http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Tilson (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm
David C. Paik,Chenzhong Fu,Jahar Bhattacharya,M. David Tilson 생화학분자생물학회 2004 Experimental and molecular medicine Vol.36 No.6
Pathogenesis of the abdominal aortic aneurysm has been atributed to neovascularization of the aortic wall. However, it is not clear whether angiogenesis persists in the aneurysm. In sec-tions of aneurysms, we determined the imuno-histochemical distributions of the αvβ3 integrin, tenascin and endothelial nitric oxide synthase (eNOS), which are markers respectively, of an-giogenesis, matrix remodeling and vasoregula-tory function. In addition, we used reverse trans-cription folowed by in situ PCR, to determine the distribution of αv mRNA. Al aneurysm spec-imens exhibited extensive increases of wal vas-cularization as compared with the control aortic wall, and showed the presence of perivascular inflamatory exudates containing macrophages and lymphocytes. The neovascularization con-sisted of thick-waled vessels in the media and majority of vessels stained positively for the αvβ3 antigen and eNOS. Tenascin was deposited as bands that circumscribed thick-waled ves-sels. The distribution of av mRNA was extensive and was positive even in those vessels that failed to stain for the αvβ3 protein. No staining was evident in control aortas for the αvβ3 anti-gen, tenascin or αv mRNA. The upregulation of αv αvβ3 integrin in blod vessels surounded by a matrix expresing tenascin, indicates that angiogenesis is an ongoing pro-cess in the mature aortic aneurysm.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
