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      • Fast Discovery of Frequent Itemsets through Clustering and Decomposition

        Tsui-Ping Chang 한국산학기술학회 2012 SmartCR Vol.2 No.6

        In a previous paper, we proposed a technique called the top-down mining (TDM) algorithm to speed up the task of mining hybrid sequential patterns. TDM has a unique feature that examines database itemsets in a top-down manner using decomposition. This method, however, may incur a space problem during decomposition transactions from the database. In this paper, therefore, we propose a new algorithm called transaction decomposition with clustering (TDC) to alleviate the space problem associated with the decomposition method. We use TDC to derive frequent itemsets from a large database. The major feature of TDC is that it divides a database into several smaller projected databases such that each portion can be solved with the decomposition method independently. Since a large amount of information does not have to be stored in memory, the TDC method can efficiently mine frequent itemsets. We compare experimental results for the proposed method and existing algorithms. The results show that TDC can solve the space problem of TDM, and TDC outperforms its counterpart algorithms in many cases. Even when the data set is large or the user-specified minimum support is low, the TDC method still exhibits high performance in mining frequent itemsets. This makes the TDC method suitable for mining frequent itemsets in very large databases.

      • Harnessing Sphingosine-1-Phosphate Signaling and Nanotopographical Cues To Regulate Skeletal Muscle Maturation and Vascularization

        Tsui, Jonathan H.,Janebodin, Kajohnkiart,Ieronimakis, Nicholas,Yama, David M. P.,Yang, Hee Seok,Chavanachat, Rakchanok,Hays, Aislinn L.,Lee, Haeshin,Reyes, Morayma,Kim, Deok-Ho American Chemical Society 2017 ACS NANO Vol.11 No.12

        <P>Despite possessing substantial regenerative capacity, skeletal muscle can suffer from loss of function due to catastrophic traumatic injury or degenerative disease. In such cases, engineered tissue grafts hold the potential to restore function and improve patient quality of life. Requirements for successful integration of engineered tissue grafts with the host musculature include cell alignment that mimics host tissue architecture and directional functionality, as well as vascularization to ensure tissue survival. Here, we have developed biomimetic nanopatterned poly(lactic-<I>co</I>-glycolic acid) substrates conjugated with sphingosine-1-phosphate (S1P), a potent angiogenic and myogenic factor, to enhance myoblast and endothelial maturation. Primary muscle cells cultured on these functionalized S1P nanopatterned substrates developed a highly aligned and elongated morphology and exhibited higher expression levels of myosin heavy chain, in addition to genes characteristic of mature skeletal muscle. We also found that S1P enhanced angiogenic potential in these cultures, as evidenced by elevated expression of endothelial-related genes. Computational analyses of live-cell videos showed a significantly improved functionality of tissues cultured on S1P-functionalized nanopatterns as indicated by greater myotube contraction displacements and velocities. In summary, our study demonstrates that biomimetic nanotopography and S1P can be combined to synergistically regulate the maturation and vascularization of engineered skeletal muscles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2017/ancac3.2017.11.issue-12/acsnano.7b00186/production/images/medium/nn-2017-001868_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn7b00186'>ACS Electronic Supporting Info</A></P>

      • KCI등재

        The roles of ARID1A in gynecologic cancer

        Tsui-Lien Mao,Ie-Ming Shih 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.4

        One of the exciting findings in recent cancer genome studies is the discovery of somatic mutations in several chromatin remodeling genes. These studies not only illuminate the emerging roles of chromatin remodeling in the pathogenesis of human cancer but also provide molecular genetic basis of aberrant epigenomic regulation as one of the key mechanisms driving cancer development. This is because chromatin remodeling influences a variety of DNA activities such as replication, transcription, repair, methylation, and recombination. Among the mutated chromatin remodeling genes reported, ARID1A is frequently mutated in a variety of human cancers, especially in endometrium-related neoplasms including ovarian clear cell carcinoma, ovarian endometrioid carcinomas, and uterine endometrioid carcinomas, all of which arise from endometrial epithelium. This review will summarize the recent advances in studying the roles of ARID1A mutations in gynecologic cancers with special emphasis on how this new knowledge will further extend our understanding of the pathogenesis of endometrium-related carcinomas.

      • SCOPUSKCI등재

        WELFARE EFFECTS AND OPTIMAL INCENTIVE PACKAGE OF EXPORT PROCESSING ZONES

        TSUI, KAI YUEN 한국국제경제학회 1993 International Economic Journal Vol.7 No.2

        This paper introduces bargaining as an organizing framework to study the welfare effects of export processing zones in a distortion-ridden open economy with Harris-Todaro type unemployment. General guidelines for the design of optimal incentive package are explored. [F21]

      • KCI등재

        Examining Customers’ Intention of Continued Use and Cross-Buying on Internet-Only Banks

        Annie Tsui,이경영,Paola Gonzalez,Bo Yu 한국경영정보학회 2024 Asia Pacific Journal of Information Systems Vol.34 No.1

        Internet-only banks (IOB) refer to financial institutions which provide services entirely through online digital platforms without physical branches. Although IOBs have been around for over 26 years, there is still room for investigating what factors motivate customers to use them continuously and extensively. Therefore, this study aims to examine what factors lead to customers’ intention of continued use and cross-buying on IOBs by extending the Post-Acceptance Model of IS Continuance (PAMISC). The result shows that perceived economic benefit and ongoing trust have significant relationships with the intention of continued use and that ongoing trust has significant direct and mediating (via intention of continued use) relationships with the intention of cross-buying. Also, personal innovativeness positively moderates the relationship between ongoing trust and the intention of cross-buying. This study sheds light on the literature on branchless financial services and PAMISC. IOB practitioners should revisit the effectiveness of customers’ economic benefits to establish ongoing trust with customers.

      • KCI등재
      • KCI등재
      • State Capacity in City Planning: The Reconstruction of Nanjing, 1927-1937

        Carmen Tsui 고려대학교 민족문화연구원 2011 Cross-Currents Vol.- No.1

        After reunifying China in 1927, the Nationalist government proposed a comprehensive planning proposal, the Capital Plan (shoudu jihua), to reconstruct the war-torn city of Nanjing into a modern capital, despite the fact that the infant republic was still threatened by internal strife and external aggression. This article discusses the complex politics involved in the reconstruction of Nanjing from 1927 to 1937, illustrating the way in which the Nationalist state tried to transform China’s urban development. It focuses on why unified planning ideas could not be generated during the planning process, and why these ideas did not turn fully into practice during the implementation process. By studying the aborted effort in planning Nanjing, knowing in what particular dimensions the state excelled and in what other dimensions things went wrong, this article analyzes the unevenness of state capacity in Republican China.

      • KCI등재

        중공군의 한국전쟁 참전(ⅩⅤ)

        David Tsui(데이빗 쑤이) 한국전략문제연구소 2010 전략연구 Vol.- No.49

        1951년 중순 CPVA의 제 5차 전역의 실패는 전쟁의 종결을 위한 휴전협상 개최에 대한 북경의 태도 변화에 하나의 분수령이 되었음이 증명되었다. 초기 4개의 전역은 CPVA로 하여금 UN군에 대항해 공격 및 방어 작전 모두를 수행할 수 있게 했다. 이 전역들은 북경의 군사적 자신감을 북돋아주었다고 할 수 있다. 이 단계에서 모택동은 CPVA가 UN군을 전쟁의 패자 혹은 최소한 열등한 존재로서 협상 테이블로 부를수 있을 것이라고 기대했다. 결과적으로 북경은 다음과 같은 휴전협상의 엄격한 전제조건을 주장했다. (1) 한반도에서의 외국군 철수 (2) 한반도 인민들의 민족 자결권(3) 대만에서의 미군철수 (4) 중국의 UN가입. 하지만 제 5차 전역 후 북경은 CPVA의 기술적 수준이 근본적으로 향상되지 않는 한 이러한 기대들이 불가능하다는 것을 깨닫게 되었다. 따라서 CPVA는 위의 모든 비현실적인 전제조건을 포기하면서 UN군과 대충 동등한 위상으로 휴전협상에 임해야만 했다. 원래 스탈린이 먼저 생각해내고 제시되었지만, 성공적인 제 3차 전역의 승리 직후에 공산측이 서울과 남한영토 일부를 미군의 대만철수와 중국의 UN가입 및 대일 공동 평화조약과 교환한다는 목적을 가지고 UN군과 휴전협상을 해야 한다는 Peng의 제안이 모택동과 UN군에게 받아들여졌다면 이것은 중국에 있어 최대의 이득이 되었을 것이다. 이런 제안을 거절해 현재까지 대만문제가 미해결됨으로써 모택동은 자신의 군사 경력에 최대 오점을 남긴 것으로 평가될 수 있다. 제 1장에서 김일성의 한반도 전체의 “해방”에 대한 모택동의 태도가 스탈린 보다는 더 긍정적이었다고 저자가 주장한바 있는데, 초기 휴전협상에 대한 스탈린의 태도가 모택동 보다는 덜 완고했다는 것은 흥미롭다.

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