http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Wahedi, H.M.,Jeong, M.,Chae, J.K.,Do, S.G.,Yoon, H.,Kim, S.Y. Urban und Fischer Verlag 2017 Phytomedicine Vol.28 No.-
<P>Conclusion: Aloesin ameliorates each phase of the wound healing process including inflammation, proliferation and remodeling through MAPK/Rho and Smad signaling pathways. These findings indicate that aloesin has the therapeutic potential for treating cutaneous wounds. (C) 2017 Elsevier GmbH. All rights reserved.</P>
Novel aryl carbamate derivatives of metronidazole as potential antiamoebic agents
Hayat Faisal,HUSSAIN MUSTATAB WAHEDI,Seonghyeok Park,Saba Tariq,Amir Azam,신동윤 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.1
A series of novel aryl carbamate derivatives of metronidazole (MNZ) were designed, synthesized, and screened for antiamoebic activity. As compared to MNZ, most of the derivatives exhibited moderate to excellent activity against the HM1:IMSS strain of Entamoeba histolytica. Compounds 7, 14, 16, 19, and 21 exhibited the most promising antiamoebic activity with IC50 values of 0.24, 0.08, 0.26, 0.26, and 0.15 lM, respectively, compared to that of MNZ (1.78 lM). Moreover, from the toxicological studies of these compounds on human melanocytes, the melan-a cell line revealed that the potent compounds are nontoxic at concentrations ranging from 2.5 to 50 lM.
<i>Lespedeza bicolor</i> ameliorates endothelial dysfunction induced by methylglyoxal glucotoxicity
Do, Moon Ho,Lee, Jae Hyuk,Wahedi, Hussain Mustatab,Pak, Chaeho,Lee, Choong hwan,Yeo, Eui-Ju,Lim, Yunsook,Ha, Sang Keun,Choi, Inwook,Kim, Sun Yeou Elsevier 2017 Phytomedicine Vol.36 No.-
<P>Conclusion: LB1 extract has shown to be effective in preventing or treating MGO-induced endothelial dysfunction.</P>
Subedi, Lalita,Lee, Taek Hwan,Wahedi, Hussain Mustatab,Baek, So-Hyeon,Kim, Sun Yeou Hindawi 2017 Oxidative medicine and cellular longevity Vol.2017 No.-
<P>The skin is the outermost protective barrier between the internal and external environments in humans. Chronic exposure to ultraviolet (UV) radiation is a major cause of skin aging. UVB radiation penetrates the skin and induces ROS production that activates three major skin aging cascades: matrix metalloproteinase- (MMP-) 1-mediated aging; MAPK-AP-1/NF-<I>κ</I>B-TNF-<I>α</I>/IL-6, iNOS, and COX-2-mediated inflammation-induced aging; and p53-Bax-cleaved caspase-3-cytochrome C-mediated apoptosis-induced aging. These mechanisms are collectively responsible for the wrinkling and photoaging characteristic of UVB-induced skin aging. There is an urgent requirement for a treatment that not only controls these pathways to prevent skin aging but also avoids the adverse effects often encountered when applying bioactive compounds in concentrated doses. In this study, we investigated the efficacy of genetically modified normal edible rice (NR) that produces the antiaging compound resveratrol (R) as a treatment for skin aging. This resveratrol-enriched rice (RR) overcomes the drawbacks of R and enhances its antiaging potential by controlling the abovementioned three major pathways of skin aging. RR does not exhibit the toxicity of R alone and promisingly downregulates the pathways underlying UVB-ROS-induced skin aging. These findings advocate the use of RR as a nutraceutical for antiaging purposes.</P>