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- 저자 : Tian Yushun (검색결과 2 건)
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A Windowed-Total-Variation Regularization Constraint Model for Blind Image Restoration
Ganghua Liu,Wei Tian,Yushun Luo,Juncheng Zou,Shu Tang 한국정보처리학회 2022 Journal of information processing systems Vol.18 No.1
Blind restoration for motion-blurred images is always the research hotspot, and the key for the blind restorationis the accurate blur kernel (BK) estimation. Therefore, to achieve high-quality blind image restoration, thisthesis presents a novel windowed-total-variation method. The proposed method is based on the spatial scale ofedges but not amplitude, and the proposed method thus can extract useful image edges for accurate BKestimation, and then recover high-quality clear images. A large number of experiments prove the superiority.
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Jeong, Hyun-Joo,Yushun, Tian,Kim, Bohye,Nam, Mi-Young,Lee, Hyun-A,Yoo, Yun-Jung,Seo, Jeong-Taeg,Shin, Dong-Min,Ohk, Seung-Ho,Lee, Syng-Ill Korean Academy of Oral Biology and the UCLA Dental 2005 International Journal of Oral Biology Vol.30 No.1
Bone remodeling is a process controlled by the action of two major bone cells; the bone forming osteoblast and the bone resorbing osteoclast. In the process of osteoclastogenesis, stromal cells and osteoblast produce RANKL, OPG, and MCSF, which in turn regulate the osteoclastogenesis. During the bone resorption by activated osteoclasts, extra cellular Ca^(2+)/PO^(2-)₄ concentration and degraded organic materials goes up, providing the hypertonic microenvironment. In this study, we tested the effects of hypertonicity due to the degraded organic materials on osteoclastogenesis in co-culture system. It was examined the cellular response of osteoblastic cell in terms of osteoclastogenesis by applying the sucrose, and mannitol, as a substitute of degraded organic materials to co-culture system. Apart from the sucrose, mannitol, and NaCl was tested to be compared to the effect of organic osmotic particles. The addition of sucrose and mannitol (25, 50, 100, 150, or 200mM) to coculture medium inhibited the number of tartrate-resistant acid phosphatase (TRAP) positive multinucleated cells induced by 10nM lα, 25(OH)₂vitaminD₃ (lα, 25(OH)₂D₃). However, NaCl did exert harmful effect upon the cells in this co-culture system, which is attributed to DNA damage in high concentration of NaCl. To further investigate the mechanism by which hypertonicity inhibits lα, 25(OH)₂D₃induced osteoclastogenesis, the mRNA expressions of receptor activator of nuclear factor (NF)-kB ligand (RANKL) and osteoprotegerin (OPG) were monitored by RT-PCR. In the presence of sucrose (50mM), RANKL mRNA expression was decreased in a dose-dependent manner, while the change in OPG and M-CSF mRNA were not occurred in significantly. The RANKL mRNA expression was inhibited for 48 hours in the presence of sucrose (50mM), but such a decrement recovered after 72 hours. However, there were no considerable changes in the expression of OPG and M-CSF mRNA. Conclusively, these findings strongly suggest that hypertonic stress down-regulates lα, 25(OH)₂D₃-induced osteoclastogenesis via RANKL signal pathway in osteoblastic cell, and may play a pivotal role as a regulator that modulates osteoclastogenesis.
ScienceON
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