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Wanjoo Chun,Hee Jae Lee,Pil-Jae Kong,Gun Hee Lee,Il-Young Cheong,Haeil Park,Sung-Soo Kim 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.2
Wogonin (5,7-dihydroxy-8-methoxyflavone) has been reported to exhibit a variety of biological properties including anti-inflammatory and neuroprotective functions. In this study, biological activities of diverse synthetic wogonin derivatives have been evaluated in two experimental cell culture models. Inhibitory activities of wogonin derivatives on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV2 microglial cells and on hydrogen peroxide (H2O2)-induced neuronal cell death in SH-SY5Y human neuroblastoma were examined. Wogonin derivatives such as WS2 and WS3 showed more potent suppressive activities on LPS-induced NO production and H2O2-induced cytotoxicity than wogonin itself. In addition, thiol substitution played a minor role in enhancing the activities of the derivatives. These findings may contribute to the development of novel anti-inflammatory and neuroprotective agents derived from wogonin.
Chun Wanjoo,Lee Hee Jae,Kong Pil-Jae,Lee Gun Hee,Cheong Il-Young,Park Haeil,Kim Sung-Soo The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.2
Wogonin (5,7-dihydroxy-8-methoxyflavone) has been reported to exhibit a variety of biological properties including anti-inflammatory and neuroprotective functions. In this study, biological activities of diverse synthetic wogonin derivatives have been evaluated in two experimental cell culture models. Inhibitory activities of wogonin derivatives on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV2 microglial cells and on hydrogen peroxide ($H_{2}O_2$)-induced neuronal cell death in SH-SY5Y human neuroblastoma were examined. Wogonin derivatives such as WS2 and WS3 showed more potent suppressive activities on LPS-induced NO production and $H_{2}O_2$-induced cytotoxicity than wogonin itself. In addition, thiol substitution played a minor role in enhancing the activities of the derivatives. These findings may contribute to the development of novel anti-inflammatory and neuroprotective agents derived from wogonin.
박완주(Wanjoo Park),김병성(B.S. Kim),서동은(Dongeun Seo),김동석(D.S. Kim),이쾌희(K.H. Lee) 한국자동차공학회 2007 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
This paper deals with the subject about car navigation system using augmented reality. This system consists of GPS Receiver, CCD Camera and Digit map. GPS Receiver that used in the experiment is the device that is able to obtain position information. CCD Camera to obtain image information that is equal to driver’s view. We obtain the data of positions in urban area by moving car which has a GPS Receiver. From the obtained data of positions, we transform coordinates for generating the world coordinates. And the data of orientation from GPS Receiver and the data of world coordinate are used to indicate the coordinate of digit map. To correct the error of the data of orientation, we use the data of velocity form GPS Receiver, the orientation of digit map and Lane boundary on image coordinates that is calculated by Lane detection. Finally, we obtain the display augmented by virtual object.
다문화 배경 언어학습자의 과학수업 내 소집단에서의 역할 및 상호작용 양상 탐색
안완주(Ahn, Wanjoo),주혜은(Chu Hye-eun),김호정(Kim, Ho Jung),박희경(Park, Hee Kyung),Sonya Nichole Martin(Martin, Sonya Nichole) 학습자중심교과교육학회 2016 학습자중심교과교육연구 Vol.16 No.6
본 연구의 목표는 다문화 배경을 지닌 언어학습자들이 모델 공동 구성 과학 수업에서 나타내는 학습자 역할과 상호작용 양상을 분석하여 교사교육의 방향을 제시하는데 있다. 중학교 3학년 지구과학 모델 공동 구성수업에 참여한 언어학습자 두 명이 포함된 소집단 구성원 다섯 명을 연구 참여자로 선정하여 학생들의 수업 내 상호 작용을 비디오카메라와 녹음기로 녹화 및 녹음하였고, 수집한 자료를 전사해 분석하였다. 이와 더불어 연구자의 수업 참여관찰과 언어학습자 인터뷰를 바탕으로 소집단 내에서 나타난 언어학습자의 역할을 분석하였으며, 수업 참여 양상을 반 전체 상호 작용과 소집단 상호작용으로 나누어 구체적인 사례와 함께 분석하였다. 분석 결과는 다음과 같다. 첫째, 소집단 내 역할 분석 결과 언어학습자 두 명의 역할은 각각 소집단 내 상호작용에 긍정적인 영향을 주며 모델 공동 구성을 촉진하였다. 둘째, 반 전체 수업 상호작용 분석 결과 언어학습자의 다양한 정의적․인지적 어려움이 관찰되었으나, 소집단 상호작용을 통해 과학 학습에 정의적․인지적으로 기여하고, 구성원들의 도움을 받아 이러한 한계를 극복할 수 있음을 밝혀내었다. 이러한 연구 결과를 바탕으로 언어학습자의 수업 내 긍정적 상호작용에 도움을 주기 위하여 적절한 교사의 개입과 중재 및 이를 위한 교사교육의 필요성을 제언하였다. This research paper aims to analyze the learning experiences of language learners from a multicultural background when co-constructing scientific models in a middle school Earth Science class. This interpretive qualitative research study examines the interactions between students and their teachers and students and their peers to consider the ways that language and social interactions impact on science learning. Our analysis focuses on the activities of five students, including two multicultural students who are not fully proficient in Korean language. Data includes whole-class observations of multiple lessons, video and audio recordings of the whole class and small group interactions, and stimulated recall interviews with the teacher and students. The video and audio recordings were all analyzed and transcribed into text. We viewed the videos and audios and identified examples of interactions in which language or social interactions appeared to impact on the students’ science learning. Using these video clips to stimulate participant recall, we interviewed the teachers and students by asking them to reflect on their observed behaviors and interactions with others. Our analysis revealed that while the language learner students experienced cognitive and affective difficulties during the modeling activities, their peers were able to support their learning by serving as an important resource for language and conceptual learning. At the same time, the language learner students benefited the learning of their native Korean peers by promoting reflective dialogue among their peers, contributing to the production of content knowledge, and offering creative and innovative suggestions for developing their group’s model. However, for such strategies to be successful, teachers need to provide students with clear roles for their participation and to foster positive social interactions among peers. Our findings have implications for teachers’ use of collaborative teaching strategies, such as modeling activities, with language learner students.