasty is a typical example. Square constructions in the Han Dynasty prevailed because the Han people were then enthusiastic generally about the Square Shape. They not only built the city square, but also their underground palaces and tombs. b. Cities in the early Qin began with a palace. The city was built around that. City construction increased during the Qin and Han periods. When Qin came to power they wanted to many palaces were built, e. g. Chang Le Palace, Weiyang Palace, North Palace, Gul Palace, Ming Guang Palace and Jian Zhang Palace. 2. Transitional Period : Eastern Han through Three Kingdoms, Western and Eastern Jin, and Southern and Northern Dynasties. The development of cities in this period has three distinctive features: a. The Ground Area was laid out not as a Square but along a North-South Axis b. The Palace Areas in Eastern Han were reduced to two from the six of the Western Han. c. Li Fang was the smallest unit of a city's divisions. It came into use early in the transitional period. Between Wei, Jin, North and South Dynasties and Sui-Tang, it was called $quot;Li$quot; or $quot;Fang$quot;. Later people called it $quot;Li Fang$quot;. For instance, Li Chang Shou, Ji Yang, Yang Ping and Si Zhong first appeared in the Northern City of Sao Wei ye. 3. Mature Period : Sui-Tang Dynasties. The capital city in this period was magnificent, well-planned and regulated as a whole. a. The Administrative Area was established before the Palace Area, staring in Da Xing City in the Sui Dynasty. b. Li Fang with Scarlet Bird Street along the axis, the whole city was divided into two parts, eastern and western. Each part had 54 rectangular compounds known as Fang.

Synthesis, and antioxidant, thrombin-inhibitory, and anticancer activities of hydroxybenzamide derivatives

Jin-Rui Wei,Kun Liu,Faquan Lin,Chunping He,Xuan Luo,Jiajia Zou,Wei He,Wenqian Nong,Cui-Wu Lin 한국응용생명화학회 2016 Applied Biological Chemistry (Appl Biol Chem) Vol.59 No.2

Four hydroxybenzamide derivatives were synthesized from protocatechuic acid. The antioxidant activities of these derivatives were evaluated in vitro using DPPH radical scavenging and reducing power assays. In addition, these compounds were subjected to a chromogenic thrombin-inhibitory assay using Chromozym-TH as the substrate. The anticancer effects of these derivatives were also investigated using the MTT assay in three human cancer cell lines. Four derivatives exhibited excellent DPPH radical scavenging activity and redox potential. Their highly inhibitory effect against thrombin may allow them to be utilized as novel micromolecule thrombin inhibitors. Furthermore, four derivatives demonstrated different inhibitory activities in three human cancer cell lines but showed minimal harmful effects on normal HUVEC cells. Therefore, hydroxybenzamide derivatives indicate the superior antioxidant, thrombin-inhibitory, and anticancer activities along with the excellent biocompatibility, which have the potential application in therapeutic interventions and disease prevention of cancer, thrombotic diseases, and aging.

Triplet Platinum-based Combination Sequential Chemotherapy Improves Survival Outcome and Quality of Life of Advanced Non-small Cell Lung Cancer Patients

Chen, Li-Kun,Liang, Ying,Yang, Qun-Ying,Xu, Fei,Zhou, Ning-Ning,Xu, Guang-Chuan,Liu, Guo-Zhen,Wei, Wei-Dong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Background: Maintenance chemotherapy is one strategy pursued in recent years with intent to break through the chemotherapy plateau for advanced non-small cell lung cancer (NSCLC). However, given the toxicity, platinum-based combinations are rarely given for this purpose. We carried out the present prospective study of triplet platinum-based combination sequential chemotherapy in advanced NSCLC to investigate if patients could tolerate and benefit from such intensive treatment. Methods: From Dec 2003 to Dec 2007, 190 stage IIIB and IV NSCLC patients in Sun yat-sen University sequentially received the 3 platinum-based combination (TP-NP-GP) treatment (T: paclitaxol175$mg/m^2$ d1; N: vinorelbine25$mg/m^2$ d1 and 8; G: gemcitabine1$g/m^2$ d1 and 8; P: cisplatin20$mg/m^2$ d1-5; repeated every 3 weeks). Patients were followed up to at least 3 years to obtain survival data. Treatment toxicities and the quality of life (QOL) were assessed during the whole treatment. Results: There were 187 patients evaluable. The TP, NP and GP response rates with sequential use were 42.8% (80/187), 41.1% (65/158) and 28.8% (21/73) respectively. Median survival time was 18.2 months and the 1, 2 and 3 year overall survival (OS) rates were 78.7%, 38.5% and 21.3%. Patients receiving > 6 cycles of chemotherapy had significantly longer OS and TTP (MST 25.3 vs. 14.5 months, TTP 15.1 vs. 9.1 months). The QOL on the whole for the patients was improved after chemotherapy. Conclusions: The sequential chemotherapy strategy with triplet platinum-based combination regimens can improve the survival outcome and the quality of life of advanced non-small cell lung cancer patients.

The Key Extraction from Iris Features based on Wavelet Packet

Kun Yu,Juan Wei 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.7

Key extraction from the biometric is a new direction of encryption, which solves the safety problem of key a certain extent. Iris has rich textures, and its generated signature is longer than other biometric, and has unique advantages in term of key extraction. The wavelet packet is used to decompose effective iris region into the three layers. The third diagonal high frequency coefficient is extracted as the iris feature, and the encryption key was randomly generated from iris feature to meet the encryption demand. The United States NIST encryption standard is adopted to test the extracted key, and the experimental results show that through the 7 seed test of NIST, the generated key meets the security of encryption algorithm needs.