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Wati Linda Ratna,Sargowo Djanggan,Nurseta Tatit,Zuhriyah Lilik,Rahardjo Bambang 대한예방의학회 2023 예방의학회지 Vol.56 No.5
Objectives: Prolactin is vital for breastfeeding and milk production, and its secretion is influenced by factors related to the mother, infant, and environment. To date, no study has concurrently investigated the correlation of these factors with serum prolactin levels during lactation. Therefore, the objective of this study was to investigate the correlations among maternal and infant factors, lead exposure, and serum prolactin levels during lactation.Methods: A cross-sectional approach was employed in Surabaya, Indonesia, among 110 exclusively lactating mothers. The mothers’ daily diets were determined using multiple 24-hour recalls, while blood lead levels were measured with inductively coupled plasma mass spectrometry. Serum prolactin levels were assessed using the electrochemiluminescence immunoassay. For bivariate analysis, we employed the Spearman correlation, Mann-Whitney, and Kruskal-Wallis tests, while for multivariate analysis, we utilized multiple linear regression.Results: The average serum prolactin level of the lactating mothers was 129.19±88.96 ng/mL. Positive correlations were found between serum prolactin levels and breastfeeding frequency (<i>p</i> < 0.001), protein intake (<i>p</i> < 0.001), and calcium intake (<i>p</i> = 0.011) but had negative correlation with blood lead levels (<i>p</i> < 0.001) and vitamin B6 intake (<i>p</i> = 0.003). Additionally, prolactin levels were not significantly associated with maternal age; parity; intake of calories, vitamin D, vitamin E, zinc, folic acid, magnesium, or iron; infant age; or infant sex.Conclusions: Breastfeeding frequency had a stronger positive relationship with serum prolactin levels than protein and calcium intake. However, lead exposure was associated with reduced serum prolactin levels during lactation. Consequently, specific interventions from policymakers are necessary to manage breastfeeding in mothers exposed to lead.
Paulo Schiavom Duarte,Luciana Audi de Castroneves,Heitor Naoki Sado,Marcelo Tatit Sapienza,Ana Amélia Fialho de Oliveira Hoff,Carlos Alberto Buchpiguel 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.4
Herein, we report a case of a 19-year-old man with multiple endocrine neoplasia type 2B (MEN2B) and medullary thyroidcarcinoma (MTC) diagnosed when he was 12 years of age. The patient had previously undergone total thyroidectomy, cervicalradiotherapy, and chemotherapy. He progressed with known bone, pulmonary, and lymph node metastases and was scanned with18F-fluoride (18F-NaF) and 68Ga-dotatate whole-body positron emission tomography/computed tomography (PET/CT) for metastaticdisease monitoring.We found that the MTC bone metastases and soft tissue calcified metastases were better characterizedon 18F-NaF PET/CT than on 68Ga-dotatate PET/CT. This case illustrates that the 18F-NaF PET/CT could be helpful not only tothe detection of bone metastases but also to the detection of calcified soft tissue metastases in patients with MTC.
Ueda Cristina Emiko,Duarte Paulo Schiavom,Castroneves Luciana Audi,Coura-Filho George Barbério,Sado Heitor Naoki,Sapienza Marcelo Tatit,Ana Oliveira Hoff,Buchpiguel Carlos Alberto 대한핵의학회 2020 핵의학 분자영상 Vol.54 No.6
Purpose To compare the 18F-NaF PET/CT studies (18F-NaF) with other imaging methods in the detection of skeletal metastases (SM) in patients with medullary thyroid cancer (MTC). Methods We retrospectively analyzed 31 patients with MTC who performed 18F-NaF to assess SM. The results of the 18F-NaF were compared with other imaging methods performed for metastasis detection: 99Tc-MDP bone scan (BS), magnetic resonance imaging (MRI), contrast-enhanced CT (CT), and 68Ga-Dotatate and 18F-FDG PET/CT studies. A qualitative analysis comparing the 18F-NaF findings with the ones of the other methods was performed, and the results were classified as superior (>), equal (=), and inferior (<). Results Eleven patients had no bone metastases detected on any of the imaging methods used. Twenty patients presented SM depicted on 18F-NaF. Of these 20 patients, 12 performed bone scan (in 9 18F-NaF > BS and in 3 18F-NaF = BS), 1 performed 18F-FDG (18F-NaF > 18F-FDG), 4 performed 68Ga-Dotatate (in 2 18F-NaF > 68Ga-Dotatate and in 2 18F-NaF = 68Ga-Dotatate), 20 performed CT of at least one body segment (in 15 18F-NaF = CT and in 5 18F-NaF > CT), and 16 performed MRI of at least one body segment, and in all of them, the 18F-NaF was equal to the MRI. Beside this, the 18F-NaF detected SMin body segments not routinely scanned in MRI and CT. Conclusion In patients with MTC, the 18F-NaF seems to be equal or superior to other imaging modalities in the detection of SM and allows the analysis of the whole skeletal in a single study.