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VJ Galani,SS Goswami,MB Shah 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.3
Trichosanthes cucumerina Linn. (cucurbitaceae) is widely used in Indian folk medicine for variety of disease conditions. The aim of present study was to evaluate the antiulcer activity of 50%ethanolic extract of fruits of Trichosanthes cucumerina Linn. (TCFE) using various experimental models of gastric and duodenal ulceration in rats. Oral administration of 50% ethanolic extract of fruits of Trichosanthes cucumerina Linn. was evaluated in rats against ethanol, aspirin and pylorus ligated gastric ulcers as well as cysteamine-induced duodenal ulcers. In all the models studied,the antiulcer activity of TCFE compared with that of cimetidine (100 mg/kg, p.o.), an H2receptor antagonist. TCFE showed significant antiulcer activity in ethanol-induced and aspirin-induced gastric ulcer models. In 19 h pylorus ligated rats, significant reduction in ulcer index, total acidity and pepsin activity was observed with TCFE, when compared with the control group. Mucosal defensive factors such as pH, mucin activity and gastric wall mucous content was found to be increased with TCFE. TCFE was also, afforded remarkable protection in cysteamine-induced duodenal lesions. The antiulcer activity of TCFE was comparable with that of cimetidine. Thus,TCFE possess significant antiulcer activity against both gastric and duodenal ulcers in rats. The antiulcer activity may be attributed to its cytoprotective action and inhibition of acid secretary parameters.
Galani, VJ,Goswami, SS,Shah, MB Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.3
Trichosanthes cucumerina Linn. (cucurbitaceae) is widely used in Indian folk medicine for variety of disease conditions. The aim of present study was to evaluate the antiulcer activity of 50% ethanolic extract of fruits of Trichosanthes cucumerina Linn. (TCFE) using various experimental models of gastric and duodenal ulceration in rats. Oral administration of 50% ethanolic extract of fruits of Trichosanthes cucumerina Linn. was evaluated in rats against ethanol, aspirin and pylorus ligated gastric ulcers as well as cysteamine-induced duodenal ulcers. In all the models studied, the antiulcer activity of TCFE compared with that of cimetidine (100 mg/kg, p.o.), an $H_2$ receptor antagonist. TCFE showed significant antiulcer activity in ethanol-induced and aspirin-induced gastric ulcer models. In 19 h pylorus ligated rats, significant reduction in ulcer index, total acidity and pepsin activity was observed with TCFE, when compared with the control group. Mucosal defensive factors such as pH, mucin activity and gastric wall mucous content was found to be increased with TCFE. TCFE was also, afforded remarkable protection in cysteamine-induced duodenal lesions. The antiulcer activity of TCFE was comparable with that of cimetidine. Thus, TCFE possess significant antiulcer activity against both gastric and duodenal ulcers in rats. The antiulcer activity may be attributed to its cytoprotective action and inhibition of acid secretary parameters.
D Barreta,M Nardino,VA Konflanz,AJ de Pelegrin,M Ferrari,VJ Szareski,IR Carvalho,VQ de Souza,AC de Oliveira,LC da Maia 한국작물학회 2019 Journal of crop science and biotechnology Vol.22 No.2
In maize breeding, diallel crosses are commonly used to identify superior combinations. This methodology aims to estimate the genotypes combining ability. The objective of this study was to quantify the general and specific combining ability effects, as well as the reciprocal effect of 10 elite endogamic lines of maize. A total of 90 experimental hybrid combinations were obtained from diallel crosses, which were evaluated in three growing environments: Pato Branco-PR, Campos Novos-SC, and Frederico Westphalen-RS in the 2012/2013 growing season. The GCA indicates that the parents 7 and 10 are promising for the reduction of plant height, length, and number of tassel ramifications. The parent 5 promotes reduction of plant height and number of tassel ramifications. The parent 6 presents favorable estimates for reducing the length and number of tassel ramifications. The parents that are better combined with others according to GCA for grain yield are 2, 5, 6, and 7. The SCA indicates that hybridization between the parents 2x7, 5x9, 7x8, 2x9, 4x5, 1x5, 5x8, and 2x8 increases grain yield in the environments of study. Hybrids from the cross 5x10 were promising because they presented negative SCA values for plant height reduction. The hybrid combination 1x10 presents an estimate for tassel length reduction. The hybrids 5x10 and 4x6 are the most promising for reducing the number of tassel ramifications.