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( Usanee Aimsiranun ) 한국EU학회 2019 Asia-Pacific Journal of EU Studies Vol.17 No.1
The Court of Justice of the European Union’s case law has been a vector of social integration of mobile EU citizens in the host Member State, independent of their economic status. Conciliating EU primary and secondary legislation, which, on the one hand, confers rights to move and reside and to equal treatment regarding social benefits, and, on the other hand, lays down the conditions and limitations of the exercise of such rights, the Court has adopted a creative and flexible approach in order to ensure social protection to inactive EU citizens who use their right to move. The economic crisis and the rising concern about welfare tourism in Europe have nevertheless led to a greater tension between the right to social protection conferred at EU level and the expenses of the welfare state at the national level. This paper analyzes the Court’s case law, prior to and after the entry into force of Directive 2004/38, which regulates EU citizens’ right to reside and to equal treatment, in order to assess the extent and conditions of the right to social protection for inactive mobile citizens. The shift of the Court’s approach in the post-Directive 2004/38 case law has resulted in a more rigid interpretation of the conditions and limitations of the right to social benefits of inactive EU citizens in the host Member State.
( Usanee Ungcharoen¸ B. Pharm ),( Hutcha Sriplung ),( Surakameth Mahasirimongkol ),( Saranyou Chusri ),( Nuanjun Wichukchinda ),( Phongpan Mokmued ),( Sukanya Wattanapokayakit ),( Virasakdi Chongsuviv 대한결핵 및 호흡기학회 2020 Tuberculosis and Respiratory Diseases Vol.83 No.-
Background: Isoniazid (INH) is metabolized by polymorphic N-acetyltransferase 2 (NAT2 ) enzyme, which noticeably alters INH plasma concentration. We aimed to determine the distribution of NAT2 genotype in Thai tuberculosis (TB) patients and correlate their genotype with plasma INH concentrations. Methods: Blood samples from 55 newly diagnosed pulmonary tuberculosis participants from three hospitals were collected to classify the subject by NAT2 genotype performed by the Multiplex haplotype-specific polymerase chain reaction method. Patients were grouped into three acetylators (fast, intermediate, and slow). On day 14 of tuberculosis treatment, the second blood sample was taken to estimate the peak plasma concentration at 2 hours after oral administration. INH plasma concentration was analyzed by liquid chromatography-tandem mass spectrometry/mass spectrometry method. Results: The NAT2 genotype distribution of fast, intermediate, and slow acetylator was 10.9%, 36.4%, and 52.7%, from six, 20, and 29 patients, respectively. The median (interquartile range) of INH plasma concentration at 2 hours post drug administration for these three genotypes were 0.75 (0.69-0.86), 2.56 (2.12-3.97), and 4.25 (3.56-5.50) μg/mL from four, 14, and 12 cases, respectively. The INH plasma concentration at 2 hours after administration was significantly associated with body weight and NAT2 acetylator. Conclusion: The INH plasma concentration was found lower in fast than intermediate and slow acetylators. Body weight and NAT2 acetylator influenced INH plasma concentrations at 2 hours after drug administration. Therefore, the NAT2 genotype should be known before starting TB treatment to maximize therapeutic outcomes.
Chatchotikawong, Usanee,Ruengkhachorn, Irene,Leelaphatanadit, Chairat,Phithakwatchara, Nisarat Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Purpose: To determine the rate of lymph node metastasis, oncologic and pregnancy outcomes in apparent early-stage malignant ovarian germ cell tumor (MOGCT). Materials and Methods: Medical records of apparent early-stage MOGCT patients undergoing primary surgical treatment at Siriraj Hospital, Bangkok, Thailand, between January 2006 and December 2013, were retrospectively reviewed. Results: Thirty-eight patients had apparent stage I-II MOGCT. The mean age was $22.1{\pm}7.7years$ (median, 20.8 years; range, 7.7-35.6 years). The mean tumor size was $17.8{\pm}6.5cm$ with a median of 20 (range 4-30) cm. Three most common histopathologies were dysgerminoma (12 patients, 31.6%), immature teratoma (12 patients, 31.6%), and endodermal sinus tumor (6 patients, 15.8%). Twenty-seven of 38 patients underwent lymphadenectomy; 13 patients (48.2%) were stage IA and 8 patients (29.6%) were stage IC. The rate of retroperitoneal nodes metastasis was 7.4% (2/27 patients). At 26.1 months of median follow-up time (range 1.9-88.5 months), 9 patients retained fertility functions, with uneventful pregnancies in 3 of these. Only one patient (2.6%) had progression of disease at 4.9 months after surgery. The 5-year survival rate was 97.4%. Conclusion: As the rate of pelvic or para-aortic node metastasis in MOGCT is considerable, lymphadenectomy should be incorporated in surgical staging procedures.
Chatchotikawong, Usanee,Ruengkhachorn, Irene,Leelaphatanadit, Chairat Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: To determine rates of residual disease along with influencing factors in women with stage IA to IB1 cervical carcinoma after conization. Materials and Methods: A retrospective study was conducted of medical records of 198 stage IA to IB1 cervical carcinoma patients who had undergoing cervical conization followed by primary surgical treatment during 2006-2013. Independent factors correlating with residual carcinoma in subsequent surgical specimens were analyzed by stepwise regression analysis. Results: Mean age was 48.9 years. Cone specimens demonstrated free margins in 36 women (18.8%). In case of having disease at margin, high-grade cervical intraepithelial neoplasia (CIN) and carcinoma were evidenced in 58 and 97 women, respectively. Pathology of subsequent specimens revealed residual carcinoma in 78 women (39.4%), high-grade CIN or adenocarcinoma in situ (AIS) in 45 (22.7%), and no residual pathology in 75 (37.9%). Age more than 35 years, postmenopausal status, having symptoms, diseases or invasive lesions at conization margins or disease on endocervical aspect, and higher stage were significantly correlated with residual cancer in surgical treatment specimens. On regression analysis, postmenopause and stage were independent factors associated with residual carcinoma.Conclusions: Patient and tumor characteristics are predictive factors for residual cancer in the studied group of women.
Sanmee, Usanee,Piromlertamorn, Waraporn,Vutyavanich, Teraporn The Korean Society for Reproductive Medicine 2016 Clinical and Experimental Reproductive Medicine Vol.43 No.3
Objective: We studied the effect of the site of laser zona opening on the complete hatching of mouse blastocysts and the cell numbers of the completely hatched blastocysts. Methods: Mouse blastocysts were randomly allocated to the inner cell mass (ICM) group (zona opening performed at the site of the ICM, n=125), the trophectoderm (TE) group (zona opening performed opposite to the ICM, n=125) and the control group (no zona opening, n=125). Results: The rate of complete hatching of the blastocysts was not significantly different in the ICM and the TE group (84.8% vs 80.8%, respectively; p=0.402), but was significantly lower in the control group (51.2%, p<0.001). The cell numbers in the completely hatched blastocysts were comparable in the control group, the ICM group, and the TE group ($69{\pm}19.3$, $74{\pm}15.7$, and $71{\pm}16.8$, respectively; p=0.680). Conclusion: These findings indicate that the site of laser zona opening did not influence the rate of complete hatching of mouse blastocysts or their cell numbers.
Rapid freezing versus Cryotop vitrification of mouse two-cell embryos
Inna, Namfon,Sanmee, Usanee,Saeng-anan, Ubol,Piromlertamorn, Waraporn,Vutyavanich, Teraporn The Korean Society for Reproductive Medicine 2018 Clinical and Experimental Reproductive Medicine Vol.45 No.3
Objective: To compare our in-house method of embryo freezing with Cryotop vitrification in terms of immediate survival, subsequent cleavage and blastocyst formation, and cell numbers in blastocysts. Methods: Two-cell mouse embryos were randomly allocated into three groups: a non-frozen control group (group 1, n = 300), a group that underwent Cryotop vitrification (group 2, n = 300), and a group that underwent our in-house freezing method (group 3, n = 300). Results: There were no significant differences between groups 2 and 3 in the immediate survival rate (96.3% vs. 98.6%, respectively; p= 0.085), the further cleavage rate (91.7% vs. 95.0%, respectively; p= 0.099), or the blastocyst formation rate (80.7% vs. 78.6%, respectively; p= 0.437). The cell numbers in the blastocysts from groups 1, 2, and 3 were comparable ($88.99{\pm}10.44$, $88.29{\pm}14.79$, and $86.42{\pm}15.23$, respectively; p= 0.228). However, the percentage of good-quality blastocysts in the Cryotop vitrification group was significantly higher than in the group in which our in-house method was performed, but was lower than in the control group (58.0%, 37.0%, and 82.7%, respectively; p< 0.001). Conclusion: At present, our method is inferior to the commercial Cryotop vitrification system. However, with further improvements, it has the potential to be useful in routine practice, as it is easier to perform than the current vitrification system.
Investigation on the Electrical Discharge Characteristics of a Unipolar Corona-Wire Aerosol Charger
Panich Intra,Artit Yawootti,Usanee Vinitketkumnuen,Nakorn Tippayawong 대한전기학회 2011 Journal of Electrical Engineering & Technology Vol.6 No.4
In the present study, a simple corona-wire charger for unipolar diffusion charging of aerosol particles is designed, constructed, and characterized. Experimental characterizations of the electrostatic discharge in terms of current-voltage relationships of positive and negative coronas of the corona-wire charger are also presented and discussed. The charging current and ion concentration in the charging zone increased monotonically with corona voltage. The negative corona showed higher current than the positive corona. At the same corona voltages, the current in the discharge zone is about 600 times larger than the charging current. The ion number concentrations ranged within approximately 5.0 × 10¹? to 1.24 × 10¹? and 4.5 × 10¹² to 2 × 10¹? ions/㎥ in the discharge and charging zones, respectively. A numerical model is used to predict the behavior of the electric potential lines. Numerical results of ion penetration through the inner electrode are in good agreement with the experimental results.
Development of a PM2.5 sampler with inertial impaction for sampling airborne particulate matter
Panich Intra,Artit Yawootti,Usanee Vinitketkumnuen,Nakorn Tippayawong 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.8
A simple and low cost PM2.5 impactor for sampling airborne particulate matter was developed, designed and evaluated. The design was an assembly of an acceleration nozzle and an impaction plate. Particles with sufficient inertia were unable to follow air streamlines and impacted on the plate. Smaller particles followed the streamlines, avoided being captured by the plate and could then be collected on a downstream filter. Analytical and numerical models were formulated to predict collection efficiency, flow fields and vectors, and particle trajectories in the impactor. The modeling suggested that an optimal operational domain exists for the PM2.5 impactor. A prototype was then built and tested. The collected particles on the impaction plate and downstream of the PM2.5 impactor were analyzed by using scanning electron microscopy. Experimental results agreed well with the theoretical predictions. Testing of the PM2.5impactor prototype showed promising results for this airborne particulate matter sampler.
Tana, Chonthicha,Somsak, Pareeya,Piromlertamorn, Waraporn,Sanmee, Usanee The Korean Society for Reproductive Medicine 2022 Clinical and Experimental Reproductive Medicine Vol.49 No.1
Objective: We investigated the effect of supplementing fertilization medium and/or culture medium with astaxanthin (AST) on the two phases of in vitro fertilization: gamete fertilization and embryo development. Methods: Mouse cumulus-oocyte complexes were divided into four groups with 5 µM AST added to the fertilization medium (group 3, n=300), culture medium (group 2, n=300), or both media (group 4, n=290). No AST was added to the control group (group 1, n=300). Results: The fertilization rate was significantly higher (p<0.001) in the groups using AST supplemented fertilization medium (group 3, 79.0%; group 4, 81.4%) than those without AST (group 1, 56.3%; group 2, 52.3%). The blastocyst rate calculated from the two-cell stage was significantly lower (p<0.001) in the groups using AST-supplemented embryo culture medium (group 2, 58.0%; group 4, 62.3%) than in those without AST (group 1, 82.8%; group 3, 79.8%). The blastocyst rate calculated from the number of inseminated oocytes was highest in group 3 (189/300, 63.0%) and lowest in group 2 (91/300, 30.3%) with statistical significance compared to other groups (p<0.001). There were significantly higher numbers of cells in the inner cell mass and trophectoderm, as well as significantly higher total blastocyst cell counts, in group 3 than in the control group. Conclusion: An increased blastocyst formation rate and high-quality blastocysts were found only in the fertilization medium that had been supplemented with AST. In contrast, AST supplementation of the embryo culture medium was found to impair embryo development.