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Paolo Casadio,Francesca Guasina,Maria Rita Talamo,Roberto Paradisi,Ciro Morra,Giulia Magnarelli,Renato Seracchioli 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.4
Objective: To report hysteroscopic treatment combined with levonorgestrel-releasing intrauterine device (LNG-IUD) to treat women with early well differentiated endometrial cancer (EC) at high surgical risk. Methods: Nine women diagnosed with stage IA, grade 1 endometrioid EC which was contraindicated or refused standard treatment with external beam radiation therapy with or without brachytherapy were enrolled in our prospective study. Endo-myometrial hysteroscopic resection of the whole uterine cavity and the placement of LNG-IUD for 5 years was performed. Response rate, perioperative complications, and recurrence of disease were evaluated. Results: None had intra or post-operative complications and all were discharged no later than the third day of hospitalization. After 6 months from surgery, all the women showed a complete regression of the lesion. All the women completed the 5 years follow-up and in no case was detected sign of recurrence. Two women died for causes unrelated to the tumor or the ongoing therapy. Conclusion: The alternative treatment with endo-myometrial hysteroscopic resection and LNG-IUD in women with stage IA, grade 1 endometrioid EC showed initial encouraging outcomes in terms of effectiveness and safety.
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Kinetics calculation of fast periodic pulsed reactors using MCNP6
Z. Zhong,Y. Gohar,A. Talamo,Y. Cao,I. Bolshinsky,Yu N. Pepelyshev,Alexander Vinogradov 한국원자력학회 2018 Nuclear Engineering and Technology Vol.50 No.7
Fast periodic pulsed reactor is a type of reactor in which the fission bursts are formed entirely withexternal reactivity modulation with a specified time periodicity. This type of reactors could generatemuch larger intensity of neutron beams for experimental use, compared with the steady state reactors. Inthe design of fast periodic pulsed reactors, the time dependent simulation of the power pulse is majorlybased on a point kinetic model, which is known to have limitations. A more accurate calculation methodis desired for the design analyses of fast periodic pulsed reactors. Monte Carlo computer code MCNP6 isused for this task due to its three dimensional transport capability with a continuous energy library. Some new routines were added to simulate the rotation of the movable reflector parts in the timedependent calculation. Fast periodic pulsed reactor IBR-2M was utilized to validate the new routines. This reactor is periodically in prompt supercritical state, which lasts for ~400 ms, during the equilibriumstate. This generates long neutron fission chains, which requires tremendously large amount ofcomputation time during Monte Carlo simulations. Russian Roulette was applied for these very longneutron chains in MCNP6 calculation, combined with other approaches to improve the efficiency of thesimulations. In the power pulse of the IBR-2M at equilibrium state, there is some discrepancy betweenthe experimental measurements and the calculated results using the point kinetics model. MCNP6 resultsmatches better the experimental measurements, which shows the merit of using MCNP6 calculationrelative to the point kinetics model.
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