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Tetsuhiro Ishikawa,Atsuya Watanabe,Hiroto Kamoda,Masayuki Miyagi,Gen Inoue,Kazuhisa Takahashi,Seiji Ohtori 대한척추외과학회 2018 Asian Spine Journal Vol.12 No.2
Study Design: An in vivo histologic and magnetic resonance imaging (MRI) study of lumbar intervertebral disc (IVD) degeneration was conducted. Purpose: To clarify the sensitivity and efficacy of T1ρ/T2 mapping for IVD degeneration, the correlation between T1ρ/T2 mapping and degenerative grades and histological findings in the lumbar IVD were investigated. Overview of Literature: The early signs of IVD degeneration are proteoglycan loss, dehydration, and collagen degradation. Recently, several quantitative MRI techniques have been developed; T2 mapping can be used to evaluate hydration and collagen fiber integrity within cartilaginous tissue, and T1ρ mapping can be used to evaluate hydration and proteoglycan content. Methods: Using New Zealand White rabbits, annular punctures of the IVD were made 10 times at L2/3, 5 times at L3/4, and one time at L4/5 using an 18-gauge needle (n=6) or a 21-gauge needle (n=6). At 4 and 8 weeks post-surgery, MRI was performed including T1ρ and T2 mapping. The degree of IVD degeneration was macroscopically assessed using the Thompson grading system. All specimens were cut for hematoxylin and eosin, safranin-O, and toluidine blue staining. Results: Disc degeneration became more severe as the number of punctures increased and when the larger needle was used. T1ρ and T2 values were significantly different between grade 1 and grade 3 IVDs, grade 1 and grade 4 IVDs, grade 2 and grade 3 IVDs, and grade 2 and grade 4 IVDs (p <0.05). There was a significant difference between grade 1 and grade 2 IVDs only in terms of T1ρ values (p <0.05). Conclusions: T1ρ and T2 quantitative MRI could detect these small differences. Our results suggest that T1ρ and T2 mapping are sensitive to degenerative changes of lumbar IVDs and that T1ρ mapping can be used as a clinical tool to identify early IVD degeneration.
Minamidani, Tetsuhiro,Tanaka, Takanori,Mizuno, Yoji,Mizuno, Norikazu,Kawamura, Akiko,Onishi, Toshikazu,Hasegawa, Tetsuo,Tatematsu, Ken'ichi,Takekoshi, Tatsuya,Sorai, Kazuo,Moribe, Nayuta,Torii, Kazufu American Institute of Physics 2011 The Astronomical journal Vol.141 No.3
<P>In order to precisely determine the temperature and density of molecular gas in the Large Magellanic Cloud, we made observations of the optically thin <SUP>13</SUP>CO(J = 3-2) transition using the ASTE 10 m telescope toward nine peaks where <SUP>12</SUP>CO(J = 3-2) clumps were previously detected with the same telescope. The molecular clumps include those in giant molecular cloud (GMC) Types I (with no signs of massive star formation), II (with H <SPAN CLASS='sml'>II</SPAN> regions only), and III (with H <SPAN CLASS='sml'>II</SPAN> regions and young star clusters). We detected <SUP>13</SUP>CO(J = 3-2) emission toward all the peaks and found that their intensities are 3-12 times lower than those of <SUP>12</SUP>CO(J = 3-2). We determined the intensity ratios of <SUP>12</SUP>CO(J = 3-2) to <SUP>13</SUP>CO(J = 3-2), R<SUP>12/13</SUP><SUB>3-2</SUB>, and <SUP>13</SUP>CO(J = 3-2) to <SUP>13</SUP>CO(J = 1-0), R<SUP>13</SUP><SUB>3-2/1-0</SUB>, at 45'' resolution. These ratios were used in radiative transfer calculations in order to estimate the temperature and density of the clumps. The clumps have a kinetic temperature range of T<SUB>kin</SUB> = 15-200 K and a molecular hydrogen gas density range of n(H<SUB>2</SUB>) = 8 × 10<SUP>2</SUP>-7 × 10<SUP>3</SUP> cm<SUP>–3</SUP>. We confirmed that the higher density clumps have higher kinetic temperature and that the lower density clumps have lower kinetic temperature to better accuracy than in previous work. The kinetic temperature and density increase generally from a Type I GMC to a Type III GMC. We interpret that this difference reflects an evolutionary trend of star formation in molecular clumps. The R<SUP>13</SUP><SUB>3-2/1-0</SUB> and kinetic temperature of the clumps are well correlated with the Hα flux, suggesting that the heating of molecular gas with density n(H<SUB>2</SUB>) = 10<SUP>3</SUP>-10<SUP>4</SUP> cm<SUP>–3</SUP> can be explained by stellar far-ultravoilet photons.</P>
현민경,Tetsuhiro Yoshino 대한예방한의학회 2022 대한예방한의학회지 Vol.26 No.1
Objectives : Evidence supporting the cold-heat symptom and sasang constitution type, which are diagnostic items of traditional Korean medicine, is needed to manage sleep disturbances, which is a typical symptom of mibyeong (subhealth). This study examined the association between each cold-heat symptom and sleep disturbances according to each sasang constitution type. Methods : This research was a cross-sectional study of 5,793 subjects from the Korean Medicine Data Center (KDC) community cohort survey. The association between each cold-heat symptom and sleep disturbances was analyzed by logistic regression analysis adjusted for several demographic variables. Subgroup analysis was then performed for each type of sasang constitution. Results : The soeum and soyang types were 1.53 and 1.26 times more likely to have sleep disturbances than the taeum type. Sleep disturbances were associated with ‘coldness of the abdomen’, ‘watery mouth’ in the cold domain items, and ‘body feverishness’, ‘flushed face and eye’, ‘thirst’, and ‘scanty dark urine’ in the heat domain items. The soeum and soyang types were 1.55 and 1.39 times more likely to sleep less than five hours per night than the taeeum type. In addition, the associations of those showed a different pattern for each sasang constitution type. Conclusions : Sleep disturbances are associated with specific cold-heat symptoms, and the associated coldheat symptoms differ according to the sasang constitution type. These results may help traditional medicine specialists select customized interventions for patients with sleep disturbances.
Experimental and numerical flow analysis in hydraulic vane pump
Junichi SUEMATSU,Tetsuhiro TSUKIJI,Mariko WATANABE,Shinji YAKABE,Hirohito WATANABE,Yoshinari NAKAMURA,Kazunari SUZUKI 유공압건설기계학회 2015 유공압건설기계학회 학술대회논문집 Vol.2015 No.10
The purpose of this study is to conduct a three dimensional flow analysis of a hydraulic vane pump by using computational fluid dynamics (CFD), to evaluate an accuracy of volumetric flow rate in CFD compared to experimental value and to examine a influence of the evaporation coefficient and condensation coefficient in Zwart–Gerber–Belamri cavitation model to pressure in a vane chamber. In this study, standard k-ε turbulent model with the Zwart–Gerber–Belamri cavitation model is used to estimate the cavitating flow in vane pump. In CFD, two notch models are used. From results of experiments and CFD analysis of volumetric flow rate, there is little difference between the experiments and CFD results in the low speed range. However, for high speed range, in a case with no cavitation model, the CFD results of volumetric flow rate are different from the experimental ones. On the other hand, in the case with cavitation model, those agree with the experimental values. In this case, the error of volumetric flow rate is less than 1% in the low speed range and less than 2.5% in the high speed range. From CFD results of pressure fluctuation in a vane chamber when the evaporation coefficient and condensation coefficient in the cavitation model are varied, the surge pressure can be seen in a vane chamber. In conclusion, it could be considered that the CFD calculation with cavitation model is sufficiently accurate in volumetric flow rate. In addition, as the evaporation coefficient becomes large, amplitude of the pressure fluctuation in a vane chamber after a surge pressure becomes large, as the condensation coefficient becomes large, the surge pressure in a vane chamber becomes low.
The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis
( Hyunsoo Kim ),( Tetsuhiro Kajikawa ),( Matthew C. Walsh ),( Noriko Takegahara ),( Yun Hee Jeong ),( George Hajishengallis ),( Yongwon Choi ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.9
Purinergic receptor signaling is increasingly recognized as an important regulator of inflammation. The P2X family purinergic receptors P2X5 and P2X7 have both been implicated in bone biology, and it has been suggested recently that P2X5 may be a significant regulator of inflammatory bone loss. However, a role for P2X5 in periodontitis is unknown. The present study aimed to evaluate the functional role of P2X5 in ligatureinduced periodontitis in mice. Five days after placement of ligature, analysis of alveolar bone revealed decreased bone loss in P2rx5<sup>-/-</sup> mice compared to P2rx7<sup>-/-</sup> and WT control mice. Gene expression analysis of the gingival tissue of ligated mice showed that IL1b, IL6, IL17a and Tnfsf11 expression levels were significantly reduced in P2rx5<sup>-/-</sup> compared to WT mice. These results suggest the P2X5 receptor may regulate bone loss related to periodontitis and it may thus be a novel therapeutic target in this oral disease. [BMB Reports 2018; 51(9): 468-473]
Takashi Yurube,Tetsuhiro Iguchi,Keisuke Kinoshita,Takashi Sadamitsu,Kenichiro Kakutani 대한척추신경외과학회 2021 Neurospine Vol.18 No.4
The retro-odontoid pseudotumor is often concurrent with atlantoaxial subluxation (AAS). Therefore, the pseudotumor is relatively common in rheumatoid arthritis (RA) but rare in primary osteoarthritis (OA). This is a case report of an elderly male patient suffering from neck pain and compression myelopathy caused by the craniocervical pseudotumor with OA but without atlantoaxial instability. He had long-lasting peripheral and spinal pain treated by nonsteroidal anti-inflammatory drugs. Imaging found upper cervical spondylosis without AAS or dynamic instability but with periodontoid calcifications and ossifications, suggesting calcium pyrophosphate dihydrate (CPPD) crystal deposition. Based on a comprehensive literature search and review, CPPD disease around the atlantodental joint is a possible contributor to secondary OA development and retro-odontoid pannus formation through chronic inflammation, which can be enough severe to induce compression myelopathy in non-RA patients without AAS. The global increase in the aged population advises caution regarding more prevalent upper cervical spine disorders associated with OA and CPPD.