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Expression of proline-rich protein 15 in breast cancer and its effect on cell biological function
Jiao Tian,Yingzi Zhang,Chi Qu,Han Li,Shengchun Liu 한국고분자학회 2023 Macromolecular Research Vol.31 No.12
PRR15, a member of the proline-rich protein family, has been linked to a better prognosis in breast cancer patients and is highly expressed in a variety of cancer tissues. However, further research must be done on its biological role in breast cancer and its expression. The purpose of this work is to investigate the role of PRR15 in the proliferation, migration, and apoptosis of breast cancer cells as well as to confirm the differential expression of PRR15 in various subtypes of breast cancer tissues and cells. To analyse the differential expression of PRR15 in paracancerous tissues and various types of breast cancer tissues, GEPIA, Kaplan–Meier plotter, GEO, TCGA, and other bioinformatics websites and public databases were used. PRR15 expression in breast cancer tissue was significantly higher than that in normal breast tissue, and PRR15 expression in ER + breast cancer was significantly higher than that in ER- breast cancer. The results were confirmed by RT-PCR, Western Using molecular cloning, plasmids were created to produce cells that over express PRR15. Experiments on how cells behave showed that PRR15 overexpression had no impact on the growth, migration, or death of ER+ and ER− breast cancer cells when compared to control cells. Furthermore, the biological behavior of ER + breast cancer cells was unaffected by PRR15 knockdown.
The Software Trustworthiness Evaluation Model Based on Subjective Logic
Jiao Hongqiang,Tian Junfeng 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.1
In recent years, the trustworthiness of the software has become the focus of software quality. The software trustworthiness analysis and measurement has become a hot issue. Because of the great influence of software environment dynamic openness and uncertainty to the trustworthiness of the software, this paper attempts to examine the changes of software running environment, consider the impact on the software trustworthiness, and build the software trustworthiness evaluation (STE) model with subjective logic. The model can be real-time control the software running state and evaluate the software trustworthiness dynamically. In addition, on the setting of weight aspect, a subjective group preference weight setting algorithm is designed. Simulation results show that the model is reasonable and effective can be more accurate to evaluate the software trustworthiness.
교천장(Jiao Tian Zhang),윤정욱(Jung-wook Yoon) 한국레저사이언스학회 2023 한국레저사이언스학회지 Vol.14 No.1
본 연구는 올바른 중국의 엘리트 스포츠 문화 조성 및 중국 스포츠의 공정성에 도움을 줄 수 있는 기초적인 자료를제공하고, 중국 엘리트 수영지도자의 비윤리적인 문제점을 파악하여, 중국 엘리트 수영지도자들의 올바른 윤리의식확립과, 이를 개선하고 예방할 수 있는 방안을 제시하는데 이 연구의 목적이 있다. 연구방법은 질적 연구방법으로연구 참여자인 중국 엘리트 수영지도자 8명을 대상으로 심층면담을 진행하여 다음과 같은 결론을 얻을 수 있었다. 첫째, 중국 엘리트 수영지도자의 비윤리적 행위의 종류로는 도핑, 폭력, 승부조작으로 도출되었다. 둘째, 중국 엘리트수영지도자의 비윤리적 행위의 원인으로는 부정청탁 및 금품수수, 무사유, 승리지상주의로 도출되었다. 셋째, 중국엘리트 수영지도자의 스포츠 윤리교육에 대한 인식으로는 스포츠 윤리교육의 필요성, 수영 지도자에게 필요한 덕목, 스포츠윤리 지도자 교육으로 도출되었으며 스포츠 윤리교육은 반드시 필요하며, 성인기 보다는 아동기 때부터 스포츠윤리교육을 실시하는 것이 바람직하다고 하였다. This study aims to provide the baseline data that can help create the right Chinese elite sports culture and fairness in Chinese sports and understand unethical issues in Chinese elite swimming coaches to establish the right sense of ethics in Chinese elite swimming coaches and improve the problems and present measures for preventing them. As for research method, in-depth interviews were conducted with study participants, eight Chinese elite swimming coaches in a qualitative research method to draw the conclusions as follows. First, the types of unethical behavior of Chinese elite swimming coaches were identified as doping, violence, and match-fixing. Second, the causes of unethical behavior among Chinese elite swim coaches were identified as bribery and corruption, no-cause, and winner-take-all. Third, the perceptions of Chinese elite swim coaches on sports ethics education were identified as the necessity of sports ethics education, virtues required of swim coaches, and sports ethics leader education, and it was suggested that sports ethics education is essential and that it is desirable to implement sports ethics education from childhood rather than adulthood.
Brain-based Correlations Between Psychological Factors and Functional Dyspepsia
( Jiao Fen Nan ),( Ji Xin Liu ),( Jun Ya Mu ),( Wang Huan Dun ),( Ming Zhang ),( Qiyong Gong ),( Wei Qin ),( Jie Tian ),( Fanrong Liang ),( Fang Zeng ) 대한소화기기능성질환·운동학회 2015 Journal of Neurogastroenterology and Motility (JNM Vol.21 No.1
Background/Aims Increasing evidence shows involvement of psychological disorders in functional dyspepsia (FD), but how psychological factors exert their influences upon FD remains largely unclear. The purpose of the present study was to explore the brain-based correlations of psychological factors and FD. Methods Based on Fluorine-18-deoxyglucose positron emission tomography-computed tomography, the altered cerebral glycometabolism was investigated in 40 FD patients compared with 20 healthy controls during resting state using statistical parametric mapping software. Results FD patients exhibited increased glucose metabolism in multiple regions relative to controls (P < 0.001, family-wise error corrected). After controlling for the dyspeptic symptoms, increased aberrations persisted within the insula, anterior cingulate cortex (ACC), middle cingulate cortex (MCC) and middle frontal cortex (midFC), which was related to anxiety and depression score. Interestingly, FD patients without anxiety/depression symptoms also showed increased glycometabolism within the insula, ACC, MCC and midFC. Moreover, FD patients with anxiety/depression symptoms exhibited more significant hypermetabolism within the above 4 sites compared with patients without anxiety/depression symptoms.Conclusions Our results suggested that the altered cerebral glycometabolism may be in a vicious cycle of psychological vulnerabilities and increased gastrointestinal symptoms.
Dynamic Cloud Resource Reservation Model Based on Trust
( Jiao-hong Qiang ),( Ding-wan Ning ),( Tian-jun Feng ),( Li-wei Ping ) 한국정보처리학회 2018 Journal of information processing systems Vol.14 No.2
Aiming at the problem of service reliability in resource reservation in cloud computing environments, a model of dynamic cloud resource reservation based on trust is proposed. A domain-specific cloud management architecture is designed in which resources are divided into different management domains according to the types of service for easier management. A dynamic resource reservation mechanism (DRRM) is used to test users’ reservation requests and reserve resources for users. According to user preference, several resources are chosen to be candidate resources by fuzzy cluster analysis. The fuzzy evaluation method and a two-way trust evaluation mechanism are adopted to improve the availability and credibility of the model. An analysis and simulation experiments show that this model can increase the flexibility of resource reservation and improve user satisfaction.
DTN Routing with Back-Pressure based Replica Distribution
Jiao, Zhenzhen,Tian, Rui,Zhang, Baoxian,Li, Cheng The Korea Institute of Information and Commucation 2014 Journal of communications and networks Vol.16 No.4
Replication routing can greatly improve the data delivery performance by enabling multiple replicas of the same packet to be transmitted towards its destination simultaneously. It has been studied extensively recently and is now a widely accepted routing paradigm in delay tolerant networks (DTNs). However, in this field, the issue of how to maximize the utilization efficiency of limited replication quota in a resource-saving manner and therefore making replication routing to be more efficient in networks with limited resources has not received enough attention. In this paper, we propose a DTN routing protocol with back-pressure based replica distribution. Our protocol models the replica distribution problem from a resource allocation perspective and it utilizes the idea of back-pressure algorithm, which can be used for providing efficient network resource allocation for replication quota assignment among encountered nodes. Simulation results demonstrate that the proposed protocol significantly outperforms existing replication routing protocols in terms of packet delay and delivery ratio.
Improved Dynamic Subjective Logic Model with Evidence Driven
( Jiao Hong Qiang ),( Wang Xin Xin ),( Tian Jun Feng ) 한국정보처리학회 2015 Journal of information processing systems Vol.11 No.4
In JØsang’s subjective logic, the fusion operator is not able to fuse three or more opinions at a time and it cannot consider the effect of time factors on fusion. Also, the base rate (a) and non-informative prior weight (C) could not change dynamically. In this paper, we propose an Improved Subjective Logic Model with Evidence Driven (ISLM-ED) that expands and enriches the subjective logic theory. It includes the multi-agent unified fusion operator and the dynamic function for the base rate (a) and the non-informative prior weight (C) through the changes in evidence. The multi-agent unified fusion operator not only meets the commutative and associative law but is also consistent with the researchers’s cognitive rules. A strict mathematical proof was given by this paper. Finally, through the simulation experiments, the results show that the ISLM-ED is more reasonable and effective and that it can be better adapted to the changing environment.