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Novel Flyback DC-DC Converter with Improved Stability and Dynamic Response
Hiroto Terashi,Isaac Cohen,Tamotsu Ninomiya 전력전자학회 2001 ICPE(ISPE)논문집 Vol.2001 No.10
This paper proposes a novel flyback topology and its control scheme, where some disadvantages of the conventional one are eliminated while the circuit simplicity is maintained, and furthermore confirms the improvement of its dynamic response and stability analytically and experimentally.<br/>
The Analysis of characteristics on conventional and novel flyback converter with Leakage-Inductance
Hiroto Terashi,Tamotsu Ninomiya 전력전자학회 2004 ICPE(ISPE)논문집 Vol.- No.-
Static and dynamic characteristics of both the novel flyback converter proposed before and the conventional one are analyzed including the effect of transformer leakage inductances, and the results are confirmed experimentally. The leakage inductances make the current-commutation periods increase. As a result, the voltage conversion ratio is decreased from the static viewpoint, and the damping factor in dynamics is increased. Therefore, the existence of leakage inductances deteriorates the energy-transfer process, and on the other hand, makes the converter dynamics more stable.
The effect of three Korean traditional medicines on the growth rate of cultured human keratinocytes
Chung, Seok Hee,Hiroto Terashi,Lenore M. Rhodes,Moon, Namdoo,William R. Dunham,Cynthia L. Marcelo 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
The effect of three different Korean Traditional Medicines (KTM) was studied on several functional parameters of adult human cells in culture. The cells were non-transformed strains of normal, skin epidermal cells (keratinocytes) from adult humans. Aqueous extracts of the herbal medicines were tested using two types of cell strains: one type was essential fatty acid deficient (EFAD) cells which grow rapidly in medium that was low in calcium and had no essential fatty acids; the second type was a cell strain grown in medium supplemented with essential fatty acid (EFA-supplemented). These cells had much slower, in vivo skin growth rates, and the fatty acid composition resembled that measured in epidermal biopsy tissue. The KTMs chosen for this study were tae-gang-hual-tang (for treating osteoarthritis), hual-ak-tang (for pain relief) and sip-zeon-tae-bo-tang (for fortifying immune systems). Because high proliferation rates usually correlate with skin inflammation and because many of the chemotactic agents mediating inflammatory response are modified fatty acids, this study focused on cell growth rate and membrane fatty acid composition as signals for the effects of the herbal medicines. By monitoring growth rate, these experiments measured both a stimulatory and a regulatory effect on the growth of keratinocytes. Some toxicity was seen at the highest doses of the KTMs. These effects were modeled mathematically, and the results showed varying effects on growth rate depending on dose and herbal recipe. The fitting parameters were discussed as they relate to biological function. The experimental design was also discussed and alternatives were suggested. ⓒ 2001 Elsevier Science lreland Ltd. All rights reserved.
Original Article : Role of UCP2 Expression after Hepatic Warm Ischemia-Reperfusion in the Rat
( Mizuki Ninomiya ),( Ken Shirabe ),( Mitsuo Shimada ),( Takahiro Terashi ),( Yoshihiko Maehara ) 대한간학회 2011 Gut and Liver Vol.5 No.4
Background/Aims: The role of uncoupling protein-2 (UCP2) in the liver is currently unclear. Emerging evidence suggests a relationship between UCP2 and oxidative stress. In the present study, we tested the hypothesis that UCP2 expression in the liver might change during warm ischemia-reperfusion (I/R) according to oxidative stress. Methods: Wistar rats were subjected to 40 (short ischemia) or 90 (long ischemia) minutes of partial lobar ischemia followed by 4 hours of reperfusion. UCP2 expression in the ischemic and nonischemic lobes was assessed using reverse transcription-polymerase chain reaction and immunohistochemistry. Malondialdehyde concentrations in the liver tissue were also compared. Results: Malondialdehyde concentrations in the ischemic lobes were significantly higher in the long ischemia group. In the ischemic lobes of the short ischemia group, UCP2 protein expression was induced in hepatocytes, which did not express the protein prior to treatment, and the expression levels were higher than in the long ischemia group. The intralobular distribution of UCP2 seemed to correlate inversely with that of the necrotic area. UCP2 expression was observed, even in nonischemic lobes with similar intralobular heterogeneity. Conclusions: UCP2 was induced in hepatocytes after warm I/R. Although the primitive role of UCP2 expression may be cytoprotective in nature, its actual protective effect in hepatic I/R may be minimal. (Gut Liver 2011;5:486-492)
Effect of Serum Perampanel Concentration on Sporadic Amyotrophic Lateral Sclerosis Progression
Haruhisa Kato,Makiko Naito,Tomoko Saito,Takuto Hideyama,Hiroo Terashi,Shin Kwak,Hitoshi Aizawa 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.3
Background and Purpose To clarify the effect of perampanel (PER) on sporadic amyotrophic lateral sclerosis (sALS) progression, the relationship between the changes in Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) scores and serum PER concentrations was investigated. Methods 12 patients with sALS from our hospital who agreed to participate and completed the PER for sALS randomized phase 2 study were included. After completing the study, we retrospectively obtained serum PER concentration data from the patients. Based on their mean PER concentrations, we divided the patients who had been taking PER into two groups: four patients with a mean PER concentration of ≥400 ng/mL were assigned to the H group, and three with a mean PER concentration of <400 ng/mL were assigned to the L group. The control group consisted of five patients who had been taking a placebo. We obtained the ALSFRS-R scores of each patient at 36 and 48 weeks after randomization. The differences in ALSFRS-R scores at baseline (0 weeks) and each subsequent week were used in the analysis. Results At 48 weeks, there were no differences in the degree of deterioration of the bulbar, upper and lower limb, and respiratory ALSFRS-R subscores and total ALSFRS-R score. However, at 36 weeks, the bulbar subscore was significantly lower in the H group than in the control group (p=0.032). Conclusions Because high PER concentrations may exacerbate bulbar symptoms in patients with sALS, serum PER measurements may be beneficial when patients with sALS are taking PER.
A Novel Boost-Input Full-Bridge Converter
Takahiro Sonoda,Tamotsu Ninomiya,Satoshi Tomioka,Kei Sato,Hiroto Terashi 전력전자학회 2005 JOURNAL OF POWER ELECTRONICS Vol.5 No.3
In order to correct the power boost topology has been used for easy control. But conventional boost topology has the following drawbacks: switching voltage surge, cross conduction current and right-half-plane zero of its control transfer function. Furthermore, in this topology the output voltage is always higher than the input voltage. As a result, a first-stage boost PFC converter needs to be connected with a second-stage DC-DC converter. A new topology which can be used as single stage PFC converter is proposed in this paper.
A Novel Boost-Input Full-Bridge Converter
Sonoda Takahiro,Ninomiya Tamotsu,Tomioka Satoshi,Sato Kei,Terashi Hiroto The Korean Institute of Power Electronics 2005 JOURNAL OF POWER ELECTRONICS Vol.5 No.3
In order to correct the power boost topology has been used for easy control. But conventional boost topology has the following drawbacks: switching voltage surge, cross conduction current and right-half-plane zero of its control transfer function. Furthermore, in this topology the output voltage is always higher than the input voltage. As a result, a first-stage boost PFC converter needs to be connected with a second-stage DC-DC converter. A new topology which can be used as single stage PFC converter is proposed in this paper.