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Matsumura Nahomi,Li Xianqi,Uchikawa-Kitaya Eri,Li Ni,Dong Hongwei,Chen Kai,Yoshizawa Michiko,Kagami Hideaki 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.2
BACKGROUND: Although tooth transplantation is a desirable treatment option for congenital defects of permanent teeth in children, transplantation to a narrow alveolar ridge is not feasible. In this study, we investigated the possibility of bone tissue engineering simultaneously with tooth transplantation to enhance the width of the alveolar bone. METHODS: Bone marrow mononuclear cells or cortical bone-derived mesenchymal stromal cell spheroids were seeded onto atelocollagen sponge and transplanted with freshly extracted molars from mice of the same strain. New bone formation around the tooth root was evaluated using micro-computed tomography and histological analysis. Tooth alone, or tooth with scaffold but without cells, was also transplanted and served as controls. RESULTS: Micro-computed tomography showed new bone formation in the furcation area in all four groups. Remarkable bone formation outside the root was also observed in the cortical bone-derived mesenchymal stromal cell group, but was scarce in the other three groups. Histological analysis revealed that the space between the new bone and the root was filled with collagen fibers in all four groups, indicating that the periodontal ligament was maintained. CONCLUSION: This study demonstrates the potential of simultaneous alveolar bone expansion employing bone tissue engineering approach using cortical bone-derived mesenchymal stromal cell spheroids for tooth transplantation. The use of an orthotopic transplantation model may further clarify the feasibility and functional recovery of the transplanted tooth over a longer period.
A,Ueno,S,Kokubun,Y,Uchikawa 한국과학기술원 인간친화 복지 로봇 시스템 연구센터 2007 International Journal of Assistive Robotics and Me Vol.8 No.1
This paper presents a prototype real-time system that assesses the vigilance level of a subject and alerts the subject with sound stimulation when the assessed vigilance level is below a predetermined threshold. An acceleration property of saccadic eye movement, which is measured with a limbus eye tracker, is used as an index of the vigilance level. The algorithms for computing the index and for triggering sound stimulation according to the index value were implemented in a digital signal processor for realizing a real-time system. The developed system was evaluated through eye tracking tasks. The results indicated that the developed system stably assessed the vigilance level and stimulated the subject as designed when necessary. Although more precise and wide investigation is necessary to make a conclusion, we could confirm quantitatively that the system was able to arouse the subject by using sound stimulation. These results indicate a feasibility of the developed system not only for vigilance monitoring and subject stimulating, but also for exploring quantitatively effective conditions of stimulation to arouse the subject.