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Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity
Wei Zhao,Jian Xin Pu,Xue Du,Yong Zhao,Fei He,Hai Bo Zhang,Yong Bo Xue,Wei Lie Xiao,Han Dong Sun,Ying Li Wu,Guo Qiang Chen 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.12
Three new compounds (1-3), including a neolignan, a triterpenoid, and a diterpenoid, together with twenty known compounds (4-23), were isolated from the aerial parts of Isodon coetsa. Their structures and relative configurations were elucidated on the basis of spectroscopic data. Compounds 1, 3, 5-9, 11-13, 16-17, and 19-23 were evaluated for their cytotoxicity against HT-29, BEL-7402, and SK-OV-3 human tumor cell lines. Compound 7 showed significant inhibitory effects on all three types of cells, with IC50 values of 2.52, 3.06, 2.14 μM, respectively.
Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora
Wei-Lie Xiao,Rui-Rui Wang,Wei Zhao,Ren-Rong Tian,Shan-Zhai Shang,Liu-Meng Yang,Jian-Hong Yang,Jian-Xin Pu,Yong-Tang Zheng,Han-Dong Sun 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.5
This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8) . The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1IIIB induced syncytium formation with EC50 values in the range of 2.26~20.4 μg/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1IIIB inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.
Wei-Lie Xiao,Sheng-Hong Li,Yun-Heng Shen,Xue-Mei Niu,Han-Dong Sun 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
Two new coumarin glucosides, 11-O-β-D-glucopyranosyl thamnosmonin (1) and 12-O-β-D-glucopyranosyl gosferol (2), were isolated from the roots of Angelica apaensis. Their structures were elucidated spectroscopically. Both compounds showed weak inhibitory effects on rabbit platelet aggregation induced by PAF, AA and APD.
Xiao, Wei-Lie,Shen, Yun-Heng,Niu, Xue-Mei,Sun, Han-Dong,Li, Sheng-Hong 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
Two new coumarin glucosides, $11-O-{\beta}-D-glucopyranosyl$ thamnosmonin (1) and $12-O-{\beta}-D-glucopyranosyl$ gosferol (2), were isolated from the roots of Angelica apaensis. Their structures were elucidated spectroscopically. Both compounds showed weak inhibitory effects on rabbit platelet aggregation induced by PAF, AA and APD.
Experimental study of masonry walls strengthened with CFRP
Wei, Chang-Qin,Zhou, Xin-Gang,Ye, Lie-Ping Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.25 No.6
In order to study the ductility and the lateral load carrying capacity of the masonry walls strengthened with CFRPs (Carbon Fiber Reinforced Polymer sheets), three pieces of masonry walls subjected to cyclic loads with low frequency and vertical load of constant amplitude have been tested. Two different strengthening methods have been used. The strengthening efficiency is affected by the strengthening method. A simplified calculation approach has been introduced based on the experimental test results, and the theoretical results agree reasonably well with the experimental results. It is found that the critical loads, the critical displacements, the ultimate loads, the ultimate displacements and the ductile coefficients of the masonry walls strengthened with CFRPs improve remarkably (6%~57%). Therefore, the masonry structures strengthened with CFRPs are of better ductility and of better lateral load carrying capacity than the masonry structures without any strengthening measurements.
Upregulation of STK15 in Esophageal Squamous Cell Carcinomas in a Mongolian Population
Chen, Guang-Lie,Hou, Gai-Ling,Sun, Fei,Jiang, Hong-Li,Xue, Jin-Feng,Li, Xiu-Shen,Xu, En-Hui,Gao, Wei-Shi,Cao, Jian-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Background: The STK15 gene located on chromosome 20q13.2 encodes a centrosome-associated kinase critical for regulated chromosome segregation and cytokinesis. Recent studies have demonstrated STK15 to be significantly associated with many tumors, with aberrant expression obseved in many human malignancies. The purpose of this study was to investigate expression of STK15 in esophageal squamous cell carcinomas (ESCCs) in a Mongolian population. Methods: Two non-synonymous single nucleotide polymorphisms in the coding region of STK15, rs2273535 (Phe31Ile) and rs1047972 (Val57Ile) were assessed in 380 ESCC patients and 380 healthy controls. We also detected STK15 mRNA expression in 39 esophageal squamous cell carcinomas and corresponding adjacent tissues by real time PCR. Results: rs2273535 showed a significant association with ESCC in our Mongolian population (rs227353, P allele = 0.0447, OR (95%CI) = 1.259 (1.005~1.578)). Real time PCR analysis of ESCC tissues showed that expression of STK15 mRNA in cancer tissues was higher than in normal tissues (p = 0.013). Conclusions: Our study showed that functional SNPs in the STK15 gene are associated with ESCC in a Mongolian population and up-regulation of STK15 mRNAoccurs in ESCC tumors compared adjacent normal tissues. STK15 may thus have an important role in the prognosis of ESCC and be a potential therapeutic target.
YUAN CHEN,LI WEI,BO WANG,DAPENG LIU,LAIN-JONG LI,YANHUI YANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2009 NANO Vol.4 No.2
A facile method was developed for in situ formation of Co nanoclusters in sol–gel silica thin films spin-coated on Si wafers. The size and density of Co nanoclusters can be controlled by spin-coating speeds, annealing methods, reduction temperatures under H2, and metal precursor concentrations in tetraethylorthosilicate solutions. The optimized preparation condition, spin-coating speed of 9000 rpm, annealing at 500°C in air followed by reduction at 800°C in H2, resulted in silica films as thin as 60 nm and Co nanoclusters with a mean diameter of 1.5 nm. Morphological and chemical characteristics of thin films and nanoclusters were studied by atomic force microscopy and X-ray photoelectron spectroscopy, respectively. Subsequently, these Co nanoclusters were successfully used to grow SWCNTs by CO decomposition. Film containing Co monometallic clusters produced SWCNTs of 1.3 nm in diameter, whereas film having Co/Mo bimetallic clusters produced SWCNTs of 0.9 nm. This sol–gel approach allowed not only easy catalyst patterning on a thin film but also a fine-tuning of SWCNT properties, e.g., diameter.
Implementation of IMS-based PoC Service with Context-Aware Interaction
Jenq-Muh Hsu,Wei-Bin Lain,Chih-Chuan Chan,Yi-Ming Huang 보안공학연구지원센터 2008 International Journal of Multimedia and Ubiquitous Vol.3 No.4
Push-to-Talk (PTT) is a half-duplex and one-to-many voice group communication. In past decades, PTT service has been widely adopted in various areas, including practical military, police, security, rescue, and emergency radio communication, etc. In addition, PTT service has also annunciated being an IP Multimedia Subsystem (IMS)-based service defined by Open Mobile Alliance (OMA), which is called Push-to-Talk over Cellular (PoC).Context-aware computing derived from the field of ubiquitous computing as a technique for imbuing application services with an awareness of users’ surroundings and situations for achieving transparent interaction. Thus, a user can obtain some reasonable and proper services among context-aware interactions. In this paper we try combine the features of PoC and context-aware service to implement a context-aware PoC service based on the Open IMS core. The context-aware PoC service can be aware to filter context information and to form an applicable PoC session according to the current contexts of participant PoC users. By the way, our implemented context-aware PoC service can be realizedly used to play an applicable IMS application service in the next generation network (NGN).
Wu, Bing-Li,Luo, Lie-Wei,Li, Chun-Quan,Xie, Jian-Jun,Du, Ze-Peng,Wu, Jian-Yi,Zhang, Pi-Xian,Xu, Li-Yan,Li, En-Min Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background: Fascin, an actin-bundling protein forming actin bundles including filopodia and stress fibers, is overexpressed in multiple human epithelial cancers including esophageal squamous cell carcinoma (ESCC). Previously we conducted a microarray experiment to analyze fascin knockdown by RNAi in ESCC. Method: In this study, the differentially expressed genes from mRNA expression profilomg of fascin knockdown were analyzed by multiple bioinformatics methods for a comprehensive understanding of the role of fascin. Results: Gene Ontology enrichment found terms associated with cytoskeleton organization, including cell adhesion, actin filament binding and actin cytoskeleton, which might be related to fascin function. Except GO categories, the differentially expressed genes were annotated by 45 functional categories from the Functional Annotation Chart of DAVID. Subpathway analysis showed thirty-nine pathways were disturbed by the differentially expressed genes, providing more detailed information than traditional pathway enrichment analysis. Two subpathways derivated from regulation of the actin cytoskeleton were shown. Promoter analysis results indicated distinguishing sequence patterns and transcription factors in response to the co-expression of downregulated or upregulated differentially expressed genes. MNB1A, c-ETS, GATA2 and Prrx2 potentially regulate the transcription of the downregulated gene set, while Arnt-Ahr, ZNF42, Ubx and TCF11-MafG might co-regulate the upregulated genes. Conclusions: This multiple bioinformatic analysis helps provide a comprehensive understanding of the roles of fascin after its knockdown in ESCC.