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쥐의 조직을 이용한 glutamine 선택성 sensor 개발에 관한 연구
김의락,손병기,임동준,배진현,최성문 경북대학교 센서기술연구소 1991 센서技術學術大會論文集 Vol.2 No.1
The various types of enzyme have been coupled to ion-selective electrodes for the development of enzyme membrane electrodes. The tissue and organ of animals and plants contained a lot of variant enzymes. A bioselsoective membrane electrode which employs slices of Wistar rat liver was studied that the effect of pH, kinds and concentration of buffer solution, temperature and thickness of slice in order to optimize electrode response. The longstability, the response time and slope of wistar rat tissue glutamine selective membrane electrode was evaluated.
( Ui Hyeon Jo ),( Jung Min Moon ),( Jin Yong Lee ),( Seong-joon Koh ),( Sungchan Kang ),( Hosim Soh ),( Hyun Jung Lee ),( Jong Pil Im ),( Joo Sung Kim ),( Hyunsun Park ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Emerging data suggest that inflammatory bowel disease (IBD) and psoriasis are associated, sharing common genetic predispositions and immunologic mechanisms. Objectives: We aimed to investigate the risk of developing psoriasis in IBD patients compared to controls without IBD. Methods: Using the Korean insurance data, patients diagnosed with Crohn’s disease(CD) or ulcerative colitis(UC) between 2005 and 2008 were age- and sex-matched 1:4 to non-IBD subjects from 2003 to 2018. We investigated newly diagnosed psoriasis from 2009 to 2018. Incidence rates were calculated and risk of psoriasis was assessed with multivariate cox regression models. Results: During nearly a decade of follow-up, 20,152 IBD patients were identified [14,619 UC and 5,533 CD]. Among them, 439 patients were newly diagnosed with psoriasis (incidence rate of 217.68 and 228.62 per 100,000 person-years for UC and CD, respectively). The psoriasis risk was higher in IBD patients than in the matched controls (aHR 2.95, 95% CI 2.60-3.33). Moreover, IBD patients aged <30 years were at a higher risk (aHR 3.35; 95% CI, 2.58-4.35). Sensitivity analysis of tumor necrosis factor inhibitor-naïve patients revealed consistent results. Conclusion: IBD patients were more likely to develop psoriasis compared to non-IBD subjects, with younger patients at a particular risk. Inspection of cutaneous manifestation and dermatological consultation may be helpful in IBD patients at risk.
( Ui Hyeon Jo ),( Jin Yong Lee ),( Hanjae Lee ),( Do-yeop Kim ),( Sungchan Kang ),( Seong-joon Koh ),( Hyunsun Park ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Inflammatory bowel disease (IBD) presents with various extraintestinal manifestations, especially skin diseases. Objectives: We aimed to identify the epidemiology and risk of developing skin manifestations in patients with IBD. Methods: We used Korean National Health Insurance Claims database and selected patients with IBD and age/sex-matched non-IBD subjects using the diagnosis code and prescription records of IBD-specific medications from 2013 to 2017. The prevalence and risk of concurrent skin diseases were estimated. Results: A total of 64,837 patients with IBD was identified. Among 3 categories of reactive, inflammatory, and autoimmune skin diseases, reactive skin eruptions including pyoderma gangrenosum and erythema nodosum were associated with IBD with highest odds ratios. Inflammatory skin diseases including rosacea, psoriasis, atopic dermatitis, hidradenitis suppurativa, and acne conglobata were significantly associated with IBD. The patients with IBD also had a higher risk of autoimmune skin diseases including vitiligo and alopecia areata than non-IBD subjects. Conclusion: This population-based study suggests that IBD was related to various skin diseases including reactive, inflammatory, and autoimmune skin diseases. Considering these relationships can allow better management of patients with IBD and comorbid skin diseases.