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Chemokine and Chemokine Receptor Polymorphisms in Bipolar Disorder
Damla Tokac,Erdem Tuzun,Vuslat Yılmaz,Elif Sinem Bireller,Bedia Cakmakoglu,Cem Ismail Kucukali 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.5
ObjectiveaaBipolar disorder (BD) is a debilitating psychiatric disease with unknown etiology. Recent studies have shown inflammation as a potential contributing factor of BD pathogenesis. However, potential associations between chemokine and chemokine receptor polymorphisms and BD have been fundamentally understudied. To identify participation of chemokines in BD pathogenesis, we examined genetic variants of several chemokine and chemokine receptor genes. MethodsaaThe study population comprised 200 patients with BD and 195 age- and sex-matched healthy controls. Genotyping of monocyte chemotactic protein 1 (MCP-1) A2518G, CCR2 V64I, CCR5 Δ32, CCR5 A55029G, stromal cell-derived factor 1 (SDF-1) 3’A, and CXCR4 C138T polymorphisms was performed using polymerase chain reaction and restriction enzyme digestion. ResultsaaWe found that CCR5-Δ32 II and CXCR4-C138T C+ genotype frequencies contributed to an increased risk for BD. However, no statistical significance could be obtained with these genotypes after Bonferroni correction. A significant asssociation was only found with MCP-1 GG and G+ genotypes, which were markedly more prevalent in patients with BD and these genotypes seemed to significantly increase the risk for BD even after Bonferroni correction. ConclusionaaOur findings indicate an association between genetic variants of certain chemokine and chemokine receptor (especially MCP-1) genes and BD. The exact mechanisms by which these variants contribute to BD pathogenesis and their clinical implications need to be further investigated.
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Amy Freeman,남지원,Umit Tokac 한국행정학회 2020 International Review of Public Administration Vol.25 No.2
This study seeks to determine if for-profit healthcare organizations are more technically efficient than nonprofit organizations. We attempted to answer two questions: Does the technical efficiency of hospitals and nursing homes vary depending on ownership type? If so, how does time moderate the relationship between ownership and technical efficiency? Our findings do not show that for-profit healthcare providers are universally more technically efficient than nonprofit healthcare facilities. However, for-profit nursing homes are more technically efficient than nonprofit facilities, while there was no difference between nonprofits and forprofits in hospitals. An examination of healthcare facilities reveals that nonprofit institutions have only recently become efficient, while for-profit organizations were more efficient in the past. In conclusion, institutional changes in the healthcare delivery system of the US developed differently, depending on organization’s ownership and facility types. Theoretical and practical considerations were recommended as a policy tool in healthcare practices in terms of market and population for technical efficiency.
KCI
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