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Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
( Yong Dae Kwon ),( Hoon Jai Chun ),( Soon Ho Um ),( Chang Duck Kim ),( Ho Sang Ryu ),( Yoon Tae Jeen ),( Jin Su Jang ),( Ju Young Kim ),( Chul Young Kim ),( Sang Hoon Park ),( Bora Keum ),( Yeon Seok 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Screening guideline for colorectal cancer in average-risk asymptomatic population recommends colonoscopy starting at age 50. One prior study has reported the prevalence and low cost-effectiveness of colorectal neoplasia with colonoseopic screening in asymptomatic population aged 40-49 (Imperale et al.). However, recently colonoscopic detection rate of colorectal cancer of young age (<50) is increasing. Therefore, we investigated the prevalence of advanced neoplasia with colonoscopy according to age and evaluated the optimal age of screening colonoscopy. Methods: We reviewed the medical records of average-risk asymptomatic 1.745 persons performed screening colonoscopy from January 2001 to December 2006 in Korea university medical center. High risk patients (family history of cancer, IBD, previous history of adenoma) were excluded. Advanced neoplasia was defined as tubular adenoma measuring 1 cm or larger, any villous histology, high grade dysplasia, or cancer. Results: Overall prevalence of colorectal adenoma was 38.9% (679 of 1,744) and prevalence of advanced adenoma was 2.06% (36 of 1.744). Of the 489 persons in the 40-49 age group, 127 (25.97%) had one or more adenomas, and 6 (1.23%) had an advanced neoplasia, 2 (0.41%) had cancer. Of the 633 persons in the 50-59 age group, 270 (42.65%) had one or more adenomas, and 9 (1.42%) had an advanced neoplasia, 3 (0.47%) had cancer. Conclusions: The prevalence of advanced neoplasia in 40-49 and 50-59 age groups was lower than previous study. However, our study shows similar prevalence of advanced neoplasia between 40-49 and 50-59 age groups. Therefore, we should consider screening colonoscopy for early colorectal cancer earlier than 50 in average-risk asymptomatic population.
Proteomic Analysis of Antibodies Against H. pylori Proteins in Sera of Chronic Gastritis Patients
( Yong Sik Kim ),( Hoon Jai Chun ),( Rok Son Choung ),( Yoon Tae Jeen ),( Hong Sik Lee ),( Soon Ho Um ),( Sang Woo Lee ),( Jai Hyun Choi ),( Chang Duck Kim ),( Ho Sang Ryu ),( Eun Kyung Park ),( Chang 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<Background> Even though the good antibiotics are available for H. pylori eradication, H. pylori is still one of the major pathogens in gastroenterology. To improve the validity of diagnosis, treatment and even vaccine production, identification of bacter
Scanning Electron Microscopic Evaluation of Interaction between Helicobactor pylori and AGS Cells
( Yong Sik Kim ),( Hoon Jai Chun ),( Rok Son Choung ),( Yoon Tae Jeen ),( Chang Sub Uhm ),( Hong Sik Lee ),( Soon Ho Um ),( Sang Woo Lee ),( Jai Hyun Choi ),( Chang Duck Kim ),( Ho Sang Ryu ),( Jin Ha 대한내과학회 2003 대한내과학회 추계학술대회 Vol.65 No.10
( Sang Hoon Ahn ),( Won Kim ),( Young Kul Jung ),( Jin Mo Yang ),( Jae Young Jang ),( Yong Oh Kweon ),( Yong Kyun Cho ),( Yoon Jun Kim ),( Gun Young Hong ),( Dong Joon Kim ),( Soon Ho Um ),( Joo Hyun 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Besifovir is an acyclic nucleotide phosphonate known to be effective in hepatitis B virus (HBV) DNA suppression for both treatment- naïve and lamivudine-resistant chronic HBV infection in preliminary studies. We assessed the safety and efficacy of besifovir comparing with tenofovir in treatment-naïve chronic hepatitis B patients. Methods: A total of 187 patients were randomly received besifovir dipivoxil 150mg or tenofovir disoproxil fumarate 300mg. Eligible subjects were patients with chronic HBV infection. We measured the proportion of patients who had HBV DNA less than 69 IU/mL at week 48 as the primary efficacy endpoint. Key secondary endpoints were histological response (i.e., a reduction in the Knodell necroinflammation score of 2 or more points without worsening fibrosis), serum HBV DNA reduction, and liver function tests. Also, bone mineral density (BMD) and renal parameters were evaluated. Results: The proportion of patients who achieved primary endpoint of HBV DNA (< 69 IU/mL) at week 48 were 85.33% and 88.75% among those who received besifovir and tenofovir, respectively. Besifovir was shown to be non-inferior to tenofovir (lower limit of 95% CI for the treatment difference =-0.14). Histological improvement of 29 patients who underwent liver biopsy was evaluated, and we found that significantly more patients treated with besifovir had improved histological response than those treated with tenofovir (77.78% vs. 36.36%, p=0.0482). There was no difference in intrahepatic cccDNA reduction between the two groups (p=0.35). None of the patients had resistant to mutations or increase in serum creatinine >0.5mg/dL from baseline. Patients who received besifovir had smaller decrease in BMD during 48 weeks than that of tenofovir (besifovir -0.02±0.44, tenofovir -0.10±0.86, p=0.0248). There was no adverse drug reaction leading the patients to withdrawal. Conclusions: This phase 3 study demonstrated that besifovir had comparable efficacy and safety profile to tenofovir in the treatment of treatment-naïve chronic hepatitis B patients. Besifovir showed better profile than tenofovir in both histological response and bone loss. An open-label extension study is ongoing with besifovir to investigate long-term efficacy and safety.
Effects of EGF Receptor Antagonist (AG1478) on Helicobacter pylori Infected AGS Cells
( Yong Sik Kim ),( Hoon Jai Chun ),( Rok Son Choung ),( Yoon Tae Jeen ),( Chang Sub Uhm ),( Hong Sik Lee ),( Soon Ho Um ),( Sang Woo Lee ),( Jai Hyun Choi ),( Chang Duck Kim ),( Ho Sang Ryu ),( Jin Ha 대한내과학회 2003 대한내과학회 추계학술대회 Vol.65 No.10
Biomass Waste, Coffee Grounds-derived Carbon for Lithium Storage
Um, Ji Hyun,Kim, Yunok,Ahn, Chi-Yeong,Kim, Jinsoo,Sung, Yung-Eun,Cho, Yong-Hun,Kim, Seung-Soo,Yoon, Won-Sub The Korean Electrochemical Society 2018 Journal of electrochemical science and technology Vol.9 No.3
Biomass waste-derived carbon is an attractive alternative with environmental benignity to obtain carbon material. In this study, we prepare carbon from coffee grounds as a biomass precursor using a simple, inexpensive, and environmentally friendly method through physical activation using only steam. The coffee-derived carbon, having a micropore-rich structure and a low extent of graphitization of disordered carbon, is developed and directly applied to lithium-ion battery anode material. Compared with the introduction of the Ketjenblack (KB) conducting agent (i.e., coffee-derived carbon with KB), the coffee-derived carbon itself achieves a reversible capacity of ~200 mAh/g (0.54 lithium per 6 carbons) at a current density of 100 mA/g after 100 cycles, along with excellent cycle stability. The origin of highly reversible lithium storage is attributed to the consistent diffusion-controlled intercalation/de-intercalation reaction in cycle life, which suggests that the bulk diffusion of lithium is favorable in the coffee-derived carbon itself, in the absence of a conducting agent. This study presents the preparation of carbon material through physical activation without the use of chemical activation agents and demonstrates an application of coffee-derived carbon in energy storage devices.
( Sang Hoon Park ),( Hoon Jai Chun ),( Yong Dae Kwon ),( Bo Ra Keum ),( Yeon Seok Seo ),( Yong Sik Kim ),( Yoon Tae Jeen ),( Soon Ho Um ),( Chang Duck Kim ),( Ho Sang Ryu ),( Ji Hye Lee ),( Yang Seok 대한소화기학회 2008 Gut and Liver Vol.2 No.3
Background/Aims: Endoscopic mucosal resection can cure early gastric cancer. The risk of lymphatic metastasis is related to the depth of submucosal invasion by the mucosal malignancy, with a resection depth of 500 μm generally accepted as a safe cut-off. However, excessive thinning induced by stretching of the resected tissue sometimes preventing a precise diagnosis. We studied the effects of stretching on different layers and sites of gastric tissue. Methods: Porcine stomachs were cut into 2.0×2.0 cm pieces, and pieces from body were stretched to 2.5, 3.0, and 3.5 cm. Pieces from the cardia, body, and antrum were also stretched to 3.0 cm. The thickness of each layer was measured and analyzed statistically. Results: Whole gastric wall and submucosal layers showed gradual thinning, with stretching to 3.5 cm tearing the tissues and resulting in imperfect extension. The submucosa was thinner in body tissue than in cardia and antrum tissues. Stretching to 3.0 cm induced a consistent decrease in submucosal thickness (30-70%). The change in thickness varied widely between individual samples. Conclusions: A resection margin of 500μm might be insufficient for the complete removal of malignancy. Moreover, the thickness of the submucosal layer differs with the gastric site and between individuals. Future studies are needed to confirm the findings in human tissue. (Gut and Liver 2008;2:199-204)
Comparison of Proteome between Bacillary and Coccoid Form of Helicobacter pylori
( Yong Sik Kim ),( Hoon Jai Chun ),( Rok Son Choung ),( Yoon Tae Jeen ),( Hong Sik Lee ),( Soon Ho Um ),( Sang Woo Lee ),( Jai Hyun Choi ),( Chang Duck Kim ),( Ho Sang Ryu ),( Sang Hoon Lee ),( Chang 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<Background> It is well known that H. pylori takes two forms depending on the environment and nutritional states. The conversion of bacillary to coccoid form occurs in the harsh environment, however the reverse is in question. In this study, the proteomes