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Oral film technology: a perspective on translational research and clinical studies
Jeseeta Suresh,Nirmal Aravindaraj,Venkateshwaran Krishnaswami,Ruckmani Kandasamy 한국고분자학회 2023 Macromolecular Research Vol.31 No.10
In recent days, the prerequisite for effective and innovative drug delivery has increased and so the oral film technology (OFT) arena is being explored extensively. Oral films rapidly dissolve and are adsorbed in the buccal cavity; thereby, the incorporated therapeutic agent(s) in them are delivered into the systemic circulation and overcome the first-pass effect. It also uplifts the efficacy and bioavailability of therapeutics with minimal or no toxicity. Owing to its simpler mode of administration, patient compliance is increased even in non-cooperative and bedridden patients in comparison to conventional solid and liquid dosage forms. The present review provides an overview of the benefits and shortcomings of oral film technologies, anatomy, physiology of the oral cavity, and the transport and mucoadhesion mechanisms of the drug through the oral mucosa. This review also highlights the different components supporting drug delivery by oral films, the various production methods of oral films, and clinical trials along with commercial films available in the market.
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Balagurunathan, Muruganantham,Natarajan, Thrilok,Karthikeyan, Jothilakshmi,Palanisamy, Venkateshwaran The Korean Pediatric Society 2021 Clinical and Experimental Pediatrics (CEP) Vol.64 No.10
Background: Multisystem inflammatory syndrome in children (MIS-C) is a new hyperinflammatory variant that evolved during the coronavirus disease 2019 pandemic. Although the precise pathophysiology of MIS-C is uncertain, it is thought to be due to immune dysregulation occurring after recovery from acute infection. Purpose: Our study aimed to analyze the clinical spectrum, laboratory parameters, imaging characteristics, treatment strategies, and short-term outcomes of children with a diagnosis of MIS-C. Methods: This retrospective and prospective observational study included children less than 16 years of age who were admitted to the pediatric unit of a tertiary care teaching hospital in south India between August 2020 to January 2021 with a diagnosis of MIS-C according to World Health Organization criteria. Results: Twenty-one children were included in the analysis; all had fever with variable combinations of other symptoms. The mean age was 6.9 years; 71.4% were male. Gastrointestinal (80.9%) and cardiovascular (80.9%) systems were the most commonly affected. The majority of children had elevated inflammatory markers, and 16 (76.2%) had echocardiographic abnormalities mimicking Kawasaki disease. Eleven children (52.4%) required intensive care admission, 3 (14.3%) required supplemental oxygen, and 4 (19%) required inotropes. Nine (42.9%) were treated with intravenous immunoglobulin alone, 6 (28.6%) with steroids alone, and 3 (14.3%) with steroids and immunoglobulin. The median hospital stay was 6 days; there were no fatalities. Overweight/obesity, elevated ferritin, and mucocutaneous involvement were significantly associated with a prolonged hospital stay (≥7 days). Sixteen children (76.2%) were followed up till now and all of them had no clinical concerns. Conclusion: MIS-C is an emerging disease with variable presentation. A high index of suspicion is necessary for its early identification and appropriate management. Further research is essential for developing optimal treatment strategies.
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Ni-P Coated Glass Fiber/Al₂O₃ Nanowire Reinforced Vinyl Ester Composite
G. Anand,N. Alagumurthi,R. Elansezhian,N. Venkateshwaran 한국고분자학회 2017 폴리머 Vol.41 No.3
This study mainly focuses on the evaluation of mechanical and thermal properties of vinyl ester composite incorporated with E-glass fiber and aluminium oxide nanowires. These glass fibers are coated with Nickel Phosphorus (Ni-P) via electroless plating method after many trials. The Ni-P coated glass fiber (GF) increases the mechanical properties of the composite when used as the reinforcement. The maximum level of 53% increase in the tensile strength occurs at 0.75 wt% concentration of aluminium oxide nanowires and 40% of Ni-P coated GF as reinforcement. The similar outcome occurs for the other mechanical and wear properties. The thermal analysis reveals that the thermal stability of the composite increases with the increase in the concentration of Al₂O₃ nanowires as fillers and Ni-P/GF as reinforcement. Scanning electron microscope and optical microscope images are used to analyze the surface morphology of Ni-P coated GF, fractured and worn out surfaces of the samples.
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Substrate bias effects during diamond like carbon film deposition by microwave ECR plasma CVD
R.M. Dey,S.B. Singh,A. Biswas,R.B. Tokas,N. Chand,S. Venkateshwaran,D. Bhattacharya,N.K. Sahoo,S.W. Gosavi,S.K. Kulkarni,D.S. Patil 한국물리학회 2008 Current Applied Physics Vol.8 No.1
Diamond like carbon (DLC) coatings were deposited on silicon(11) substrates by microwave electron cyclotron resonance (ECR)plasma CVD process using a plasma of Ar and CH4 gases under the inuence of DC self bias generated on the substrates by applicationof RF (13.56 MHz) power. DLC coatings were deposited under the varying inuence of DC bias (. 60 V to. 150 V) on the Si substrates.atomic force microscopy (AFM), Hardness and elastic modulus determination technique, Raman spectroscopy, scanning electronmicroscopy (SEM) and contact angle measurement. The results indicate that the lm grown at. 100 V bias has optimised propertieslike high sp3/sp2 ratio of carbon bonding, high refractive index (2.262.17) over wide spectral range 4001200 nm, low roughness of0.8 nm, high contact angle (80.) compared to the lms deposited at other bias voltages (. 60 V and . with each other and nd august explanation under the subplantation model for DLC growth.
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