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Basivi, Praveen Kumar,Pasupuleti, Visweswara Rao,Seella, Ramanaiah,Tukiakula, Madhusudana Reddy,Kalluru, Subramanyam Reddy,Park, Soo-Jin American Chemical Society 2017 Journal of chemical and engineering data Vol.62 No.7
<P>The inverse gas chromatography study on the fluconazole drug surface was performed, and the net retention volumes, polar probes, and VN of n-alkanes are determined at four temperatures over the range 318.15-333.15 K. The net retention values of n-alkanes were used to evaluate the London dispersive surface free energy gamma(L)(S) by three different methods, namely, the Donnet Park, Dorris Gray, and Schultz methods. The gamma(L)(S) values were found to increase from 318.15 to 323.15 K for all three methods and then decrease from 323.15 to 333.15 K. The gamma(L)(S) values were found to be slightly higher in the Schultz method when compared to the results of the Donnet-Park and Dorris-Gray methods. The specific free energy values Delta G(a)(s) and the specific enthalpy Delta H-a(s) values have been calculated using the V-N data of polar probes. The Guttmann Lewis acid base parameters, K-a and K-b, were obtained using Delta H-a(s) values and were found to be 0.217 and 1.518, respectively. The surface character (K-b/K-a) was found to be 7.0. The results revealed that the fluconazole powder surface contains relatively more basic sites than acidic sites and can combine strongly with acidic substrates. The surface energy and acid base data of fluconazole can be used during formulation of the drug and to understand the drug release process.</P>
Microwave Assisted One-pot Synthesis of Novel α-Aminophosphonates and Their Biological Activity
Alahari Janardhan Rao,Pasupuleti Visweswara Rao,Valsani Koteswara Rao,Challamchalla Mohan,Chamarthi Naga Raju,Cirandur Suresh Reddy 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.7
A simple and efficient synthesis of various α-aminophosphonates (3a-l) by the reaction of substituted aromatic/heterocyclic aldehydes, 2-amino-6-methoxy-benzothiazole and dibutyl/diphenyl phosphites under microwave irradiation without catalyst was accomplished. The phosphonates were characterized by elemental analysis, IR, 1H, 13C- and 31PNMR spectra. They showed promising antimicrobial, anti-oxidant activities depending on the nature of bioactive groups at the α-carbon.
Microwave Assisted One-pot Synthesis of Novel α-Aminophosphonates and heir Biological Activity
Rao, Alahari Janardhan,Rao, Pasupuleti Visweswara,Rao, Valsani Koteswara,Mohan, Challamchalla,Raju, Chamarthi Naga,Reddy, Cirandur Suresh Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.7
A simple and efficient synthesis of various $\alpha$-aminophosphonates (3a-l) by the reaction of substituted aromatic/heterocyclic aldehydes, 2-amino-6-methoxy-benzothiazole and dibutyl/diphenyl phosphites under microwave irradiation without catalyst was accomplished. The phosphonates were characterized by elemental analysis, IR, $^1H$, $^{13}C$- and $^{31}PNMR$ spectra. They showed promising antimicrobial, anti-oxidant activities depending on the nature of bioactive groups at the $\alpha$-carbon.
Functional PstI/RsaI Polymorphisms in the CYP2E1 Gene among South Indian Populations
Lakkakula, Saikrishna,Maram, Rajasekhar,Munirajan, Arasambattu Kannan,Pathapati, Ram Mohan,Visweswara, Subrahmanyam Bhattaram,Lakkakula, Bhaskar V.K.S. Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Human cytochrome P4502E1 (CYP2E1) is a well-conserved xenobiotic-metabolizing enzyme expressed in liver, kidney, nasal mucosa, brain, lung, and other tissues. CYP2E1 is inducible by ethanol, acetone, and other low-molecular weight substrates and may mediate development of chemically-mediated cancers. CYP2E1 polymorphisms alter the transcriptional activity of the gene. This study was conducted in order to investigate the allele frequency variation in different populations of Andhra Pradesh. Two hundred and twelve subjects belonging to six populations were studied. Genotype and allele frequency were assessed through TaqMan allelic discrimination (rs6413419) and polymerase chain reaction-sequencing (-1295G>C and -1055C>T) after DNA isolation from peripheral leukocytes. The data were compared with other available world populations. The SNP rs6413419 is monomorphic in the present study, -1295G>C and -1055C>T are less polymorphic and followed Hardy-Weinberg equilibrium in all the populations studied. The -1295G>C and -1055C>T frequencies were similar and acted as surrogates in all the populations. Analysis of HapMap populations data revealed no significant LD between these markers in all the populations. Low frequency of $CYP2E1^*c2$ could be useful in the understanding of south Indian population gene composition, alcohol metabolism, and alcoholic liver disease development. However, screening of additional populations and further association studies are necessary. The heterogeneity of Indian population as evidenced by the different distribution of $CYP2E1^*c2$ may help in understanding the population genetic and evolutionary aspects of this gene.