Association Between Overactive Bladder and Polyneuropathy in Diabetic Patients

Nermin Tanik,Serhat Tanik,Sebahattin Albayrak,Kürsat Zengin,Levent Ertugrul Inan,Emel Kiyak Caglayan,Asuman Celikbilek,Kadir Kirboga,Mesut Gurdal 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.3

Purpose: Diabetes mellitus (DM) is a chronic metabolic disorder that often leads to complications. We aimed to correlate two complications of DM, polyneuropathy and hyperactive bladder syndrome, using noninvasive measures, such as screening tests. Methods: We included 80 female and 40 male type 2 diabetic patients in this prospective study. Diabetic polyneuropathy evaluations were conducted using the Douleur Neuropathique 4 Questions (DN4), and overactive bladder (OAB) evaluations were performed using the Overactive Bladder Questionnaire (OAB-V8). The patients were also evaluated for retinopathy and nephropathy. The diabetic male and female patients with or without OAB were chosen and compared for microvascular complications (polyneuropathy, retinopathy, and nephropathy). Results: There were no significant correlations between OAB and retinopathy as well as between OAB and nephropathy among diabetic patients (female patients, P>0.05; male patients, P>0.05 ). However, the patients with OAB were significantly more likely to develop polyneuropathy (female patients, P<0.05; male patients, P<0.05). Conclusions: In diabetic patients, OAB and diabetic peripheral neuropathy are significantly correlated. These correlations were demonstrated using short, understandable, valid, and reliable disease-specific tests without invasive measures. Using these screening tests, both neurologists and urologists can easily diagnose these complications.

Is the Neutrophil-Lymphocyte Ratio an Indicator of Progression in Patients with Benign Prostatic Hyperplasia?

Tanik, Serhat,Albayrak, Sebahattin,Zengin, Kursad,Borekci, Hasan,Bakirtas, Hasan,Imamoglu, M. Abdurrahim,Gurdal, Mesut Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Purpose: The aim of this study was to evaluate inflammation parameters and assess the utility of the neutrophil-lymphocyte ratio (NLR) as a simple and readily available predictor for clinical disease activity in patients with nenign prostate hyperplasia BPH. We also aimed to investigate the relationship between inflammatory parameters with ${\alpha}$-blocker therapy response, and evaluate the potential association between NLR and the progression of benign prostatic hyperplasia (BPH). Materials and Methods: We examined 320 consecutive patients (July 2013-December 2013) admitted to our outpatient clinic with symptoms of the lower urinary tract at Bozok University. The mean age was 60 (range, 51-75) years. Complete blood count (CBC), prostate-specific antigen (PSA), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were assessed. Correlations between PSA, CRP, ESR, prostate volume, International Prostate Symptom Score (IPPS), maximum urinary flow rate (Qmax), and NLR were assessed statistically. Patients were divided into two groups: high and low risk of progression. Results: NLR was positively correlated with IPSS (p=0.001, r=0.265), PSA (p=0.001, r=0.194), and negatively correlated with Qmax (p<0.001, r=-0.236). High-risk patients a had a higher NLR compared with low-risk patients, based on IPSS (p<0.001), PSA (p=0.013), and Qmax (p<0.001); however, there were no significant differences between the groups in terms of age (p>0.05), and prostate volume (p>0.05). Conclusions: NLR can predict BPH progression. We propose that increased inflammation is negatively associated with clinical status in BPH patients and suggest that NLR can give information along with LUTS severity which may be used as a readikly accessible marker for patient follow-up.

DESIGN OF A VERY LIGHT L7E ELECTRIC VEHICLE PROTOTYPE

E. TANIK,V. PARLAKTAŞ 한국자동차공학회 2015 International journal of automotive technology Vol.16 No.6

Due to the diminishing fossil fuel and strict emission standards, electric vehicles are becoming more popular day by day. In many foundations, light electric vehicle prototypes are being built; however, their cost is generally very high. This paper introduces novel approaches for the design and manufacturing of a light electric vehicle prototype with very low cost. General design philosophy of such a prototype is presented. A theorem for the synchronization problem of two independent electric motors is proposed. Gear ratio optimization for acceleration performance, gradability, and top-speed of such electric vehicles is mentioned. Novel simplified suspension-steering kinematic design procedures are proposed. Approaches for mechanical design of a very light electric vehicle prototype are presented. The important concerns in those design approaches are low cost manufacturing processes and lightness by considering passive safety. A realistic impact loading scenario is proposed to determine the maximum force acting through a wheel of a vehicle. After the road tests performed, test results are presented and discussed. Finally, range of the car under various conditions is given.

Red Cell Distribution Width as a Predictor of Prostate Cancer Progression

Albayrak, Sebahattin,Zengin, Kursad,Tanik, Serhat,Bakirtas, Hasan,Imamoglu, Abdurrahim,Gurdal, Mesut Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Background: The aims of this study were to investigate the utility of red blood cell distribution width (RDW) as a simple and readily available marker in prostate cancer, as well as to evaluate RDW as a predictor of progression in prostate cancer patients. Materials and Methods: We evaluated 62 newly diagnosed prostate cancer patients who underwent transrectal ultrasound (TRUS)-guided biopsy and 62 healthy controls of mean age 64 (range, 45-75) years at the Urology Clinic of Bozok University Hospital. Data collection was performed using our laboratory information system database to retrieve findings regarding RDW, hemoglobin, prostatespecific antigen (PSA), and age. The RDW values were compared between the healthy control group and prostate cancer patients. A high risk of progression as defined as a Gleason score (GS) >6, total number of cores positive for cancer >33%, each core containing >50% cancer cells, and a prostate-specific antigen (PSA) level >10 ng/mL. Patients were classified according to risk of progression, as well as divided into subgroups according to the RDW quartile. Results: The mean RDW value of prostate cancer patients was 14.6, compared with 13.7 in the healthy control group (p=0.001). A higher RDW was associated with an increased risk of progression, whereas a lower RDW value was correlated with a low risk of progression. Conclusions: RDW is an easily derived measure that might, in combination with other markers, help predict prostate cancer risk and progression. We suggest that RDW may be used in combination with other parameters in the assessment of prostate cancer.

Cellulose Monoacetate/Tetraethyl Orthosilicate Hybrid Nanofibers for Electrochemical DNA Biosensors

Sinem Civan,Seval Aydin,Nilay Aladag Tanik,Yakup Aykut 한국섬유공학회 2021 Fibers and polymers Vol.22 No.4

Cellulose monoacetate/tetraethyl orthosilicate (CMA/TEOS) hybrid nanofibers were produced with differentratios via electrospinning and used for guanine oxidation analysis in the single strand deoxyribonucleic acid (ssDNA)molecules by electrochemical method. Nanofiber (NF) diameters for pure CMA dramatically decreased from between 2.4 μ-306 nm to between 958-42 nm with addition of hydrochloric acid (HCl) catalyzer into the electrospinning solution. UniformCMA nanofibers morphologies transform to more defect structures containing particular structures with the addition andincrease of TEOS content in CMA electrospinning solution. Also, nanofibers' diameters range became more fluctuated formand ultrafine nanofibers (diameters below 100 nm) existed more in the nanofiber mat. Even though the melting point wasseen at CMA nanofibers, melting points were not detectable in CMA/TEOS NFs since TEOS addition does not allow anappropriate crystallization. Thermal analysis results revealed that residual contents after TGA measurement in nitrogenatmosphere were gradually increased by increasing TEOS ratio in CMA/TEOS nanofibers. ssDNA molecules were immobilizedon the as-spun nanofibers and differential pulse voltammetry (DPV) measurements were carried out to investigate theguanine oxidation in ssDNA. Guanine oxidation signal intensities decreased with the initial addition of TEOS to CMAnanofibers and increases again by increasing TEOS content in CMA/TEOS hybrid nanofibers and then gradually decreasesagain with increasing TEOS content. The prepared CMA/TEOS hybrid nanofibers could be a promising candidate as anelectrode interface for genetic molecule detection via electrochemical methods.

Prognostic Factors in Oligodendrogliomas: a Clinical Study of Twenty-Five Consecutive Patients

Atalay, Tugay,Ak, Hakan,Celik, Bahattin,Gulsen, Ismail,Seckin, Hakan,Tanik, Nermin,Albayrak, Sedat Baki,Bavbek, Murad Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13

Background: The purpose of this study was to evaluate the prognostic significance of Ki-67 and subjective microvascular density (SMVD) indexes together with other factors in patients with oligodendroglioma. Materials and Methods: In this retrospective study, oligodendroglioma specimens obtained from twenty-five consecutive patients were evaluated for Ki-67 and SMVD indices to help determine histological grading and investigate the fidelity of these markers in clinical prognosis. Other potentially prognostic factors were Karnofsky performance scale, tumor histological grade, and adjuvant radiotherapy. Results: The Ki-67 proliferation index appeared to have a strong correlation with the grade of the tumor and the survival. Age, gender, adjuvant radiotherapy, surgical resection type (complete versus incomplete) did not have any influence on recurrence. The SMVD index correlated significantly with the 3 to 5-year survival. Conclusions: Ki-67 and MVD indexes are important and useful markers in estimating the prognosis of oligodendrogliomas.

Levels of Serum Trace Elements in Renal Cell Carcinoma Cases

Pirincci, Necip,Gecit, Ilhan,Gunes, Mustafa,Kaba, Mehmet,Tanik, Serhat,Yuksel, Mehmet Bilgehan,Arslan, Harun,Demir, Halit Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Trace elements which are essential components of biological structures may also be toxic when present at levels above the amounts required for biological function. In our study, trace element levels were measured with furnace atomic absorption spectrophotometry in 33 newly diagnosed renal cell carcinoma cases (preoperative) and 32 healthy controls. When compared with the control group, it was found that the levels of cadmium (Cd), lead (Pb) were higher and the levels of zinc (Zn), iron (Fe) and manganese (Mn) were lower in the patient group. These changes may be important in the formation of renal cell carcinoma, a question which should be explored with postoperative comparative studies.