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Potential assessment of an innovative hybrid ventilator for building ventilation
Tzyy-hwang Shieh,Pei-Chi Chang,Che-ming Chiang,Chi-ming Lai 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.11
In this study, an innovative rooftop turbine ventilator powered by a hybrid of wind and photovoltaic energy, “Hybrid Ventilator” for short, was developed. The performance differences between Hybrid Ventilators and conventional ventilators were assessed through a series of experiments. Then, CFD (Computational Fluid Dynamics) simulations were applied to survey the building ventilation efficiency of this Hybrid Ventilator. The results show that, considering the ventilation quantity (rate), a Hybrid Ventilator provides approximately 4times the exhaust capacity of a conventional ventilator. All of the investigated space configurations that were examined via CFD simulations exhibited similar indoor airflow patterns and air velocity distributions (ventilation quality).
Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women
Chong, Eric Tzyy Jiann,Goh, Lucky Poh Wah,See, Edwin Un Hean,Chuah, Jitt Aun,Chua, Kek Heng,Lee, Ping-Chin Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2
Background: Breast cancer is the most common type of cancer affecting Malaysian women. Recent statistics revealed that the cumulative probability of breast cancer and related deaths in Malaysia is higher than in most of the countries of Southeast Asia. Single nucleotide polymorphisms (SNPs) in CYP2E1 (rs6413432 and rs3813867), STK15 (rs2273535 and rs1047972) and XRCC1 (rs1799782 and rs25487) have been associated with breast cancer risk in a meta-analysis but any link in Southeast Asia, including Malaysia, remained to be determined. Hence, we investigated the relationship between these SNPs and breast cancer risk among Malaysian women in the present case-control study. Materials and Methods: Genomic DNA was isolated from peripheral blood of 71 breast cancer patients and 260 healthy controls and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Our study showed that the c1/c2 genotype or subjects with at least one c2 allele in CYP2E1 rs3813867 SNP had significantly increased almost 1.8-fold higher breast cancer risk in Malaysian women overall. In addition, the variant Phe allele in STK15 rs2273535 SNP appeared to protect against breast cancer in Malaysian Chinese. No significance association was found between XRCC1 SNPs and breast cancer risk in the population. Conclusions: This study provides additional knowledge on CYP2E1, STK15 and XRCC1 SNP impact of risk of breast cancer, particularly in the Malaysian population. From our findings, we also recommend Malaysian women to perform breast cancer screening before 50 years of age.
김완희,Hae Ji Ahn,Tzyy-Jen Chiou,안지훈 한국분자세포생물학회 2011 Molecules and cells Vol.32 No.1
A moderate change in ambient temperature significantly affects plant physiology including flowering time. MiR399 and its target gene PHOSPHATE 2 (PHO2) are known to play a role in the maintenance of phosphate homeostasis. However, the regulation of flowering time by the miR399-PHO2 module has not been investigated. As we have previously identified miR399 as an ambient temperature-res-ponsive miRNA, we further investigated whether a change in expression of the miR399-PHO2 module affects flowering time in response to ambient temperature changes. Here, we showed that miR399b-overexpressing plants and a loss-of-function allele of PHO2 (pho2) exhibited an early flowering phenotype only at normal temperature (23C). Interestingly, their flowering time at lower temperature (16ºC) was similar to that of wild-type plants, suggesting that alteration in flowering time by miR399 and its target PHO2 was seen only at normal temperature (23C). Flowering time ratio (16C/23C) revealed that miR399b-overex-pressing plants and pho2 mutants showed increased sensitivity to ambient temperature changes. Expression analysis indicated that expression of TWIN SISTER OF FT (TSF) was increased in miR399b-overexpressing plants and pho2 mutants at 23C, suggesting that their early flo-wering phenotype is associated with TSF upregulation. Taken together, our results suggest that miR399, an am-bient temperature-responsive miRNA, plays a role in am-bient temperature-responsive flowering in Arabidopsis.
Seonki Lee,Huijuan Xu,Scott A. Rice,Tzyy Haur Chonga,오현석 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.94 No.-
Biofouling is recognized as one of the most problematic fouling types in reverse osmosis (RO) processesand lead to high energy requirements and operating costs. Over the past decade, many studies onmembrane bioreactor (MBR) systems for wastewater applications demonstrated that disrupting cell-cellcommunications among bacteria, called quorum quenching (QQ), is a promising approach to inhibitbiofouling of membranes. Here, we developed the QQ-column as a novel strategy to control biofouling inRO systems. The QQ-column was prepared by incorporating a recombinant bacterial QQ strain intohydrogel beads and embedding these beads inside a column. The QQ-column was installed upstream ofthe RO module to degrade N-acyl homoserine lactone, a quorum sensing (QS) signal, from the feed in alaboratory-scale RO system operating in total recycle mode. The QQ-column reduced the concentrationsof signal molecules by29% in an RO system and mitigated biofilm formation (38.6% reduction of cellnumber) on the membrane, consequently reducing the transmembrane pressure by 50.1%. These resultsdemonstrate that integrating QQ bacteria into columns is a practical method to control biofouling in ROsystems.
Evaluation of Heat Transfer in Acupuncture Needles: Convection and Conduction Approaches
Ya-Chien Chung,Chieh-Han John Tzou,Tzyy-Yih Yang 사단법인약침학회 2015 Journal of Acupuncture & Meridian Studies Vol.8 No.2
Originating in ancient China, acupuncture using needles has been developed for thousands of years and has received attention for its reported medical remedies, such as pain relief and chronic disease treatment. Heat transfer through the needles, which might have effects on the biomechanism of acupuncture, providing a stimulus and regulating homeostasis, has never been studied. This article analyzes the significance of heat transfer through needles via convection and conduction, approached by means of computational analysis. The needle is a cylindrical body, and an axis symmetrical steady-state heat-transfer model that viscosity and static pressure was not applied. This article evaluates heat transfer via acupuncture needles by using five metal materials: silver, copper, brass, iron, and stainless steel. A silver needle of the type extensively applied in acupuncture can dissipate more than seven times as much heat as a stainless steel needle of the same type. Heat transfer through such a needle is significant, compared to natural body-energy consumption over a range of ambient temperatures. The mechanism by which heat flows in or out of the body through the needles may be crucial in the remedial efficacy of acupuncture.
Goh, Lucky Poh Wah,Chong, Eric Tzyy Jiann,Chua, Kek Heng,Chuah, Jitt Aun,Lee, Ping-Chin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
CYP2E1 PstI polymorphism G-1259C (rs3813867) genotype distributions vary significantly among different populations and are associated with both diseases, like cancer, and adverse drug effects. To date, there have been limited genotype distributions and allele frequencies of this polymorphism reported in the three major indigenous ethnic groups (KadazanDusun, Bajau, and Rungus) in Sabah, also known as North Borneo. The aim of this study was to investigate the genotype distributions and allele frequencies of the CYP2E1 PstI polymorphism G-1259C in these three major indigenous peoples in Sabah. A total of 640 healthy individuals from the three dominant indigenous groups were recruited for this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) at G-1259C polymorphic site of CYP2E1 gene was performed using the Pst I restriction enzyme. Fragments were analyzed using agarose gel electrophoresis and confirmed by direct sequencing. Overall, the allele frequencies were 90.3% for c1 allele and 9.7% for c2 allele. The genotype frequencies for c1/c1, c1/c2 and c2/c2 were observed as 80.9%, 18.8%, and 0.3%, respectively. A highly statistical significant difference (p<0.001) was observed in the genotype distributions between indigenous groups in Sabah with all Asian and non-Asian populations. However, among these three indigenous groups, there was no statistical significant difference (p>0.001) in their genotype distributions. The three major indigenous ethnic groups in Sabah show unique genotype distributions when compared with other populations. This finding indicates the importance of establishing the genotype distributions of CYP2E1 PstI polymorphism in the indigenous populations.