Fe@C₂N: A highly-efficient indirect-contact oxygen reduction catalyst

Mahmood, Javeed,Li, Feng,Kim, Changmin,Choi, Hyun-Jung,Gwon, Ohhun,Jung, Sun-Min,Seo, Jeong-Min,Cho, Sung-June,Ju, Young-Wan,Jeong, Hu Young,Kim, Guntae,Baek, Jong-Beom Elsevier 2018 Nano energy Vol.44 No.-

<P><B>Abstract</B></P> <P>Converting unstable earth-abundant group VIIIB transition metals into stable catalysts with high oxygen reduction reaction (ORR) performances remains a critical challenge for electrochemical technologies. Iron (Fe)-nitrogen (N)-carbon (C)-based electrocatalysts have recently demonstrated ORR performances comparable to platinum (Pt)-based catalysts. However, as their poor stability remains a critical issue, which needs to be resolved to satisfy commercial requirements. Here, we describe a methodology for preparing a high-performance and stable Fe-based ORR catalyst. The catalyst was obtained by the <I>in-situ</I> sandwiching of a Fe<SUP>3+</SUP> precursor in a nitrogenated holey two-dimensional network (denoted as C<SUB>2</SUB>N). Reduction of the sandwiched Fe<SUP>3+</SUP> results in the formation of Fe oxide (Fe<SUB>x</SUB>O<SUB>y</SUB>) nanoparticles, which are simultaneously transformed into highly crystalline Fe<SUP>0</SUP> nanoparticle cores, while the C<SUB>2</SUB>N is catalysed into well-defined, encapsulating, nitrogenated graphitic shells (Fe@C<SUB>2</SUB>N nanoparticles) during heat-treatment. The resultant Fe<SUP>0</SUP>@C<SUB>2</SUB>N nanoparticles are uniformly distributed on the C<SUB>2</SUB>N substrate, becoming the Fe@C<SUB>2</SUB>N catalyst, which displayed ORR activities superior to commercial Pt/C in both acidic and alkaline media. Furthermore, the Fe@C<SUB>2</SUB>N catalyst remained rust-free during harsh electrochemical testing even after 650h, suggesting that its unusual durability originates from indirect-contact electrocatalysis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Iron (Fe) nanoparticle cores encapsulated in electrochemically transparent and stable shells (Fe@C<SUB>2</SUB>N) are prepared. </LI> <LI> The Fe@C<SUB>2</SUB>N catalyst displays superb oxygen reduction (ORR) performance in both alkaline and acidic media. </LI> <LI> The advantages of Fe@C<SUB>2</SUB>N catalyst over commercial Pt/C are low-cost and comparable ORR activity and superior durability. </LI> <LI> The unusual ORR performance is the result of the electrochemically stable and transparent encapsulating shells. </LI> <LI> Encapsulating shells allow not only an efficient electron tunneling but also protecting unstable active Fe cores. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Oxygen reduction catalyst from iron encapsulated in C<SUB>2</SUB>N framework (Fe@C<SUB>2</SUB>N) exhibits outstanding catalytic activities in both alkaline and acidic media. The Fe@C<SUB>2</SUB>N catalyst holds great potential for commercialization.</P> <P>[DISPLAY OMISSION]</P>

Bathyal records of enhanced silicate erosion and weathering on the exposed Luzon shelf during glacial lowstands and their significance for atmospheric CO₂ sink

Xu, Zhaokai,Li, Tiegang,Clift, Peter D.,Wan, Shiming,Qiu, Xiaohua,Lim, Dhongil Elsevier 2018 Chemical geology Vol.476 No.-

<P><B>Abstract</B></P> <P>We present a new high-resolution multiproxy data set of mass accumulation rates, Sr-Nd isotopes, as well as major and trace elements for the siliciclastic sediment fraction from International Marine Global Change Study Core MD06-3052, located on the continental slope of the western Philippine Sea. We integrate our new data with published grain sizes and sea surface temperatures from the same core, as well as with Equatorial Pacific sea level, and East Asian summer monsoon precipitation, in order to constrain at high-resolution changes in physical erosion and chemical weathering intensities on Luzon, and sediment source-to-sink processes. We assess the potential significance of chemical weathering of arc silicates in regulating global atmospheric CO<SUB>2</SUB> since 156kyr BP. Sr-Nd isotopes show that the siliciclastic sediments were dominantly sourced from volcanic rocks exposed on Luzon (~68–100%), with a lesser contribution from Asian dust (~0–32%). Different indices indicate that stronger physical erosion and chemical weathering occurred during Marine Isotope Stage (MIS) 6 (130–156kyr BP), as well as in the latter stage of MIS 3 and MIS 2 (14–40kyr BP). The large sea-level lowstands and associated significant exposure of continental shelf in the western Philippine Sea during these two cold periods should favor physical erosion and chemical weathering of unconsolidated sediments on the exposed shelf. Furthermore, we notice the relatively good coherence between chemical weathering intensities on Luzon and global atmospheric CO<SUB>2</SUB> concentrations over these cold intervals. We suggest that strengthening of chemical weathering of silicates on Luzon and other tropical arcs (within 20° of the Equator) during the Quaternary glacial sea-level lowstands may significantly contribute to the lowering of atmospheric CO<SUB>2</SUB> concentrations during ice ages. We estimate that a significant fraction, up to ~16% (i.e., ~8ppmv), of all atmospheric CO<SUB>2</SUB> ultimately sequestered by silicate weathering may be processed through an area corresponding to only ~1% of the exorheic drainage area worldwide.</P> <P><B>Highlights</B></P> <P> <UL> <LI> First high-resolution silicate weathering study of the western Philippine Sea. </LI> <LI> Glacial sea-level lowstands favored silicate weathering of sediments on exposed shelf. </LI> <LI> Enhanced weathering on tropical arcs significantly sequestered atmospheric CO2. </LI> </UL> </P>

Deubiquitination and Stabilization of PD-L1 by CSN5

Lim, Seung-Oe,Li, Chia-Wei,Xia, Weiya,Cha, Jong-Ho,Chan, Li-Chuan,Wu, Yun,Chang, Shih-Shin,Lin, Wan-Chi,Hsu, Jung-Mao,Hsu, Yi-Hsin,Kim, Taewan,Chang, Wei-Chao,Hsu, Jennifer L.,Yamaguchi, Hirohito,Ding Elsevier 2016 Cancer cell Vol.30 No.6

<P><B>Summary</B></P> <P>Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization of programmed cell death-ligand 1 (PD-L1). We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells. CSN5 inhibits the ubiquitination and degradation of PD-L1. Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TNF-α stabilizes cancer cell PD-L1 in response to chronic inflammation </LI> <LI> Activation of NF-κB by TNF-α induces CSN5 expression leading to PD-L1 stabilization </LI> <LI> CSN5 enzyme activity controls T cell suppression via PD-L1 deubiquitination </LI> <LI> Destabilization of PD-L1 by CSN5 inhibitor curcumin benefits anti-CTLA4 therapy </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>

Pollen record of the mid- to late-Holocene centennial climate change on the East coast of South Korea and its influential factors

Song, Bing,Yi, Sangheon,Jia, Hongjuan,Nahm, Wook-Hyun,Kim, Jin-Cheul,Lim, Jaesoo,Lee, Jin-Young,Sha, Longbin,Mao, Limi,Yang, Zhongyong,Nakanishi, Toshimichi,Hong, Wan,Li, Zhen Elsevier 2018 Journal of Asian earth sciences Vol.151 No.-

<P><B>Abstract</B></P> <P>To understand historical climate change in western Pacific coastal areas, a sediment core (SOJ-2) from the stable sedimentary environment of the Songjiho Lagoon on the east coast of South Korea was obtained for centennial-resolution palynological analysis. The ages of the SOJ-2 core is well controlled by carbon 14 dating with high-resolution accelerator mass spectrometry (AMS), and the results indicated a general warm to cold climate trend from the mid-Holocene to the present, which can be divided into two different stages: a warmer stage between 6842 and 1297 cal yr BP and a colder stage from 1297 cal yr BP to the present, with fluctuations during these stages. The climate was wetter from 6842 to 6227 cal yr BP and 4520 to 1297 cal yr BP and was drier from 6227 to 4520 cal yr BP. The climate changed to cold and dry during the period from 1297–425 cal yr BP. The impact of human activity on the climate began at approximately 1297 cal yr BP and became pronounced starting in 425 cal yr BP. The general cooling trend may represent a response to decreasing solar insolation; however, the relative dryness or wetness of the climate may have been co-determined by westerlies and the East Asian summer monsoon (EASM). The climate had a teleconnection with the North Atlantic region, resulting from changes in solar activity. Nevertheless, EI Niño–Southern Oscillation (ENSO) activity played an important role in impacting the EASM changes in western Pacific coastal areas.</P> <P><B>Highlights</B></P> <P> <UL> <LI> There is a centennial resolution climate record from 6842 cal yr BP to present. </LI> <LI> The general cooling trend was probably triggered by decreasing solar insolation. </LI> <LI> The precipitation was co-determined by westerlies and the East Asian Summer Monsoon. </LI> <LI> The ENSO activity may be an important factor for East Asian Summer Monsoon change. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Cooperation between Human DAF and CD59 in Protecting Cells from Human Complement-mediated Lysis

( Li Xu ),( Wen Lan Wu ),( Zhou Zhou Zhao ),( Huan Jie Shao ),( Wan Hong Liu ),( Hui Liu ),( Wen Xin Li ) 생화학분자생물학회 2006 BMB Reports Vol.39 No.6

Study on aerodynamic coefficients and responses of the integrated catwalk of Halogaland Bridge

Wan, Jia-wei,Wang, Qi,Liao, Hai-li,Li, Ming-shui Techno-Press 2017 Wind and Structures, An International Journal (WAS Vol.25 No.3

Wind tunnel tests and numerical aerodynamic analyses were conducted for an integrated catwalk structure under strong winds. From the wind tunnel tests, it is found that the aerodynamic coefficients were different from those of the typical type. The drag coefficient was larger than typical and was sensitive to number of vertical meshes installed rather than the solidity ratio. Comparing with typical catwalk, the integrated one showed larger deformation under strong wind, and the large torsional deformation are mainly caused by drag force. It did not show aerodynamic divergence even the torsional deformation reaching $20^{\circ}$. The reason could be that the stiffness is smaller and thus the catwalk is able to deform to the shape compactable with higher loading. Considering safety for construction, storm rope system is introduced to the catwalk to reduce the deformation to acceptable level.

Effect of Diallyl Trisulfide on Human Ovarian Cancer SKOV-3/DDP Cell Apoptosis

Wan, Hui-Fang,Yu, Le-Han,Wu, Jin-Lan,Tu, Shuo,Zhu, Wie-Feng,Zhang, Xia-Li,Wan, Fu-Sheng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Aim: To investigate the effects of diallyl trisulfide (DT) on apoptosis of cisplatin (DDP)-resistant human epithelial ovarian cancer SKOV-3 cells (SKOV-3/DDP), and the role of p53 upregulated modulator of apoptosis (PUMA). Methods: SKOV-3/DDP cells were randomly divided into control, DT, DPP and DPP+DT groups, which were treated with DT or combined DT and DDP. All cells were incubated for 48 h. and apoptosis rates were assessed by flow cytometry. mRNA and protein expression of PUMA, Bax and Bcl-2 was determined by RT-PCR and Western blot assays, respectively. Results: Compared with control group, the apoptosis rates of SKOV-3/DDP cells in DT groups were obviously increased, with dose-dependence (P < 0.05), the mRNA and protein expressions of PUMA, Bax also being up-regulated (P < 0.05), while those of Bcl-2 were down-regulated (P < 0.05). Compared with DT groups, the apoptosis rate in the DDP+DT group was significantly increased (P < 0.05). After knockdown of PUMA with specific siRNA, the apoptosis rate of SKOV-3/DDP cells was obviously decreased (P < 0.05). Conclusion: DT can promote the apoptosis of SKOV-3/DDP cells with PUMA playing a critical role.

Associations Between TLR9 Polymorphisms and Cancer Risk: Evidence from an Updated Meta-analysis of 25,685 Subjects

Wan, Guo-Xing,Cao, Yu-Wen,Li, Wen-Qin,Li, Yu-Cong,Zhang, Wen-Jie,Li, Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

A meta-analysis incorporating 34 case-control studies from 19 articles involving 12,197 cases and 13,488 controls was conducted to assess the effects of three genetic variants of Toll-like receptor 9 (TLR9): rs187084, rs352140, and rs5743836. Studies on associations between TLR9 polymorphisms and cancer risk were systematically searched in electronic databases. The reported odds ratios (OR) and 95% confidence intervals (CI) were pooled to assess the strength of any associations. The results showed that the rs187084 polymorphism was significantly associated with an increased risk of cancer (CC vs TC+TT: OR=1.14, 95% CI=1.02-1.28), specifically cervical cancer (C vs T: OR=1.19, 95% CI=1.05-1.34; TC vs TT: OR=1.32, 95% CI=1.10-1.58; CC vs TT: OR=1.31, 95% CI=1.03-1.68; CC+TC vs TT: OR=1.32, 95% CI=1.11-1.56), and that this association was significantly positive in Caucasians (CC vs. TC+TT: OR=1.18, 95% CI=1.01-1.38). The rs352140 polymorphism had a protective effect on breast cancer (GA vs GG: OR=0.77, 95% CI=0.66-0.89), whereas the rs5743836 polymorphism was likely protective for digestive system cancers (CC+TC vs TT: OR=0.81, 95% CI=0.66-0.98). In conclusion, our results suggest that the rs187084 polymorphism may be associated with an elevated cancer risk, whereas polymorphisms of rs352140 and rs5743836 may play protective roles in the development of breast and digestive system cancers, respectively. From the results of this meta-analysis further large-scale case-control studies are warranted to verify associations between TLR9 polymorphisms and cancer.

Abstract title: Using 2-phase Image Learning to Improve the Competency of First-aid Management for Nurses

Wan-Ching Huang,Tzu-Ping Liu,Wan-Chen Li,Chia-Lun Lee 한국간호과학회 2019 한국간호과학회 학술대회 Vol.2019 No.10

Product data model for PLM system

Li, Yumei,Wan, Li,Xiong, Tifan Society for Computational Design and Engineering 2011 International Journal of CAD/CAM Vol.11 No.1

Product lifecycle management (PLM) is a new business strategy for enterprise's product R&D. A PLM system holds and maintaining the integrity of the product data produced throughout its entire lifecycle. There is, therefore, a need to build a safe and effective product data model to support PLM system. The paper proposes a domain-based product data model for PLM. The domain modeling method is introduced, including the domain concept and its defining standard along the product evolution process. The product data model in every domain is explained, and the mapping rules among these models are discussed. Mapped successively among these models, product data can be successfully realized the dynamic evolution and the historical traceability in PLM system.