Is percutaneous destruction of a solitary liver colorectal metastasis as effective as a resection?

Ugo Marchese,Heloise Seux,Jonathan Garnier,Jacques Ewald,Gilles Piana,Bernard Lelong,Cecile De Chaisemartin,Helene Meillat,Jean-Robert Delpero,Olivier Turrini 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.2

Backgrounds/Aims: Surgical resection remains the gold standard in the treatment of colorectal liver metastasis. However, when a patient presents with a deep solitary colorectal liver metastasis (S-CLM), the balance between the hepatic volume sacrificed and the S-CLM volume is sometimes clearly unappropriated. Thus, alternatives to surgery, such as operative and percutaneous radiofrequency ablation (RFA) and microwave ablation (MWA), have been developed. This study aimed to identify the prognostic factors affecting survival of patients with S-CLM who undergo curative-intent liver resection or local destruction (RFA or MWA). Methods: We retrospectively identified 211 patients with synchronous or metachronous S-CLM who underwent either surgical resection (n=182) or local destruction (RFA or MWA; n=29) according to the S-CLM size, location, and surrounding Glissonian structures. Results: Patients who underwent RFA or MWA had S-CLM of a smaller size than those who underwent resection (mean 19.7 vs. 37.3 mm, p<.01). The 1-, 3-, and 5-year overall survival (OS) rates were 97.4%, 84.9%, and 74.9%, respectively. The 1-, 3-, and 5-year disease-free survival (DFS) rates were 77.9%, 47%, and 38.9%, respectively. S-CLM located in the left liver (p=.04), S-CLM KRAS mutation (p<.01), and extra-hepatic recurrence (p<.01) were identified as independent poor risk factors for overall survival (OS); the OS and DFS were comparable in patients with surgical procedure or percutaneous MWA. Conclusions: In eligible S-CLM cases, percutaneous MWA seems to be as oncologically efficient as surgical resection and should be include in the decision-tree for treatment strategies.

경제가 민족주의를 설명해 줄 수 있을까?

Ugo Pagano,임성배 경기대학교 사회과학연구소 2001 한국사회연구 Vol.4 No.-

Extension of a new tailoring optimisation technique to sandwich shells with laminated faces

Ugo Icardi 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.43 No.6

The tailoring optimization technique recently developed by the author for improving structural response and energy absorption of composites is extended to sandwich shells using a previously developed zig-zag shell model with hierarchic representation of displacements. The in-plane variation of the stiffness properties of plies and the through-the thickness variation of the core properties are determined solving the Euler-Lagrange equations of an extremal problem in which the strain energy due to out-of-plane strains and stresses is minimised, while that due to their in-plane counterparts is maximised. In this way, the energy stored by unwanted out-of-plane modes involving weak properties is transferred to acceptable in-plane modes. As shown by the numerical applications, the critical interlaminar stress concentrations at the interfaces with the core are consistently reduced without any bending stiffness loss and the strength to debonding of faces from the core is improved. The structural model was recently developed by the author to accurately describe strain energy and interlaminar stresses from the constitutive equations. It a priori fulfills the displacement and stress contact conditions at the interfaces, considers a second order expansion of Lame’s coefficients and a hierarchic representation that adapts to the variation of solutions. Its functional d.o.f. are the traditional mid-plane displacements and the shear rotations, so refinement implies no increase of the number of functional d.o.f. Sandwich shells are represented as multilayered shells made of layers with different thickness and material properties, the core being treated as a thick intermediate layer.

Marine gas turbine monitoring and diagnostics by simulation and pattern recognition

Ugo Campora,Carlo Cravero,Raphael Zaccone 대한조선학회 2018 International Journal of Naval Architecture and Oc Vol.10 No.5

Several techniques have been developed in the last years for energy conversion and aeronautic propulsion plants monitoring and diagnostics, to ensure non-stop availability and safety, mainly based on machine learning and pattern recognition methods, which need large databases of measures. This paper aims to describe a simulation based monitoring and diagnostic method to overcome the lack of data. An application on a gas turbine powered frigate is shown. A MATLAB-SIMULINK® model of the frigate propulsion system has been used to generate a database of different faulty conditions of the plant. A monitoring and diagnostic system, based on Mahalanobis distance and artificial neural networks have been developed. Experimental data measured during the sea trials have been used for model calibration and validation. Test runs of the procedure have been carried out in a number of simulated degradation cases: in all the considered cases, malfunctions have been successfully detected by the developed model.

Robustness and resilience of a passive control solution assembling buffer and cladding panels

Ugo Balzari,Andrea Balzari 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.20 No.5

The adoption of cladding panels as dissipation device is a sort of passive control \"ante litteram\" for residential and commercial buildings. This paper gives details on the current technology outlining the difference between buffer panels and cladding panels. The discussion of robustness and resilience of the resulting system is afforded. It is shown that the strength of such solution, originally related to economy and light weight, is mainly associated with the respect of the main robustness requisites, as well as the short time it requires for removal and replacement (resilience).

Marine gas turbine monitoring and diagnostics by simulation and pattern recognition

Campora, Ugo,Cravero, Carlo,Zaccone, Raphael The Society of Naval Architects of Korea 2018 International Journal of Naval Architecture and Oc Vol.10 No.5

Several techniques have been developed in the last years for energy conversion and aeronautic propulsion plants monitoring and diagnostics, to ensure non-stop availability and safety, mainly based on machine learning and pattern recognition methods, which need large databases of measures. This paper aims to describe a simulation based monitoring and diagnostic method to overcome the lack of data. An application on a gas turbine powered frigate is shown. A MATLAB-SIMULINK(R) model of the frigate propulsion system has been used to generate a database of different faulty conditions of the plant. A monitoring and diagnostic system, based on Mahalanobis distance and artificial neural networks have been developed. Experimental data measured during the sea trials have been used for model calibration and validation. Test runs of the procedure have been carried out in a number of simulated degradation cases: in all the considered cases, malfunctions have been successfully detected by the developed model.

Cylindrical bending of laminated cylindrical shells using a modified zig-zag theory

Icardi, Ugo Techno-Press 1998 Structural Engineering and Mechanics, An Int'l Jou Vol.6 No.5

A relatively simple two-dimensional multilayered shell model is presented for predicting both global quantities and stress distributions across the thickness of multilayered thick shells, that is based on a third-order zig-zag approach. As for any zig-zag model, the layerwise kinematics is accounted for, with the stress continuity conditions at interfaces met a priori. Moreover, the shell model satisfies the zero transverse shear stress conditions at the upper and lower free surfaces of the shell, irrespective of the lay-up. By changing the parameters in the displacement model, some higher order shell models are obtained as particular cases. Although it potentially has a wide range of validity, application is limited to cylindrical shell panels in cylindrical bending, a lot of solutions of two-dimensional models based on rather different simplyfying assumptions and the exact three-dimensional elasticity solution being available for comparisons for this benchmark problem. The numerical investigation performed by the present shell model and by the shell models derived from it illustrates the effects of transverse shear modeling and the range of applicability of the simplyfying assumptions introduced. The implications of retaining only selected terms depending on the radius-to-thickness ratio are focused by comparing the present solutions to the exact one and to other two-dimensional solutions in literature based on rather different simplyfying assumptions.

Extension of a new tailoring optimisation technique to sandwich shells with laminated faces

Icardi, Ugo Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.43 No.6

The tailoring optimization technique recently developed by the author for improving structural response and energy absorption of composites is extended to sandwich shells using a previously developed zig-zag shell model with hierarchic representation of displacements. The in-plane variation of the stiffness properties of plies and the through-the thickness variation of the core properties are determined solving the Euler-Lagrange equations of an extremal problem in which the strain energy due to out-of-plane strains and stresses is minimised, while that due to their in-plane counterparts is maximised. In this way, the energy stored by unwanted out-of-plane modes involving weak properties is transferred to acceptable in-plane modes. As shown by the numerical applications, the critical interlaminar stress concentrations at the interfaces with the core are consistently reduced without any bending stiffness loss and the strength to debonding of faces from the core is improved. The structural model was recently developed by the author to accurately describe strain energy and interlaminar stresses from the constitutive equations. It a priori fulfills the displacement and stress contact conditions at the interfaces, considers a second order expansion of Lame's coefficients and a hierarchic representation that adapts to the variation of solutions. Its functional d.o.f. are the traditional mid-plane displacements and the shear rotations, so refinement implies no increase of the number of functional d.o.f. Sandwich shells are represented as multilayered shells made of layers with different thickness and material properties, the core being treated as a thick intermediate layer.

Interaction Metaphors for Modeling Virtual Hair using Haptic Interfaces

Bonanni, Ugo,Kmoch, Petr,Magnenat-Thalmann, Nadia Society for Computational Design and Engineering 2009 International Journal of CAD/CAM Vol.9 No.1

Shaping realistic hairstyles for digital characters is a difficult, long and tedious task. The lack of appropriate interaction metaphors enabling efficient and simple, yet accurate hair modeling further aggravates the situation. This paper presents 3D interaction metaphors for modeling virtual hair using haptic interfaces. We discuss user tasks, ergonomic aspects, as well as haptics-based styling and fine-tuning tools on an experimental prototype. In order to achieve faster haptic rates with respect to the hair simulation and obtain a transparent rendering, we adapt our simulation models to comply with the specific requirements of haptic hairstyling actions and decouple the simulation of the hair strand dynamics from the haptic rendering while relying on the same physiochemical hair constants. Besides the direct use of the discussed interaction metaphors in the 3D modeling area, the presented results have further application potential in hair modeling facilities for the entertainment industry and the cosmetic sciences.

양자 화학 데이터의 시각화

장윤,Ugo Varetto 한국컴퓨터그래픽스학회 2012 한국컴퓨터그래픽스학회 학술대회 Vol.2012 No.6