http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A Dilute-and-Shoot LC-MS/MS Method for Screening of 43 Cardiovascular Drugs in Human Urine
( Thuy-vy Pham ),( Gunhee Lee ),( Xuan-lan Mai ),( Thi-anh-tuyet Le ),( Thi Ngoc Van Nguyen ),( Jongki Hong ),( Kyeong Ho Kim ) 한국질량분석학회 2021 Mass spectrometry letters Vol.12 No.1
A simple, specific, and economical LC-MS/MS method was investigated for the screening of 43 prescribed antihypertensive and related drugs in human urine. The urine samples were simply prepared by diluting and mixing with internal standard before directly introduced to the LC-MS/MS system, which is fast, straightforward, and cost-effective. Fractional factorial, Box-Behnken, and I-optimal design were applied to screen and optimize the mass spectrometric and chromatographic factors. The analysis was carried out on a triple quadrupole mass spectrometer system utilizing multiple reaction monitoring with positive and negative electrospray ionization method. Chromatographic separation was performed on a Thermo Scientific Accucore RP-MS column (50 × 3.0 mm ID., 2.6 μm) using two separate gradient elution programs established with the same mobile phases. Chromatographic separation was performed within 12 min. The optimal method was validated based on FDA guideline. The results indicated that the assay was specific, reproducible, and sensitive with the limit of detection from 0.1 to 50.0 μg/L. The method was linear for all analytes with coefficient of determination ranging from 0.9870 to 0.9981. The intra-assay precision was from 1.44 to 19.87% and the inter-assay precision was between 2.69 and 18.54% with the recovery rate ranges from 84.54 to 119.78% for all drugs measured. All analytes in urine samples were stable for 24 h at 25℃, and for 2 weeks at -60℃. The developed method improves on currently existing methods by including larger number of cardiovascular medications and better sensitivity of 12 analytes.
Thuy-Vy Pham,Xuan Lan Mai,Thi-Anh-Tuyet Le,이재용,이건희,김대중,한상범,김경호 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.9
A simple, cost-effective, and greener HPLC method was investigated to determine 14 ?-lactams. To achieve this, various strategies were implemented such as the use of an aqueous mobile phase, ionic liquids, or an alternative organic solvent. Preliminary experiments were conducted using ?one-factor-at-a-time? to identify the significant factors affecting chromatographic performance. The experimental design (central composite design) was then applied to thoroughly examine the effects of the key factors and exploit them to achieve optimal HPLC condition. The developed method was less hazardous and improved the retention and peak shape, compared with other conventional methods. The optimized assay condition was validated according to the ICH guidelines and effectively applied for the quantification of some ?-lactams in various formulations. These results imply that this novel HPLC method can be employed for routine analyses of some ?-lactams in pure drug and commercial formulations.
Pham, Thuy-Vy,Mai, Xuan-Lan,Song, Ha-Ram,Ahn, Soo-Bin,Cha, Min-Jeong,Kang, Jong-Seong,Woo, Mi Hee,Na, Dong-Hee,Chun, In-Koo,Kim, Kyeong Ho The Korean Society of Analytical Science 2018 분석과학 Vol.31 No.2
A simple, sensitive, and selective high-performance liquid chromatography (HPLC) method was developed and validated for the simultaneous quantification of fluorometholone (FLU) and tetrahydrozoline hydrochloride (THZ) in combined ophthalmic formulations. The effects of several factors, including detection wavelength, buffer pH, buffer concentration, and organic solvent concentration, on the performance of the method were investigated. The performance of the developed method was validated in accordance with the requirements of the International Conference on Harmonization. The linearity of the calibration curves in the desired concentration range was high for both FLU and THZ ($r^2=0.9999$). The accuracy and precision of the method were determined by a recovery study at analyte concentrations of 80 %, 100 %, and 120 %. The recovery was 99.60-100.17 % for both analytes, with a relative standard deviation less than 1.0 % at any concentration level. The validated results indicate that the new HPLC method could be successfully applied for the simultaneous determination of FLU and THZ in ophthalmic suspensions.
Detecting Knowledge structures in Impact Investment for Social Enterprise
Duong Thuy Vy Pham,Jaewon Choi 한국인터넷전자상거래학회 2020 인터넷전자상거래연구 Vol.20 No.2
Investors around the world are making impact investments to unleash the power of capital for good. The growing impact investment market provides capital to address the world’s most pressing challenges in sectors such as climate change, sustainable agriculture, renewable energy, conservation, etc and affordable and accessible basic services including housing, healthcare, and education. Social impact investing is becoming a hot issue in the social enterprises field recently. However, there is a lack of research on the practical measures for social impact investment. Therefore, in this study, we want to confirm the research trend by collecting data related to social impact investment in recent 5 years. In this study, social impact investment related papers from 2015 to 2020, March were collected using smart medical topics, and the social impact investment papers were rearranged based on this. Research trend analysis uses LDA topic modeling technique for topic information of theses, constructs topic network based on relation of topics, and tries to find out the main future research trends through topic.