ẢNH HƯỞNG CỦA VĂN HOÁ TRONG VIỆC TIẾP NHẬN PHIM TRUYỀN HÌNH NƯỚC NGOÀI CỦA KHÁN GIẢ VIỆT NAM

ThS. Quách Thuyên Nhã Uyên 한국베트남학회 2022 한국베트남학회 학술대회 Vol.2022 No.06

Acetylcholine에 의한 적출 십이지장 평활근 수축에 미치는 Calcium 길항제의 영향

손의동,이만기,박창호,김인겸,김중영 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.2

To compare antagonistic action of caloium antagonists on intestinal smooth muscle contraction, acetylcholine-induced phasic contraction (PC) and tonic contraction (TC) initiated by different calcium utilization were observed in the presence of various calcium antagonists by the use of isolated mouse duodenum suspended in Tyrode's solution. By verapamil at 2.2×10 exp(-6), 2.2×10 exp(-5) and 2.2×10 exp(-4) mM, PC was more decreased dose-dependently than TC. By nifedipine at 7.9×10 exp(-5) mM, PC was more decreased than TC, but at 7.9×10 exp(-6) mM it did not affect PC and TC. By diltiazem at 6.1×10 exp(-4) mM, PC was more decreased than TC, but at 2.4×10 exp(-4) and 2.4×10 exp(-5) mM it did not affect both of the contractions. By cobalt chloride at 0.3, 1.3, and 2.6 mM, TC was significantly decreased without affecting PC, but PC markedly decreased at 5.2 mM. These results reconfirmed the fact that cobalt ion-induced calcium antagonism is more related to calcium influx process than calcium release process in contrast with the actions of verapamil, diltiazem, and nifedipine in duodenal smooth muscle.

중국의《 한어식조선말 》에 대한 고찰

장의원 국제비교한국학회 1995 비교한국학 Comparative Korean Studies Vol.1 No.-

This essay is the study on affected relation between Korean and Chinese in Chinese regions.

소아과 환자의 처방분석 및 검토

이종미,손의동 중앙대학교 약학연구소 2002 약학 논총 Vol.16 No.-

It is known that drug therapy of children is different from that of adults and the prescription is needed to the cautious, because drug's safety and dosage are not established. When the capsule is changed to powder form in pediatric patients, the effect and safety of treatment maybe lost. So I investigated the drug interactions and the alternation of dosage forms in dispensing of oral drug products for pediatric patients based on the prescriptions of Hospital A. One prescription is composed of 5.3 drugs, is prescribed an average 4.9 days and the pediatrics in hospital A used kinds of 145 drugs during January, 2002. Mucolytics are most common in prescriptions(49.6%), digestives, antibiotics, antihistamines and antipyreptics in senior. The most common disease is asthma in pediatric patients, sinusitis, rhinitis, bronchitis and pharyngitis in order. Among 11,534 prescriptions for 2,163 patients' drug interaction were found 133 cases, and most drugs belong to macrolides and asthma related drugs but not seriously. Among 21,678 prescriptions, the cases of alternation of dosage forms (tablets and capsules intended for constitution as powders) were 17,950 (83%), this result is showed that adult typed drugs are popular in pediatric department. The most common changing drug is fenoterol and the other drugs are theophylline, bromhexine, ketotifen fumarate, in order. Number of powder formed drug with decreased effectivenes, unplesant swelling and bitter tastes when powder formed are 726 cases. On the basis of the results of this study, several problems caused by the alternation were discussed, such as changes in bioavailability loss in dose, stability and the problem of feeding. It was suggested that the information in alternation must be given by the pharmaceutical manufacturer and the hospital pharmacists must consider these problems in pediatric dispensing. Above all, it was desirable to develop pediatric dosage forms by the pharmaceutical manufacturer.

소아과의원의 감기환자 처방 분석

한인희,손의동 중앙대학교 약학연구소 2002 약학 논총 Vol.16 No.-

It has been shown that the common cold is the most prevalent disease in humans generally caused by rhinovirus etc. It may be interesting if we compare pediatric's prescriptions drugs in local clinic, and find some differences to them. This research shows that antibiotic or/and antiviral drug use(s) between two pediatric's prescriptions are quite different. There are no licensed effective antiviral drugs for the common cold. Although bacterial involvement was rare and an uncomplicated common cold did not require combination treatment with antibiotics, antiviral and antibiotic therapy prescriptions increase insurance drug prices 2.59 times. When prescribed over 2 items in same efficacy drug group to patients, it will be one of the most reason of insurance fee increment. The therapeutic periods of them was not different when we compared to symptomatic and antibiotic therapy. This analysis to the pediatric's prescriptions drugs in local clinic provide the reference data for the basic guideline of standard prescriptions. Aspirin prescriptions as antipyretics-analgesics should be reinvestigated.

천마의 항 불안 효과

김여환,최형철,손의동,이광윤,김원준,박형배,하정희 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.2

천마(Gastrodia elata Blume)의 근경을 말린 것은 한방에서 오래전부터 여러 형태의 간질발작 치료 목적으로 이용되어지고 있었으나 어떤 활성물질에 의해 또 어떤 작용 기전을 통해 약리작용을 나타내는지를 충분하게 설명하지 못하고 있다. 최근 항경련 작용기전 연구 결과 천마추출물의 GABA성 신경전달계에 대한 조절작용과 관련이 있을 것이라는 연구 결과가 보고되었으며, 소량으로도 뇌억제 및 진정작용이 있다는 문헌을 참고하여 볼 때 천마의 항불안 작용 가능성이 시사되었다. 이에 본 연구를 통하여 천마를 사용하여 실험동물에서 항불안 작용을 검색하고 그 작용기전의 일부를 밝히고자 항불안작용 기전에 중요한 benzodiazepine 수용체와의 상호작용을 관찰하였다. 실험 결과, 천마 추출물의 경구 장기투여는 생쥐의 elevated plus maze 검사에서 개방 통로에로의 진입 및 개방통로에서의 체류시간을 증가시킴으로써 항불안 효과를 나타내었다. 천마의 에탄올 추출물은 benzodiazepine수용체 길항제인 [³H] Ro15-1788결합을 억제하였으며, 천마 추출물은 [³H] Ro15-1788의 수용체 결합에 대한 최대 결합력(Bmax)은 변화시키지 않고, 친화력(affinity)을 감소시킴으로써 상경적인 결합 양상을 나타내었다. 또 천마의 에탄올 추출물은 benzodiazepine 수용체의 효현제인 flunitrazepam의 수용체 결합반응을 억제시켰는데, 이러한 억제는 GABA 존재하에서 항진되는 것을 관찰하였다. 이상의 결과로 미루어보아 천마의 에탄올추출물 내에는 항불안작용을 나타내는 성분이 함유되어 있을 가능성을 예상케한다. Gastrodia elata Blume is a medicinal plant which has been used as anticonvulsant in oriental medicine, and has been used as sedatives. A survey of the relevant literature has indicated that the putative anxiolytic activity of G.elata Bl. has not been scientifically investigated. Therefore, the present study was designed to assess anxiolytic property and interaction with benzodiazepine receptor of G. elata BI. The putative anxiolytic activity of ethanol extract of G. elata BI. was performed in mice using an elevated plus maze paradigm. Chronic oral administration of G. elata BI. showed anxiolytic action in mice. It was suggested that regulation of GABAergic neurotarnsmission may be important in the action of G. elata BI. The interaction of G. elata BI. with benzodiazepine receptor was investigated using rat cortices. Ethanol extract of G. elata inhibited the binding of [³H] Ro15-1788, a selective benzodiazepine receptor antagonist to benzodiazepine receptor. The inhibition of [³H] Ro15-1788 binding by G. elata BI. appeared to be competitive. Further, GABA significantly enhanced the potency of this extract in inhibiting [³H] flunitrazepam, a selective benzodiazepine receptor agonist, binding to benzodiazepine receptor. From these findings, it can be concluded that substance or substances with neurochemical properties characteristic of a benzodiazepine receptor agonist may contribute to the anxiolytic property of G. elata BI.

Streptozotocin으로 유발된 당뇨병쥐의 신경전도속도에 대한 Evening primrose oil (EPO), Vit.C, Vit.E의 약물효과

신창열,류정수,김학림,강봉수,손의동,허인회 중앙대학교 약학연구소 1997 약학 논총 Vol.11 No.-

The effects of evening primrose oil (EPO). Vit.C and Vit.E on nerve conduction velocity (NCV) in streptozotocin -induced diabetic rats were investigated. 5 weeks- diabetes caused 27±0.5 % reduction in sciatic motor conduction velocity as compared with normal control. Dietary supplement of 5% EPO. 125mg/kg Vit.C. and lg/kg Vit.E prevented significantly the development of the motor nerve conduction velocity deficit about 21±0.5, 21±0.5, 26±0.5% respectively. The total serum cholesterol and triglyceride were decreased by administration 5% EPO. Vit.C, and Vit.E as compared with diabetic control. However, the serum glucose was not decreased by administration 5% EPO. 125mg/kg Vit.C but the serum glucose was decreased by administration lg/kg Vit.E as compared with diabetic control.

Hepatoprotective Effects of Ginseng Intestinal Metabolite IH-901 on Chemical-Induced Hepatic Damage

Uy Dong Sohn,Sung Kwon Ko,Tae Sik Choi,Byung Ok Im,Sung Tai Han,Byung Wook Yang,Jong Hwan Sung,Yong Sung Kim,Jae Gwang Woo,Young Rae Cho,Young Sil Min,Ji Hoon Jeong,Boo Yong Lee 한국식품과학회 2005 Food Science and Biotechnology Vol.14 No.4

A Case Study of Sand Production Prediction for a Wellbore Drilled in Cuu Long Basin, Vietnam

( Uy Vo ),( Chandong Chang ) 대한지질공학회 2016 대한지질공학회 학술발표회논문집 Vol.2016 No.1

Sand production is a type of wellbore rock failure process that causes a variety of borehole problems in petroleum industry such as stuck pipe, tubing erosion and well collapse. Thus we have to avoid sand production by controlling wellbore pressure for given ambient conditions such as stress states and rock strength. To predict excessive sand production, petroleum industry and science community have previously attempted a variety of techniques such as production history observation, mechanical property analysis, laboratory testing and computer modeling. In this study, we use poroelasticity theory to predict sand production in a wellbore drilled in Cuu-long basin, southeast Vietnam. The wellbore is 3873 m deep (TVD and 4471 m MD), penetrating into Oligocene sandstone formations. The sandstones are well cemented and consolidated with a UCS (unconfined compressive strength) range between 12 and 90 MPa. Since the rock formations are generally strong, we expect that there would be no severe sand production. Since the cased borehole required perforations to enhance the productivity, however, it is beneficial to investigate the sand production potential at the perforation depths. To that end, we used a geomechanical model including the stress states in formations and rock strength to find out the specific depths where sands would spall out into the wellbore. Based on this result, drillers carried out perforation process only at depths where sand production potential is extremely low. To make sure whether these perforation depths are stable regarding sand production, we estimated the lower limits of wellbore pressure (Pw) that would prevent sand production for given formation pressures. The calculated lower Pw limit was determined to be close to zero, suggesting that the sanding-free zones are quite stable. We also investigated the effect of wellbore trajectory on sand production. The results demonstrate that as the wellbore deviates towards horizontal, the sand production potential becomes high, indicating the importance of well trajectory for wellbore stability.

Geomechanical characterization of sedimentary basins using tectonic stress and strai

Uy D. Vo,장찬동 한국지질과학협의회 2020 Geosciences Journal Vol.24 No.6

We examine whether the combination of tectonic stress and strain is useful in characterizing tectonic condition and geomechanics of sedimentary basins. We compile measured stress, pore pressure, and mechanical rock property data from six major sedimentary basins worldwide. We find that the measured horizontal principal stresses are always higher than the theoretically calculated stresses based on a simple uniaxial compaction poroelastic equation, known as Eaton’s model. From this we conclude that there are always external tectonic stresses in seemingly stable basins. We extract these external tectonic stresses by subtracting the theoretically calculated horizontal stresses from the measured horizontal stresses, and relate them to the tectonic strains estimated by the linear elastic constitutive model. Given the external tectonic stresses and associated strains, we interpret the tectonic conditions of individual basins from the tectonic differential stress and strain conditions. The six basins exhibit distinct tectonic stress and strain regimes, which can be related generally to geological processes such as brittle and ductile deformation. The results show that combining tectonic stress and strain is useful in characterizing sedimentary basins.