Poster Session : PS 0047 ; Cardiology : Associations Between Levels of Syntax Score and Hospital Complications in Patients with ST-Segment Elevation Myocardial Infarction

( Irina Urvantseva ),( Konstantin Nikolaev ),( Mikhail Voevoda ),( Alevtina Nikolaeva ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: SYNTAX score (SS) is an effective angiographic predictor of clinical outcomes in patients with multivessel coronary artery disease undergoing percutaneous coronary intervention, but the associations between high SS and short-term outcome in patients treated with primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI) have not been studied. The aim of this study was to evaluate associations of the severity of coronary artery disease according to SYNTAX score with short-term outcome and clinical characteristics in patients treated with PCI for acute STEMI. Methods: A total of 330 patients (274 male и 56 females, mean age 53.6±8.9 years) with acute STEMI who underwent primary PCI were stratifi ed into the 3 groups. For SS the following distribution was used: low (=22, N = 216), medium (23-32, N = 66), high score (>32, N = 48). All in-hospital clinical outcomes were estimated in these patients. Results: During the short-term observation in hospital cardiovascular mortality was higher in groups of high and medium SS in compared with group of low SS (18.8%, 12.1% and 1.4%, respectively, p<0.01). Besides that the no-refl ow phenomenon, stent thrombosis, pulmonary edema, pleural effusion, acute left ventricular aneurysm, recurrent myocardial infarction and bleeding were signifi cantly more frequent among the patients in high SS group (p<0.05). Multivariate binary logistic regression analyses demonstrated that SS is an independent determinant for pleural effusion (95 % confi dence interval (CI), 1.019-1.082; p=0.002), no-refl ow phenomenon (95 % CI, 1.008- 1.089; p=0.018), pulmonary edema (95 % CI, 1.027-1.090; p<0.001) and acute left ventricular aneurysm (95 % CI, 1.015-1.092; p=0.006). Conclusions: The SS is useful index to predict the risk of short-term adverse clinical events during hospitalization in patients with acute STEMI undergoing PCI.

Association of Polymorphism Harbored by Tumor Necrosis Factor Alpha Gene and Sex of Calf with Lactation Performance in Cattle

Yudin, N.S.,Aitnazarov, R.B.,Voevoda, M.I.,Gerlinskaya, L.A.,Moshkin, M.P. Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.10

In a majority of mammals, male infants have heavier body mass and grow faster than female infants. Accordingly, male offspring nursing requires a much greater maternal energy contribution to lactation. It is possible that the maternal-fetal immunoendocrine dialog plays an important role in female preparation for lactation during pregnancy. Immune system genes are an integral part of gene regulatory networks in lactation and tumor necrosis factor alpha ($TNF{\alpha}$) is a proinflammatory cytokine that also plays an important role in normal mammary gland development. The aim of this study was to evaluate the influence of the sex of calf and/or the -824A/G polymorphism in the promoter region of $TNF{\alpha}$ gene on milk performance traits in Black Pied cattle over the course of lactation. We also studied the allele frequency differences of -824A/G variants across several cattle breeds, which were bred in different climatic conditions. The G allele frequency decreased gradually over the course of lactation events in the Black Pied dairy cattle because of a higher culling rate of cows with the G/G genotype (p<0.001). In contrast to the genotypes A/A and A/G, cows with G/G genotype showed significant variability of milk and milk fat yield subject to sex of delivered calf. Milk yield and milk fat yield were significantly higher in the case of birth of a bull calf than with a heifer calf (p<0.03). The G allele frequency varies from 48% to 58% in Grey Ukrainian and Black Pied cattle to 77% in aboriginal Yakut cattle. Our results suggest that the $TNF{\alpha}$-824A/G gene polymorphism may have an influence on the reproductive efforts of cows over the course of lactation events depending on the sex of progeny. Allocation of resources according to sex of the calf allows optimizing the energy cost of lactation. This may be a probable reason for high G allele frequency in Yakut cattle breeding in extreme environmental conditions. Similarly, the dramatic fall in milk production after birth of a heifer calf increases the probability of culling for the cows with the G/G genotype in animal husbandry.

Poster Session:PS 0171 ; Diabetes : The Prevalence of Hypertension in Young Patients with Diabetes Mellitus

( Alla Ovsyannikova ),( Oksana Rymar ),( Vladimir Maximov ),( Mikhail Voevoda ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The aim of research was to determine the incidence of arterial hypertension in patients with debut of diabetes mellitus before 25 years of age. Methods: We examined 70 people in Siberia who had debut of diabetes mellitus up to 25 years: 5 patients had been confi rmed MODY 2, 33 patients had type 1 diabetes, 32 patients - type 2. We have done clinical examination, measurement of blood pressure, blood sampling for biochemical and hormone (TSH, C-peptide) analyzes. Arterial hypertension was diagnosed when blood pressure (BP) is above then 139/89 mm Hg for people older 18 years and above 95 percentile of the distribution BP for patients younger than 18 years. Results: The median of age of the patients at moment of examination was 23,0 [16,0:35,5] years for patients with type 1, with type 2- 29,5 [17,7:37,0] years (p1- 2<0,001), with MODY 2 -13,0 [6,5:30,5] years (p2-mody=0,022). The median of duration of diabetes mellitus was 9,0 [3,5:19,5] years at type 1: 2,0 [1,0:5,0] years at type 2: 3,0[1,0:4,0] years at MODY 2 (p1-2 = 0,02, p1- MODY = 0,04). 5 patients (15%) with type 1 diabetes had hypertension 1 and 2 degrees. 6 patients (19%) with type 2 diabetes also have high blood pressure. Patients with MODY 2 had not arterial hypertension. Overweight was present in 2 patients (6%) with type 1 diabetes and in 5 (16%) - with type 2 diabetes. Conclusions: 1. Young patients with diabetes have high incidence of hypertension which requires good monitoring pressure in these patients from the time of diagnosis of diabetes. 2. Overweight in young patients with diabetes is rarer than hypertension. It is indicate the need for controlling the pressure in the persons not only with the overweight but with normal weight too.

Slide Session : OS-END-08 ; Diabetes : Diabetes Mellitus in Young People: Clinical and Molecular Genetic Aspects

( Alla Ovsyannikova ),( Oksana Rymar ),( Vladimir Maximov ),( Mikhail Voevoda ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The aim was to investigate the clinical, laboratory and genetic determinants of diabetes mellitus in patients with debut of disease before 25 years of age and family history of diabetes in Siberia. Methods: We examined 70 people with debut of diabetes before 25 years of age with family history of diabetes: 5 patients who we verified MODY 2 (after molecular genetic testing), 33 diagnosed with type 1 diabetes at 32 - 2 type. All patients had a clinical examination, blood sampling for biochemical, hormone and molecular genetic (research glucokinase gene) analyzes. Results: Missense mutations in the glucokinase gene were localized in exons 1,4 and 7. The “classical” symptoms of debut were in 94% of patients with 1 type of diabetes. Asymptomatic debut of “diabetes no type 1” was in 60% of patients. Allergic reactions dominated among the comorbidities in patients with diabetes. Pathologies of the gastrointestinal tract (diabetes mellitus type 1 -27%, 2 type -12 %, MODY 2-20%), thyroid (18 %, 28 % and 40 % respectively), hypertension (18 % with type 1, 28 % - type 2) were in these patients. Peripheral diabetic neuropathy and diabetic retinopathy prevailed among the complications. Statistical differences were found in glucose, glycated hemoglobin, C-peptide, C-reactive protein among laboratory parameters in patients with diabetes mellitus type 1 and type 2. Conclusions: 1. We discovered a new one missense mutation and three previously described mutations in the glucokinase gene. 2. Young patients with type 1 diabetes had “classic” symptoms. Patients with “diabetes not type 1” had not clinical symptoms (60%) and had normal body weight (84 %). 3. Allergic reactions and diseases of the thyroid gland dominated in all types of diabetes mellitus in patients of the young age.