Study on an emulsion-type blockage removal agent for heavy oil recovery enhanced by polymer

Tongyu Zhu,Hongbin Yang,Haizhuang Jiang,Xin Kang,Menglan Li,Min Zhang,Wanli Kang,Bauyrzhan Sarsenbekuly,Saule Aidarova,Maratbek Gabdullin 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-

In polymerflooding process, the poor solubility of polymer and the wrap of incompletely dissolvedpolymer particles with heavy oil lead to the generation of complicated blockage, which seriously affectsthe normal production of wells. Therefore, how to fabricate an effective blockage removal agent isparticularly important. Based on the blockage from Bohai Offshore Oilfield in China, a blockage removalagent composed of (0.5 wt% potassium persulfate + kerosene (the ratio of kerosene: blockage is 3:5)+0.3 wt% OP-10, the oil-water ratio is 1:9) was developed. The removal effect and mechanism werecharacterized by weight loss method and core test. Moreover, the emulsification property of the removalagent was also evaluated by microscopic appearance. The results showed that the blockage removal agentcan be formulated as an O/W emulsion and had good stability for more than 72 h. Core test showed thatthe permeability had a significant improvement after injection of removal agent. The emulsion-typeremoval agent can demulsify after contact with the blockage, then the oil-soluble detergent as internalphase in emulsion can be released which contributes to the wash off of heavy oil. Accompanied with thepolymer degradation by the oxidant, this agent realized the effective dissolution and removal of blockage.

Combinatorial nanococktails via selfassembling lipid prodrugs for synergistically overcoming drug resistance and effective cancer therapy

Tongyu Li,Weiwei Shi,Jie Yao,Jingyun Hu,Qiong Sun,Jing Meng,Jian Wan,Haihan Song,Hangxiang Wang 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1

Background: Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has not been reported and remains challenging. Methods: Synthesized chrysotile nanotubes (SCNTs) with a relatively uniform length (~ 200 nm) have been designed to deliver an siRNA against the oncogenic circPRMT5 (si-circPRMT5) inhibit circPRMT5. In addition, the antitumor effects and safety evaluation of SCNTs/si-circPRMT5 was assessed with a series of in vitro and in vivo assays. Results: The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5’s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of circPRMT5. In vitro, SCNTs encapsulating si-circPRMT5 could inhibit bladder cancer cell growth and progression. In vivo, SCNTs/si-circPRMT5 inhibited growth and metastasis in three bladder tumor models (a subcutaneous model, a tail vein injection lung metastatic model, and an in situ model) without obvious toxicities. Mechanistic study showed that SCNTs/sicircPRMT5 regulated the miR-30c/SNAIL1/E-cadherin axis, inhibiting bladder cancer growth and progression. Conclusion: The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer. Keywords: Synthesized chrysotile nanomaterials, Gene therapy, Targeted delivery, CircPRMT5, SiRNA, Bladder cancer

RAR-Related Orphan Receptor: An Accelerated Preeclampsia Progression by Activating the JAK/STAT3 Pathway

Ying Yu,Tongyu Zhu 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.6

Purpose: To investigate the effect and underlying mechanism of RAR related orphan receptor A (RORA) on preeclampsia (PE). Materials and Methods: Differentially expressed genes (DEGs) in four datasets were obtained by using the Venn diagram method. RORA mRNA and protein expressions were detected by qRT-PCR, western blot, and immunohistochemistry. HTR-8/SVneocell viability, proliferation, invasion, migration, and angiogenesis were detected by CCK-8 assay, EdU assay, Transwell, woundhealing assay, and tube formation assay, respectively. The concentration of Ang-1 in cells was assessed using available ELISA kit. Epithelial-mesenchymal transition, proliferation, and angiogenesis-related proteins were detected by western blot. GSEA analysiswere performed for common DEGs, and the expression of enriched pathway-related proteins was also detected. Results: The expression of RORA was increased in PE tissue and HTR-8/SVneo cells. Silencing RORA could promote the migration,invasion, epithelial-mesenchymal transition, proliferation, and angiogenesis of hypoxia-treated HTR-8/SVneo cells. Mechanistically,RORA contributed to the deterioration of PE by activating the JAK2/STAT3 signaling pathway to promote cell proliferation,migration, invasion, and angiogenesis. Conclusion: RORA was up-regulated in PE and affected HTR-8/SVneo cell proliferation, invasion, migration, apoptosis, and angiogenesisvia the JAK2/STAT3 signaling pathway. This provided a novel strategy for the prevention and treatment of PE.

High frequency pulse injected double stage filtering method for linear permanent magnet motor position error compensation considering parameter asymmetry

Yan, Jianhu,Song, Tongyue,Chi, Song,Ying, Zhanfeng The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.9

Due to machining errors and the effect of the longitudinal end of a stator, linear permanent magnet motors (LPMMs) produce asymmetric three-phase winding resistance and inductance. After a Park transformation of the asymmetric three-phase stator inductance, the dq axis inductance is not constant, and the dq axis is coupled. This leads to errors in estimating the motor position by the traditional pulse injection method. In this paper, the position estimation error caused by parameter asymmetry is analyzed to discuss the influence of LPMM asymmetric three-phase winding parameters on high frequency pulse injection sensorless method error. Moreover, a double stage filtering method is used to realize error compensation. On this basis, a simulation model was built by MATLAB/Simulink and experiments were carried out on a LPMM prototype under no-load conditions. The simulation and experimental results verify that the double stage filtering method can improve the position estimated accuracy and dynamic performance under sensorless control.

Bidirectional‑friendly rectifier control strategy for advanced traction power supply system under unbalanced supply

Li Zeng,Pengcheng Han,Tongyue Huang,Xiaoqiong He 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.5

A bidirectional-friendly control strategy of three-phase NPC rectifier under unbalanced voltage for advanced traction power supply system (ATPSS) is proposed in this study. Negative-sequence current and DC voltage ripple are restrained effectively with very low total harmonic distortions (THDs) on the basis of predictive current control theory. First, power balance equation containing only positive-sequence voltage of the three-phase grid voltage is derived, and the secondary fluctuation of instantaneous active and reactive powers on the grid side is analyzed and calculated. Second, expression of the DC-side voltage fluctuation is deduced to fix the calculation of Pref for the optimization of the control system. Third, command current that can achieve bidirectional-friendly control is calculated according to the power expression and the reference voltage value is obtained on the basis of the predictive current control principle. Finally, simulations and experimental results verify the correctness of the theoretical analysis and the effectiveness of the proposed strategy.

Shear resistance performance of low elastic polymer microspheres used for conformance control treatment

Hongbin Yang,Shuo Shao,Tongyu Zhu,Chaocheng Zhao,Shuren Liu,Bobo Zhou,Xiaoyu Hou,Yang Zhang,Wanli Kang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.79 No.-

Low elastic polymer microsphere (L-EPM) has been proposed as a functional polymer microsphere theseyears. L-EMP has the excellent deformation ability in the porous medium due to the low storage modulus. Herein, one kind of L-EPM with storage modulus (G0) of 23.6 Pa was prepared by inverse suspensionpolymerization. The shear resistance of L-EPM was researched by using coreflooding experiment andhigh shear rate emulsifier. The conformance control behavior of L-EPM was investigated by using doubleparallel sandpackflooding experiment. The results showed that L-EPM was a kind of swollen particle gelwith three-dimensional net structure and contained amide, carboxyl, and sulfonate groups. Themechanism of water swelling property was mainly due to the formation of hydrogen bonds, hydrolysis ofhydrophilic groups and the diffusion caused by osmotic pressure difference. Compared with high elasticpolymer microspheres (H-EPM) and low elastic preformed particle gel (L-PPG), L-EPM had better shearresistance in the porous medium and the well casing perforation. In addition, the critical shear points ofL-EPM was proposed in this work. Due to the better shear resistance and deformation ability, theconformance control behavior of L-EPM showed that L-EPM was a promising conformance control agentin the heterogeneous reservoirs.

An Integrated Nomogram Combining Clinical Factors and Microtubule-Associated Protein 1 Light Chain 3B Expression to Predict Postoperative Prognosis in Patients with Intrahepatic Cholangiocarcinoma

Liang Chen,Hongyuan Fu,Tongyu Lu,Jianye Cai,Wei Liu,Jia Yao,Jinliang Liang,Hui Zhao,Jiebin Zhang,Jun Zheng,Yingcai Zhang,Yang Yang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

Purpose Microtubule-associated protein 1 light chain 3B (LC3B) serves as a key component of autophagy, which is associated with the progression of carcinoma. Yet, it is still unclear whether LC3B is also an independent risk factor for intrahepatic cholangiocarcinoma (ICC). We aim to explore the predictive value of LC3B on prognosis of ICC, and to establish a novel and available nomogram to predict relapse-free survival (RFS) and overall survival (OS) for these patients after curative-intent hepatectomy. Materials and Methods From August 2004 to March 2017, 105 ICC patients were eligibly enrolled in the Third Affiliated Hospital of Sun Yat-sen University. Preoperative clinical information of enrolled patients was collected. Expression LC3B in the ICC specimen was detected by immunohistochemistry. Results The 5-year RFS and OS in this cohort were 15.7% and 29.6%, respectively. On multivariate Cox regression analysis, independent risk factors for 5-year OS were cancer antigen 125, microvascular invasion, LC3B expression and lymph node metastasis. Except for the above 4 factors, neutrophil/lymphocyte ratio and tumor differentiation were independent factors for 5-year RFS. The area under the curve of nomograms for OS and RFS were 0.820 and 0.747, respectively. Conclusion The nomograms based on LC3B can be considered as effective models to predict postoperative survival for ICC patients.

ADAPTIVE NOISE CANCELLATION APPLIED IN HYDRODYNAMIC FIELD

Yuanheng Liu,Ning Ma,Tongyu Li 한국소음진동공학회 1994 한국소음진동공학회 국제학술대회논문집 Vol.1994 No.4

Application of PSO Algorithm Based on Improved Accelerating Convergence in Task Scheduling of Cloud Computing Environment

Zhulin Li,Cuirong Wang,Haiyan Lv,Tongyu Xu 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.9

Hadoop uses a reliable, efficient and scalable way to process data. It provides a good solution for dealing with big data. The task scheduler is the core component of Hadoop, and it is responsible for the managing and allocating the cluster resources. Therefore, scheduling algorithm directly affects the overall performance of Hadoop platform and utilization of cluster resource. Based on this, the improved accelerate particle swarm algorithm (IAPSO) is introduced to the cloud environment, and to solve the cloud task scheduling problem in this article. When we use particle swarm algorithm for task scheduling, the tasks are considered as particles, the resource pool is seen as the search space, and the process of finding the optimal solution is considered as a process of task scheduling. If all the sub tasks find the appropriate resources, then stop the iteration and allocate sub asks to the resource nodes. Finally, we simulate the experiment by using CloudSim software. When a single type of task is committed, our algorithm and the other three algorithms can also be used to complete the task scheduling process, and our algorithm is more efficient. But in practice, the cloud computing environment is facing multiuser, and the types of tasks are also varied. With the increase in the number of tasks, the advantage of the other three algorithms decreases gradually, but algorithm in this paper has been exhibited higher efficiency. In addition, with the increase of the number of nodes, task completed time of the algorithm in this paper is significantly less than the other three algorithms, and it has a steady downward trend. Therefore, IAPSO algorithm which is proposed in this paper is applied to solve task scheduling problem in the cloud environment, and it can effectively improve the efficiency of task scheduling.

Optimization of a crossbar parallel machine tool based on workspace and dexterity

Fang Xifeng,Zhang Sichong,Xu Qinhuan,Wang Tongyue,Liu Yuanwei,Chen Xiaogang 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.8

Increasing workspace and improving dexterity are important tasks for the design of parallel machine tools. The workspace of a crossbarparallel machine tool with constraints is obtained by using a 3D search method based on inverse kinematics. The new Jacobian matrixof the machine is also derived by using the natural coordinate method. Dexterity distribution of the machine tool is obtained on the basisof the workspace and the new Jacobian matrix. Influences of the structural parameters on the workspace volume index (WVI) and globaldexterity index (GDI) are analyzed. Structural optimization is conducted by treating the WVI and GDI as the global optimization goals. Unlike the initial data, the optimized results increased by 0.43 and 0.34 times.