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<sup>123</sup>I-Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice
Nakano, Atushi,Kawashima, Hidekazu,Miyake, Yoshinori,Zeniya, Tsutomu,Yamamoto, Akihide,Koshino, Kazuhiro,Temma, Takashi,Fukuda, Tetsuya,Fujita, Yoshiko,Kakino, Akemi,Kanaya, Shigehiko,Sawamura, Tatsuy 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.2
Purpose Oxidized low-density lipoprotein (oxLDL) plays a key role in endothelial dysfunction, vascular inflammation, and atherogenesis. The aim of this study was to assess blood clearance and in vivo kinetics of radiolabeled oxLDL in mice. Methods We synthesized $^{123}I-oxLDL$ by the iodine monochloride method, and performed an uptake study in CHO cells transfected with lectin-like oxLDL receptor-1 (LOX-1). In addition, we evaluated the consistency between the $^{123}I-oxLDL$ autoradiogram and the fluorescence image of DiI-oxLDL after intravenous injection for both spleen and liver. Whole-body dynamic planar images were acquired 10 min post injection of $^{123}I-oxLDL$ to generate regional time-activity curves (TACs) of the liver, heart, lungs, kidney, head, and abdomen. Regional radioactivity for those excised tissues as well as the bladder, stomach, gut, and thyroid were assessed using a gamma counter, yielding percent injected dose (%ID) and dose uptake ratio (DUR). The presence of $^{123}I-oxLDL$ in serum was assessed by radio-HPLC. Results The cellular uptakes of $^{123}I-oxLDL$ were identical to those of DiI-oxLDL, and autoradiograms and fluorescence images also exhibited consistent distributions. TACs after injection of $^{123}I-oxLDL$ demonstrated extremely fast kinetics. The radioactivity uptake at 10 min post-injection was highest in the liver ($40.8{\pm}2.4%$ ID). Notably, radioactivity uptake was equivalent throughout the rest of the body ($39.4{\pm}2.7%$ ID). HPLC analysis revealed no remaining $^{123}I-oxLDL$ or its metabolites in the blood. Conclusion $^{123}I-oxLDL$ was widely distributed not only in the liver, but also throughout the whole body, providing insight into the pathophysiological effects of oxLDL.
Tetsuya Kojima,Toshihiko Takauchi,Toshifumi Ise,Isao Iyoda,Hiroyuki Sasao,Yoshiyuki Kono,Koji Temma,Nobuyoshi Inoue,Akira Kawamoto 전력전자학회 2004 ICPE(ISPE)논문집 Vol.- No.-
A new parallel type voltage sag compensator is proposed. The proposed system can reduce the necessary capacity of a storage capacitor for voltage sag compensation by boost type power factor correction rectifier getting charging energy from residual voltage of utilities as it compensates the load voltage. This paper shows principle and control system of the proposed circuit. Compensation<br/> performances are demonstrated by experiments.