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When outbound mobility programs and service learning align in pre-service teacher education
Anne Power,Son Truong,Tonia Gray,Greg Downey,Tim Hall,Benjamin Jones 서울대학교 교육연구소 2017 Asia Pacific Education Review Vol.18 No.3
This project sought to investigate the learning that comes about from the intersection of outbound mobility experience programs (OMEs) with service learning in pre-service teacher education settings. The aim of the program of international service learning in the case study was to encourage pre-service teachers to rethink potentially ethnocentric assumptions. The guiding research question was, ‘What outcomes ensue from the combination of OMEs and service learning for pre-service teachers?’ The focus of the paper was on OMEs that took place in China and Malaysia. Findings included that the combined program aided development of global mindedness, learning by being there, teacher experience in a new context and the development of a professional identity in the participating students.
Jung, Kijung,Kim, Kunsoon,Sung, Jong-Chan,Ahmed, Tonia S.,Hong, Soon Hyeok,Grubbs, Robert H.,Choi, Tae-Lim American Chemical Society 2018 Macromolecules Vol.51 No.12
<P>Ru-based metathesis catalysts employed in cyclopolymerization (CP) of 1,6-heptadiyne derivatives have promoted regioselective α-addition to alkynes, forming various conjugated polyenes containing exclusively five-membered repeat units. Recently, we discovered that a new chelated Ru catalyst could promote regioselective β-addition to produce analogous polyenes containing six-membered rings with moderate to good β-selectivity. Since then, we have focused our research on pursuing more active and β-selective regiocontrol to produce conjugated polymers with excellent β-selectivity, with a much broader range of monomers. Herein, we demonstrate highly β-selective CP by combining a new dithiolate-chelated Ru-based catalyst with weakly coordinating pyridine additives, which significantly enhance the conversion and β-selectivity. An in-depth mechanistic investigation by <SUP>1</SUP>H NMR revealed a prominent role for the additives, which improve the stability of the propagating carbene.</P> [FIG OMISSION]</BR>
Xudong Di,Danica M.K. Andrews,Charles J. Tucker,Linda Yu,Alicia B. Moore,Xiaolin Zheng,Lysandra Castro,Tonia Hermon,Hang Xiao,Darlene Dixon 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.4
Previously, we found that high doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation. In this study, using microarray analysis and Ingenuity Pathways AnalysisTM, we identified genes (up- or down-regulated, ≥ 1.5 fold, P ≤ 0.001),functions and signaling pathways that were altered following treatment with an inhibitory concentration of genistein (50 μg/ml) in UtLM cells. Downregulation of TGF-β signaling pathway genes, activin A, activin B,Smad3, TGF-β2 and genes related to cell cycle regulation,with the exception of the upregulation of the CDK inhibitor P15, were identified and validated by real-time RT-PCR studies. Western blot analysis further demonstrated decreased protein expression of activin A and Smad3 in genistein-treated UtLM cells. Moreover, we found that activin A stimulated the growth of UtLM cells, and the inhibitory effect of genistein was partially abrogated in the presence of activin A. Overexpression of activin A and Smad3 were found in tissue samples of leiomyoma compared to matched myometrium, supporting the contribution of activin A and Smad3 in promoting the growth of UtLM cells. Taken together, these results suggest that downregulation of activin A and Smad3, both members of the TGF-β pathway, may offer a mechanistic explanation for the inhibitory effect of a high-dose of genistein on UtLM cells, and might be potential therapeutic targets for treatment of clinical cases of uterine leiomyomas.