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RNA Interference: a Promising Therapy for Gastric Cancer
Felipe, Aledson Vitor,Oliveira, Juliana de,Chang, Paula Yun Joo,Moraes, Andrea Aparecida de Fatima Souza,Silva, Tiago Donizetti da,Tucci-Viegas, Vanina Monique,Forones, Nora Manoukian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Gastric cancer (GC) remains a virtually incurable disease when metastatic and requires early screening tools for detection of early tumor stages. Therefore, finding effective strategies for prevention or recurrence of GC has become a major overall initiative. RNA-interference (RNAi) is an innovative technique that can significantly regulate the expression of oncogenes involved in gastric carcinogenesis, thus constituting a promising epigenetic approach to GC therapy. This review presents recent advances concerning the promising biomolecular mechanism of RNAi for GC treatment.