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Ryan Urban,Justin Wong,Peter Lim,Susan Zhang,Ingrid Spadinger,Robert Olson,Francois Bachand,Clement Ho,Anna V. Tinker,Lovedeep Gondara,Sarah Nicole Hamilton 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.5
Objective: To evaluate gastrointestinal (GI) patient reported outcomes (PROs) in cervical cancer patients treated with definitive radiotherapy (RT), comparing 3D conformal RT (3DCRT) vs. intensity modulated/volumetric modulated arc therapy (IMRT/VMAT). Methods: An analysis of patients treated with definitive RT between 2015–2018 was performed. GI PROs were prospectively collected at baseline, during RT (acute), ≤12 weeks after RT (subacute), and >12 weeks after RT (late). GI PROs evaluated three symptom domains: bowel problems (BPs), bowel bother (BB), and abdominal problems (APs). Multiple linear regression analysis was performed to investigate associations between mean changes of symptom scores with clinical and dosimetric variables. Results: The cohort included 167 patients. A total of 100 (60%) patients were treated with IMRT/VMAT and 67 (40%) with 3DCRT. In the subacute phase, the mean change of symptom scores from baseline in 3DCRT vs. IMRT/VMAT were +0.9 vs. −1.15 (p=0.004) for BP, +2.18 vs. −0.10 (p=0.019) for BB, and +1.41 vs. −0.38 (p=0.021) for AP. Likewise, in the late phase, mean changes were +0.72 vs. −0.82 (p=0.014) for BP, +1.98 vs. −0.03 (p=0.008) for BB, and +1.29 vs. −0.31 (p<0.001) for AP. On multiple linear regression, use of 3DCRT vs. IMRT/VMAT was associated with greater mean changes in subacute BP (p=0.023) and late phase AP (p=0.019). A higher small bowel V50Gy was associated increased symptom scores in late AP (p=0.012). Conclusion: 3DCRT was associated with significantly greater worsening of GI PRO symptom scores in the subacute and late phase. These data support the ongoing use of IMRT/VMAT in routine practice
LAGRANGE MULTIPLIER METHOD FOR SOLVING VARIATIONAL INEQUALITY IN MECHANICS
Robert V. Namm,우경수 대한수학회 2015 대한수학회지 Vol.52 No.6
Lagrange multiplier method for solving the contact problem in elasticity is considered. Based on lower semicontinuity of sensitivity functional we prove the convergence of modified dual scheme to corre- sponding saddle point.
Robert V. Namm,Gyungsoo Woo,Shu-Sen Xie,이수철 대한수학회 2012 대한수학회지 Vol.49 No.4
In this paper, the iterative Uzawa method with a modified Lagrangian functional is investigated to seek a saddle point for the semicoercive variational Signorini inequality.
Modified duality scheme for solving model crack problem in mechanics
Robert V. Namm,우경수 대한수학회 2017 대한수학회보 Vol.54 No.2
Duality methods based on modified Lagrangian functional for solving a model crack problem is considered. Without additional assumptions of regularity of the solution of an initial problem duality ratio is established for initial and dual problem.
Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues
( Roman V Shchepin ),( Wei Liu ),( Huiyong Yin ),( Irene Zagol Ikapitte ),( Taneem Amin ),( Byeong Seon Jeong ),( Jackson Roberts ),( John A Oates ),( Ned A Porter ),( Olivier Boutaud ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
Acetaminophen (ApAP) is an electron donor capable of reducing radicals generated by redox cycling of hemeproteins. It acts on the prostaglandin H synthases (cyclooxygenases; COXs) to reduce the protoporphyrin radical cation in the peroxidase site of the enzyme, thus preventing the intra-molecular electron transfer that generates the Tyr385 radical required for abstraction of a hydrogen from arachidonic acid to initiate prostaglandin synthesis. Unrelated to this pharmacological action, metabolism of ApAP by CYPs yields an iminoquinone electrophile that is responsible for the hepatotoxicity, which results from high doses of the drug. We synthesized novel heterocyclic phenols predicted to be electron donors. Two of these inhibited the oxygenation of arachidonic acid by PGHS-1 and myoglobin and also were shown to be more metabolically stable and exhibited less direct cytotoxicity than acetaminophen. They are leading candidates for studies to determine whether they are free of the metabolism-based hepatotoxicity produced by acetaminophen.