http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Whey Versus Soy Protein Diets and Renal Status in Rats
Virginia A. Aparicio,Elena Nebot,Mohamed Tassi,Daniel Camiletti-Moiron,Cristina Sanchez-Gonzalez,Jesus M. Porres,Pilar Aranda 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.9
Different dietary protein sources can promote different renal statuses. We examined the effects of whey protein (WP) and soy protein (SP) intake on plasma, urinary, and morphological renal parameters in rats. One hundred and twenty Wistar rats were randomly distributed into 2 experimental groups fed with either WP or SP diets over 12 weeks. These diets were based on commercial WP or SP isolates. The urinary calcium content was higher in the WP diet compared to the SP diet group (P < .001) whereas the urinary citrate level was lower (P < .001). The urinary pH was more acidic in the WP diet group compared to the SP diet group (P < .001); however, no differences were observed between the groups for any of the renal morphological parameters analyzed (all, P > .05) or other plasma renal markers such as albumin or urea concentrations. The increase of acid and urinary calcium and the lower urinary citrate level observed in the WP diet group could increase the incidence of nephrolithiasis compared to the SP diet group. Despite the WP showed poorer acid-base profile, no significant morphological renal changes were observed. These results suggest that the use of SP instead of WP appears to promote a more alkaline plasma and urinary profile, with their consequent renal advantages.
Extensive variability in the composition of immune infiltrate in different mouse models of cancer
Virginia Niemi,Douglas Gaskarth,Roslyn A. Kemp 한국실험동물학회 2020 Laboratory Animal Research Vol.36 No.4
Mouse models are invaluable tools for cancer immunology research. However, there are differences in the immune response to the tumour depending on the model used, and these differences are not often characterised on their own. Instead they are often only analysed in response to a therapeutic immune modulation. There are important issues with translatability into effective clinical research when considering the choice of mouse models. Here we analysed the tumour immune microenvironment and modified aspects of the tumour model to determine the effect on the composition of the immune infiltrate. Mice injected subcutaneously with the melanoma cell line, B16-OVA, had a higher frequency of T cells, especially CD8+ T cells, than mice injected subcutaneously with CT26 colorectal adenocarcinoma cells. We compared the same tumour cell line (CT26) delivered either subcutaneously and intracaecally. To minimise immunological impacts due to the invasive surgery procedure, we optimised an existing intracaecal injection protocol. Intracaecal tumours had a higher frequency of infiltrating CD3+ CD4+ T cells and a lower frequency of CD3-CD19- (putative NK cells) than subcutaneous tumours. In contrast, there was a higher frequency of F480+ macrophages in subcutaneous tumours than intracaecal tumours. These data demonstrate that variability between animals, between experiments and within tumour models, can lead to difficulty in interpreting the infiltrating immune response and translating this response to clinical research.
케나프 속대의 산 가수분해 처리를 통한 고순도 셀룰로오스 생산
Virginia Ghita Firsty,임서경,구양모,이진형,신수정 한국펄프·종이공학회 2023 펄프.종이기술 Vol.55 No.1
For sustainable industries based renewable biomass, secure of raw material is important. Kenaf is a good candidate with fast-growing and high biomass productvity. Acid hydrolysis treatment of kenaf woody core is capable produced high purity cellulose for fine chemical production, which was hydrolyzed hemicelluloses (mainly xylan) to monosaccharides. The effects of various reaction temperatures (110-130℃), and reaction times (60-120 min) were investigated to get the optimum condition. 1 H NMR spectroscopy was used to quantitative analysis of polysaccharide composition based on hydrolzed monosaccharides analysis. The results showed that optimum conditions for acid hydrolysis treatment was 1.00N sulfuric acid, 130℃, and 60 min for higher purity cellulose production with cellulose as 50.0%, hemicellulsoe as 1.2%) and lignin as 0.3% based on raw kenaf core biomass. .
Virginia Liberini 대한핵의학회 2024 핵의학 분자영상 Vol.58 No.1
A 79-year-old man with prostate cancer (PCa) was referred to our center to perform a [11C]Choline PET/CT for biochemicalrecurrence. Positron emission tomography/computed tomography (PET/CT) scan detected PCa recurrence in the prostategland and several pelvic and abdominal lymph nodes. Two abnormal uptakes were also identified in the right breast and inthe liver, respectively. Breast histological findings turned out to be gynecomastia, while the liver lesion resulted in a benignperfusion anomaly at follow-up magnetic resonance imaging (MRI). Although incidental findings were benign in this case,it is important to always investigate abnormal uptakes of [11C]Choline, as it could be an expression of further metastases orsynchronous malignancies such as breast cancer and hepatocellular carcinoma.
Virginia Sarropoulou,Kortessa Dimassi-Theriou,Ioannis Therios 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.4
The effects of indole-3-butyric acid (IBA) alone and in combination with L-arginine on the morphogenic and biochemical responses in shoot tip explants of the cherry rootstock M 9 M 14 (Prunus avium 9 Prunus mahaleb) were examined. The maximum root number per rooted explant (16), root fresh (FW) and dry (DW) weights, as well as the rooting percentage (100 %) were recorded when 2 mg l-1 IBA (alone) were applied. Including the lowest IBA concentration (0.5 mg l-1) with the lowest and highest L-arginine concentrations (0.5 and 2 mg l-1, respectively) resulted in the greatest root length. The maximum leaf chlorophyll concentration and shoot length of the initial explant were recorded when 0.5 mg l-1 IBA plus 2 mg l-1 L-arginine were applied. In addition,L-arginine in combination with IBA (1 and 2 mg l -1) was found to suppress shoot FW and DW. On the other hand, L-arginine enhanced the promoting effect of IBA on both root length and leaf chlorophyll concentration. The carbohydrate and proline concentrations in leaves were not significantly altered with the application of IBA alone or incombination with L-arginine. On the other hand, the carbohydrate and proline concentrations in roots were decreased with the application of 1 and 2 mg l-1 IBA with L-arginine, resulting in the suppression of the promoting effects of IBA. It is clear from the findings that L-arginine has a direct effect on the in vitro rooting of M 9 M 14 explants, is involved in the function of the photosythetic apparatus, influences leaf chlorophyll content, participates in carbohydrate biosynthesis and metabolism, and is involved in proline accumulation both in leaves and roots.
Permeability factors in nephrotic syndrome and focal segmental glomerulosclerosis
( Virginia J. Savin ),( Ellen T. Mccarthy ),( Mukut Sharma ) 대한신장학회 2012 Kidney Research and Clinical Practice Vol.31 No.4
Circulating permeability factors have been identified in the plasma of patients with focal segmental glomerulosclerosis (FSGS). Post-transplant recurrence of protei-nuria, improvement of proteinuria after treatment with plasmapheresis, and induction of proteinuria in experimental animals by plasma fractions each provide evidence for such plasma factors. Advanced proteomic methods have identified candidate molecules in recurrent FSGS. We have proposed cardiotrophin-like cytokine-1 as an active factor in FSGS. Another potential permeability factor in FSGS is soluble urokinase receptor. In our studies, in vitro plasma permeability activity is blocked by substances that may decrease active molecules or block their effects. We have shown that the simple sugar galactose blocks the effect of FSGS serum in vitro and decreases permeability activity when administered to patients. Since the identities of permeability factors and their mechanisms of action are not well defined, treatment of FSGS is empiric. Corticosteroids are the most common agents for initial treatment. Calcineurin inhibitors, such as cyclosporine A, and tacrolimus and immunosuppressive medications, including mycophenylate, induce remission is some patients with steroid-resistant or -dependent nephrotic syndrome. Therapies that diminish proteinuria and slow progression in FSGS as well as other conditions include renin-angiotensin blockade, blood pressure lowering and plasma lipid control. Use of findings from in vitro studies, coupled with definitive identification of pathogenic molecules, may lead to new treatments to arrest FSGS progression and prevent recurrence after transplantation.