N-Acetyltransferase 2 Gene Polymorphisms are Associated with Susceptibility to Cancer: a Meta-analysis

Tian, Fang-Shuo,Shen, Li,Ren, Yang-Wu,Zhang, Yue,Yin, Zhi-Hua,Zhou, Bao-Sen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

N-acetyltransferase 2 (NAT2) is a polymorphic enzyme that plays an important role in the metabolism of various potential carcinogens. In recent years, a number of studies have been carried out to investigate the relationship between the rs1799930 and rs1799931 polymorphism in NAT2 and cancer risk in multiple populations for different types of cancer. However, the results were not consistent. Therefore, we performed a meta-analysis to further explore the relationship between NAT2 polymorphism and the risk of cancer. A total of 21 studies involving 15, 450 subjects for rs1799930 and 13, 011 subjects for rs1799931 were included in this meta-analysis. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess strength of associations. We also evaluated the publication bias and performed a sensitivity analysis. Overall, our results showed an apparent significant association between the NAT2 rs1799930 polymorphism and cancer susceptibility in Asians (GA vs. GG: OR=1.22, 95% CI=1.03-1.45; dominant model: OR=1.22, 95% CI=1.03-1.43) and population-based controls (GA vs. GG: OR=1.10, 95% CI=1.01-1.19; dominant model: OR=1.09, 95% CI=1.01-1.18). In contrast, a significant association was observed between the NAT2 rs1799931 G>A polymorphism and decreased cancer susceptibility in overall meta-analysis (AA vs. GG: OR=0.55, 95% CI=0.33-0.93; GA vs. GG: OR=1.00, 95% CI=0.88-1.14; dominant model: OR=0.97, 95% CI=0.86-1.10; recessive model: OR=0.56, 95% CI=0.34-0.94) and the Asian group (AA vs. GG: OR=0.50, 95% CI=0.26-0.94; recessive model, OR=0.50, 95% CI=0.27-0.94). We found that the NAT2 rs1799930 may be a risk factor, while the NAT2 rs1799931 polymorphism is associated with a decreased risk of cancer and is likely a protective factor against cancer development.

P3H4 promotes renal cell carcinoma progression and suppresses antitumor immunity via regulating GDF15-MMP9-PD-L1 axis

Tian, Shuo,Huang, Yan,Lai, Dong,Wang, Hanfeng,Du, Songliang,Shen, Donglai,Chen, Weihao,Xuan, Yundong,Lu, Yongliang,Feng, Huayi,Zhang, Xiangyi,Zhao, Wenlei,Wang, Chenfeng,Wang, Tao,Wu, Shengpan,Huang, Techno-Press 2022 Advances in nano research Vol.12 No.6

The prolyl 3-hydroxylase family member 4 (P3H4), is associated with post-translational modification of fibrillar collagens and aberrantly activated in cancer leading to tumor progression. However, its role in clear cell renal cell carcinoma (ccRCC) is still unknown. Here we reported that P3H4 was highly expressed in renal cancer tissues and significantly positive correlated with poor prognosis. Knockdown of P3H4 inhibited the proliferation, migration and metastasis of renal cancer cells in vitro and in vivo, and also, overexpression of it enhanced the oncogenic process. Mechanistically, P3H4 depletion decreased the levels of GDF15-MMP9 axis and repressed its downstream signaling. Further functional studies revealed that inhibition of GDF15 suppressed renal cancer cell growth and GDF15 recombinant human protein (rhGDF15) supplementation effectively rescued the inhibitory effect induced by P3H4 knockdown. Moreover, decreased levels of MMP9 caused by inhibition of P3H4-GDF15 signaling constrained the expression of PD-L1 and suppression of P3H4 accordingly promoted anti-tumor immunity via stimulating the infiltration of CD4+ and CD8+ T cells in syngeneic mice model. Taken together, our findings firstly demonstrated that P3H4 promotes ccRCC progression by activating GDF15-MMP9-PD-L1 axis and targeting P3H4-GDF15-MMP9 signaling pathway can be a novel strategy of controlling ccRCC malignancy.

Novel YBO3 phosphors doped with Ln3+ (Ce3+, Tb3+, Eu3+) ions with tunable color for WLED applications

Shuo Kang,Zhikui Yu,Qirong Tian,Minghui Tai,Jiaoying Wang,Dalai Jin,Longcheng Wang 대한금속·재료학회 2022 ELECTRONIC MATERIALS LETTERS Vol.18 No.6

In this work, YBO3phosphors doped with Ln3+(Ce3+, Tb3+,Eu3+)ions were synthesized by a facile hydrothermal methodusing high temperature and high pressure environment. Structural property characterizations show all the samples have asimilar spherical morphology and a hexagonal crystal structure with good crystallinity. PL spectra and CIE calculation showthat the color of phosphors can be easily controlled by the species and atomic content of Ln3+ions. White color is achievedas the atomic contents of Ln3+ions are: 1% Ce3+,3% Tb3+,and 0.5% Eu3+,respectively. Furthermore, LED devices basedon ultraviolet chip were fabricated and characterized, and the results clearly demonstrated the tunable color of as-preparedphosphors. At the same time, co-doping Ce3+,Tb3+,and Eu3+ions can well adjust the fluorescence lifetime of the threerare earth ions through energy transfer. These results show that the phosphor has broad application prospects in the field ofdisplay lighting such as LED.

Evaluation and Comparation of a Novel Surgical Technique and Hemivertebra Resection to the Correction of Congenital Cervical Scoliosis in Lower Cervical and Cervicothoracic Spine

Shuo Cao,Xin Chen,Shengfa Pan,Yinze Diao,Yanbin Zhao,Tian Xia,Weishi Li,Feifei Zhou,Yu Sun 대한척추신경외과학회 2022 Neurospine Vol.19 No.4

Objective: To report concave-side distraction technique to treat congenital cervical scoliosis in lower cervical and cervicothoracic spine. To evaluate and compare clinical and radiographic results of this procedure with classic hemivertebra resection procedure. Methods: This study reviewed 29 patients in last 13 years. These patients were divided into convex-side resection group (group R) and concave-side distraction group (group D). Radiographic assessment was based on parameter changes preoperatively, postoperatively and at last follow-up. Demographic data, surgical data and complications were also evaluated and compared between the 2 groups. Results: In group R, mean age was 8.9 ± 3.3 years and follow-up was 46 ± 18 months. Operation time and blood loss averaged 500 ± 100 minutes, 703 ± 367 mL. In group D, mean age was 9.9 ± 2.8 years and follow-up was 34 ± 14 months. Operation time and blood loss averaged 501 ± 112 minutes, 374 ± 181 mL. Structural Cobb angle was corrected from 29.4° ± 12.5° to 5.3° (2.1°–18.1°) (p = 0.001) and 33.7° ± 14.1° to 12.8° ± 11.4° (p < 0.001) in groups R and D. Compensatory Cobb angle had a spontaneous correction rate of 59.6% (40.0%–80.8%) and 59.7% ± 23.0% in groups R and D. Mandibular incline, clavicle angle and spine coronal balance were significantly improved at last follow-up in both groups. All correction rates were not statistically different between groups. However, group D had significant less blood loss (p < 0.001) and operation time (p = 0.004) per vertebra than group R. Seven patients developed C5 nerve root palsy and recovered by 6 months of follow-up. Conclusion: Both surgical procedures are safe and effective in correcting congenital cervical scoliosis. But concave-side distraction technique has less blood loss and time-consuming during surgery, which provides a better option for the treatment of congenital cervical scoliosis.

Compound K attenuates hyperglycemia by enhancing glucagon-like peptide-1 secretion through activating TGR5 via the remodeling of gut microbiota and bile acid metabolism

Tian, Fengyuan,Huang, Shuo,Xu, Wangda,Chen, Lan,Su, Jianming,Ni, Haixiang,Feng, Xiaohong,Chen, Jie,Wang, Xi,Huang, Qi The Korean Society of Ginseng 2022 Journal of Ginseng Research Vol.46 No.6

Background: Incretin impairment, characterized by insufficient secretion of L-cell-derived glucagon-like peptide-1 (GLP-1), is a defining step of type 2 diabetes mellitus (T2DM). Ginsenoside compound K (CK) can stimulate GLP-1 secretion; however, the potential mechanism underlying this effect has not been established. Methods: CK (40 mg/kg) was administered orally to male db/db mice for 4 weeks. The body weight, oral glucose tolerance, GLP-1 secretion, gut microbiota sequencing, bile acid (BA) profiles, and BA synthesis markers of each subject were then analyzed. Moreover, TGR5 expression was evaluated by immunoblotting and immunofluorescence, and L-cell lineage markers involved in L-cell abundance were analyzed. Results: CK ameliorated obesity and impaired glucose tolerance in db/db mice by altering the gut microbiota, especially Ruminococcaceae family, and this changed microbe was positively correlated with secondary BA synthesis. Additionally, CK treatment resulted in the up-regulation of CYP7B1 and CYP27A1 and the down-regulation of CYP8B1, thereby shifting BA biosynthesis from the classical pathway to the alternative pathway. CK altered the BA pool by mainly increasing LCA and DCA. Furthermore, CK induced L-cell number expansion leading to enhanced GLP-1 release through TGR5 activation. These increases were supported by the upregulation of genes governing GLP-1 secretion and L-cell differentiation. Conclusions: The results indicate that CK improves glucose homeostasis by increasing L-cell numbers, which enhances GLP-1 release through a mechanism partially mediated by the gut microbiota-BA-TGR5 pathway. Therefore, that therapeutic attempts with CK might be useful for patients with T2DM.

Selection of inspection path optimization scheme based on analytic hierarchy process and inspection experimental study

Shuo Zhang,Jiantao Yao,Ruochao Wang,Yu Tian,Jiaxin Wang,Yongsheng Zhao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.1

This paper mainly studies the optimization of the patrol route of a fire inspection robot, based on analytic hierarchy process (AHP) and fire source detection. First, the A* algorithm is improved based on two aspects of the heuristic function and of the obstacle boundary setting, while the suboptimal path is obtained in MATLAB. Next, the path planned according to the improved A* algorithm is smoothed and optimized, by means of gradient descent method, Bezier curve and B-spline curve, while the index parameters are optimized by means of MATLAB simulation. In view of the simulation results, the trajectory optimization performance index evaluation system, established by five decision criteria, including running time, path length, ride comfort, no-collision effect and quadratic optimization space, is put forward. The three kinds of optimization methods are analyzed qualitatively and quantitatively, and the results show that, in the total hierarchical ranking, the B-spline curve trajectory optimization scheme has the largest weight and is more important than the other two schemes. Finally, the superiority of B-spline curve is verified experimentally.

A new red-emitting phosphor of Eu3+-doped Sr2MgMoxW1−xO6 for solid state lighting

Shuo Li,Xiantao Wei,Kaimo Deng,Xiuna Tian,Yanguang Qin,Yonghu Chen,Min Yin 한국물리학회 2013 Current Applied Physics Vol.13 No.7

The white light-emitting diode has recently attracted great attention as a promising candidate for next generation lighting. The solid solution of Sr1.80Eu0.10Li0.10MgMoxW1-xO6 was synthesized via hightemperature solid-state reaction and this solid solution is treated as a promising red emitting phosphor for white light-emitting diodes. In our cases, the X-ray diffraction, excitation spectra, emission spectra and decay curves of these solid solutions were measured as a function of the Mo/W ratio to characterize the structural and luminescent properties. The excitation bands of the series of phosphors are consistent well with the region of near ultraviolet light, and the phosphors present better color purity than the commercial phosphor Y2O2S:Eu3þ in current use. Taking these properties into consideration,this kind of material may find a great potential application as a red phosphor for near-ultraviolet excited white light-emitting diodes.

Diabetes Mellitus Is Associated with Inferior Prognosis in Patients with Chronic Lymphocytic Leukemia: A Propensity Score-Matched Analysis

Rui Gao,Tian-Shuo Man,Jin-Hua Liang,Li Wang,Hua-Yuan Zhu,Wei Wu,Lei Fan,Jian-Yong Li,Tao Yang,Wei Xu 대한암학회 2020 Cancer Research and Treatment Vol.52 No.1

Purpose Diabetes mellitus (DM) is associated with elevated cancer risk and poor survival outcome in malignancies. The objective of this study was to evaluate the prognostic value of preexisting DM in chronic lymphocytic leukemia (CLL). Materials and Methods Six hundred and thirty-three subjects with newly-diagnosed CLL between 2007 and 2016 were recruited. Propensity score-matched method was performed to balance baseline characteristics and eliminate possible bias. Univariate and multivariate Cox regression analyses screened the independent risk indicators for time-to-first-treatment (TTFT) and cancer-specific survival (CSS) of CLL. Receiver operator characteristic curves and the corresponding areas under the curve assessed the predictive accuracy of CLL–International Prognostic Index (IPI) together with DM. Results The results showed that 111 patients had pre-existing DM. In the propensity-matched cohort, DM was correlated with inferior TTFT and CSS in CLL patients, and it was an independent prognostic factor for both CSS and TTFT. Pre-diabetics also shared undesirable prognostic outcome compared with patients with no diabetic tendency, and a positive association between longer diabetic duration and poorer prognosis of CLL was identified. DM as one additional point to CLL-IPI had larger area under the curve compared with CLLIPI alone in CSS prediction and could improve the prognostic capacity of CLL-IPI. Conclusion Pre-existing DM was found to be a valuable prognostic predictor and could help predict life expectancy and build refined prognostication models for CLL.

A Review of Industrial MIMO Decoupling Control

Lu Liu,Siyuan Tian,Dingyu Xue,Tao Zhang,YangQuan Chen,Shuo Zhang 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.5

In recent decades, MIMO (Multi-Input-Multi-Output) systems become more and more widely used inindustrial applications. A variety of decoupling control algorithms have been studied in the literature. Therefore,a review of the most extensively applied coupling interaction analysis and decoupler design methods for industrialprocesses is necessary to be carried out. In this paper, in order to benefit researchers and engineers with differentacademic backgrounds, the scattered coupling interaction analysis and decoupling algorithms are collectedand divided into different categories with their characteristics, application domains and informative comments forselection. Moveover, some frequently concerned problems of decoupling control are also discussed.

Study on the Fracture Toughness of Polypropylene-Basalt Fiber-Reinforced Concrete

Ninghui Liang,Lianxi Ren,Shuo Tian,Xinrong Liu,Zuliang Zhong,Zhiyun Deng,Ru Yan 한국콘크리트학회 2021 International Journal of Concrete Structures and M Vol.15 No.5

To study the hybrid effects of polypropylene fiber and basalt fiber on the fracture toughness of concrete, 13 groups of notched concrete beam specimens with different fiber contents and mass ratios were prepared for the three-point bending test. Based on acoustic emission monitoring data, the initiation cracking load and instability load of each group of specimens were obtained, and the fracture toughness parameters were calculated according to the double- K fracture criterion. The test results show that the basalt fiber-reinforced concrete has a greater increase in initial fracture toughness, and the toughness of coarse polypropylene fiber-reinforced concrete is more unstable. Moreover, after the coarse polypropylene fiber content reaches 6 kg/m³ and the basalt fiber content reaches 3 kg/m³, increasing the content will not significantly improve the fracture toughness of the concrete. The polypropylene-basalt fiber will produce positive and negative effects when mixed, and the mass ratio of 2:1 was optimal. Finally, the fitting analysis revealed that the fracture process of polypropylene-basalt fiber-reinforced concrete (PBFRC) can be objectively described by the bilinear softening constitutive curve improved by Xu and Reinhardt.