소아의 후두개에 발생한 과립 세포종 1예

오재규,박선주,유태현 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Granular cell tumors are relatively uncommon benign laryngeal lesions, especially in children. The granular cell tumor can occurs everywhere in our body. Half of all granular cell tumors occur in the head and neck, with a third of these occuring in the tongue. The larynx is relatively uncommon location, accounting for approximately 7% to 10% of all reported cases. Typically, the most common presenting symptom is hoarseness, with some patients also presenting stridor, hemoptysis, dysphagia. But the tumor may be asymptomatic and be discovered only incidentally during a routine examination. Confirmative diagnosis should be made histopathologically and supported by immunohistochemical staining using S-100. Treatment of a granular cell tumor is complete excision with an attempt to maintain normal structures. We experienced a 14-year-old woman with laryngeal granular cell tumor, which involves the epiglottic lower margin. She was successfully treated with complete excision under laryngomicroscopic dissection. So we report it with a review of literatures.

편도 절제술 후 출혈에 관한 임상적 분석

오재규,박선주,유태현 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Background and Objectives : Hemorrhage is one of the most common complication after tonsillectomy. Despite of many various efforts, it still remains unsolved problem to many otolaryngologist. Because so many factors are related to postoperative bleeding after tonsillectomy, so we tried to see the postoperative hemorrhage rate in relation to various parameters. Material and Methods : A retrospective study on patients who had underwent tonsillectomy in Wallace Memorial Baptist Hospital for 6 years from January 2002 to December 2007. Parameters such as sex, seasons of year, age distribution, tonsil size, previous tonsillitis history and anesthesia type were considered. Results : Overall hemorrhage rate was 2.6%. Postoperative hemorrhage was common in adult males with incidence of 4.5% and most of them was secondary hemorrhage. In age distribution, the incidence was high in the group of 16~30 year. Bleeding was common in autumn, grade II tonsil and increased when the history of tonsillitis was frequent, and local tonsillectomy was better in terms of bleeding compared with tonsillectomy under general anesthesia. but there was no statistical significance. Conclusion : To reduce the incidence of postoperative hemorrhage, perioperative education and complete bleeding control during operation is important for high risk patients.

HLA-DPB1 유전자 형별법 개발

김태규,이혜정,정서영,정태준,한훈 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1

연구배경: HLA-DP 유전자는 DR 및 DQ와 같이 항원제공 세포(APCs), B 세포 및 활성화된 T 세포등의 표면에 발현되는 class Ⅱ 유전자로서 외인성 항원제공시 MHC 제한(restriction)과정을 통해 면역 반응에 관여한다. DP 항원 분자는 PLT(primed lymphocyte test)와 같은 세포학적 방법에 의해 처음으로 규명되었고, 이어서 혈청학적 형별이 시도되었으나, DR, DQ 분자에 비해 발현 정도가 낮아 형별에 어려움이 있었다. 최근 DP 유전자의 염기서열이 밝혀짐에 따라 DNA 수준에서 DP 형별이 가능하게 되었으며, 지금까지 DPA1 10개, DPBI 77개의 대립유전자가 밝혀졌다. 본 연구는 이식의 결과 및 질병 발생과 연관이 있다고 추정되는 HLA-DPB1 대립유전자를 DNA 수준에서 형별하고 정상 한국인의 DP 대립유전자 분포를 확인하기 위해 시도되었다. 방법: HLA-DPB1 유전자 중 초가변부위(hypervari-able region)가 있는 exon 2 부위를 일차적으로 증폭시킨후, 17종의 probe를 사용하여 PCR-SSOP를 실시하였고, PCR-SSP에는 5종의 primer를 사용하였다. 이들 방법은 DP형이 알려진 미국 UCLA 대학의 international cell exchange sample 88개를 표준 DNA 시료로 이용하여 확립하였다. 결과: 36종류의 HLA-DPBI 대립유전자를 형별할수 있음을 확인하였다. 그러나 DPBI*0402와 0601 대립유전자를 동시에 갖는 heterozygote인 경우에는 DPBI*0201와 2001을 동시에 갖는 heterozygous와 구분이 어려웠다. 100명의 정상 한국인에서 DPBI 대립 유전자형의 분포를 조사한 결과 한국인에서는 11종류의 HLA-DP 대립유전자가 존재함을 확인하였고, DPBI*0501(36.5%), 0201(27%), 0402(10.5%) 대립유전자의 순으로 분포되어 있었으며 검출율은 100%였다. 결론: 이상의결과로 골수 이식 등 이식시 공여자와 수혜자간의 조직적합성은 HLA-DP, DQ뿐만 아니라 DP도 확인 하게되었으며, 앞으로 질병과의 연관성 연구에서 이용될수 있을것으로 사료된다. Background: The HLA-DP genes are highly polymorphic, which encode heterodimeric cell surface glycoproteins that play a role in the immune response as restriction elements in antigen presentation. HLA-DP antigens were initially defined through the primed lymphocyte test (PLT), and the serological typing has been performed which is practically difficult because the expression of DP molecules is very low, comparing with that of DR and DQ. Recently, DNA sequencing and PCR have allowed the various and extensive study on the HLA-DP genes. We developed the molecular typing method for HLA-DPBI alleles, and studied the distribution in normal Korean population. Methods: After PCR amplification of hypervariable exon 2 regions in HLA-DPBI gene, both PCR-SSOP (sequence specific oligonucleotide probes) with 17 probes and PCR-SSP (sequence specific primers) by 5 Primers were used. And this method was tested using a international pannel DNA as standard. Results: Total 36 alleles of HLA-DPBI were defined in the standard DNA pannel. However, DPBI*0.402, and 0601 heterozygote could not be distinguished from DPBI*0201 and 2001 heterozygote. And 11 alleles were defined in 100 normal Koreans and the common alleles were DPBI*0501 (36.5%). 0201 (27%) and 0402 (10.5%). The detection rate was 100% in this study. Conclusion: As the results, the molecular typing of HLA-DPBI alleles is possible for the accurate matching between donor and recipient in born marrow transplantation and for the study of disease association.

신용정책분석이론

이태규 충남대학교 경상대학부설 경영경제연구소 1983 경영논집 Vol.5 No.2

고전 작가 연구의 방법론적 고찰

전규태 연세대학교 국어국문학과 1969 연세국문학 Vol.2 No.-

The Investment Size Matter with the Kelly Criterion

김규태 조선대학교 지식경영연구원 2008 기업과 혁신연구 Vol.1 No.2

대부분의 투자자들이 생각하듯이 투자 규모의 크기와 이익성이 선형적 관계를 이루고 있다는 고정적 관념이 사실일까? 이러한 일반적 관념에 반하여 본 연구에서 논하게 될 켈리기준에 의하면 투자 규모의 크기와 이익성 상호간에는 선형적 관계가 아닌 비선형적 관계가 성립된다고 한다. 켈리기준의 비선형적 관계성을 염두에 둔다면 투자자들은 투자 할당문제에 있어서 매우 신중한 투자활동을 취해야 할 것이다. 즉, 특정한 투자 자산에 대한 투자의 수익성을 극대화하기 위한 최적의 투자 할당액이 얼마이어야 하는지를 모든 투자자들은 결정해야 한다. 최적의 투자할당 문제를 다루는 것이 켈리기준의 궁극적인 목표라고 할 수 있다. 투자의 규모의 크기와 수익성의 상호관계성에 대한 켈리기준의 새로운 개념이 1956년에 주요 학회지에 발표되었음에도 불구하고 아직까지 이와 관련된 연구를 지속적으로 수행하고 있는 그룹은 극소수의 연구자들로 구성되어 있을 뿐이고 금융학 분야에서도 아직 심도있게 연구가 진행되고 있지 않고 있다. 이러한 사실로 인하여 본 연구에서는 켈리기준이 무엇이고 어떻게 실현되는지를 수리적 예제를 통하여 보여주고 있다. 그리고 다양한 종류의 켈리기준을 이해하기 쉽게 단계적으로 수리적 모형을 유도하였고 특히 Aristotle의 켈리기준을 확장하여 새로운 켈리기준을 소개하고 있다. 마지막으로 삼성전자와 현대자동차의 주식을 토대로 구성된 사례연구를 통하여 켈리기준의 실질적 사용예를 보여주고 있다. 그 결과는 일반적으로 수용될 수 있는 자본 할당률 범위 내에서 최적의 투자 할당액이 존재하지 않는 것으로 판명되었다. As currently most of investors suppose, is it true that there exists an outrightly linear relationship between the investment size and profitability?. On the contrary to the general conception about the relationship, the Kelly criterion which will be discussed in this paper says that such a relationship is destroyed in a real investment world. With this assertion in mind, the investors should be careful to make a decision on the investment size. That is, they should be concerned with how much must be made to maximize the profitability of their investment. It is also inferred from the assertion that there must be an optimal amount of the investment size to maximize the profitability. Finding this optimal point is one of the major objectives of the Kelly criterion. Even though the criterion was published in 1956 and had been regarded to provide a useful guideline for the investors, not only has it been studied by a extremely small group of the researchers, but it has also been rarely known to a finance community in a world. For these observations, this paper will discuss what the Kelly criterion is and illustrates it with a numerical example. Finally, it is concluded with the discussion of the future research directions, mainly oriented with the real investment case.

人體에서 分離한 葡萄糖 非醱酵菌의 抗菌劑 耐性에 關한 硏究

李淵台,崔承求,朴哲熙,曺圭鳳 단국대학교 대학원 1991 學術論叢 Vol.15 No.-

This experiment was conducted to classify for the 82 strains of glucose nonfermentative bacteria obtained from K hospital, in 1988, on the biological differentials and to test the resistance reaction on the drugs for those strains. The results were as follows : 1. Eighty two strains were classified into 65 strains of 79.3% of Ps. aeruginosa, 10 strains of 12.2% of Ps. cepacia, and 7 strains of 8.5% of Ac. calcoaceticus as results of 0 F sugar test, oxidase test, and DNase test. 2. It showed that Ps. aeruginosa was coincided with AP, CM, GM, KM, CF, and TC from the disk and MIC methods in the test of resistance reaction to antimicrobial agent, and especially, that AK and TOB KM and GM were observed high resistance reactive from MIC method. Resistnace to antibiotics for Ps. cepacia showed the identical reaction to AP, CB, CM, AK, SPT, CF, TC, TOB, KM and GM were observed high resistance reative from MIC method. Ac. calcoaceticus was identified the same resistance reaction to antibiotics to CB, KM, GM, AK, CF, and TOB, AP, SPT and TC showed high resistance reaction from the disk method. 3. CF and AP were observed the highest resistance reactions among 10 kinds of drugs used in this experiment and following was CM, KM and TC in order. 4. Ps. aeruginosa, Ps. cepacia, and Ac. calcoaeticus showed all multiple resistance reactions in the test of resistance to drugs, and Ps. aeruginosa was identified high resistance reaction to 6 drugs in 24.6%, Ps. cepacia was 9 drugs in 60%, and Ac. calcoaceticus showed resistance reaction to various kinds of drugs. 5. It showed important question in result of these studies that resistance percentage of NFB decreased by optimal antimicrobial selection and effective treatment established from serious antimicrobial treatment.

國文藝學 構造論 Ⅱ

全圭泰 연세대학교 인문과학연구소 1968 人文科學 Vol.20 No.-

This article treats the structure of the study of Korean literary arts, in addition to the article carried in the previous volume of this journal. It especially enters into the methodology of this specific field of study. An approach to this study, corresponding to the literary climate of this country and the nature and tradition of the nation, has been presented through an exploration of the character of the study of Korean literary arts in its relations to philology, comparative literature and the like. It is emphasized that the study of literary arts should by no means be included in that of the history of national literature nor should it be treated as an isolated study requiring specific methods. The study of Korean literary arts should be established as a more comprehensive and synthetic system in the methodical study of the history Korean national literature.

不確實性 條件에서 效率的市場假說의 限界

李泰奎 충남대학교 경상대학부설 경영경제연구소 1985 경영논집 Vol.7 No.1

무기고분자응집제를 이용한 조류의 응집제거

김규동,최영균,김희준,곽종운,정태학 대한상하수도학회 2002 상하수도학회지 Vol.16 No.5

An Experimental study was conducted for the removal of algae using various inorganic coagulants. Cultivation of algae, investigation of turbidity and chlorophyll-a removal efficiency according to the dosage of coagulants were conducted in series using a jar-tester in this study. Alum, PAC (Polyaluminum chloride), PAC-2 (Concentrated Polyaluminum chloride), PAC-Ca (PAC with Ca), PFC (Polyferricchloride) and PACS (Polyaluminum chlorinate silicate) with various SiO_2 content were used as coagulants. Algae grew up to about 1,500㎍ chlorophyll-a/l in 30 days. Cultivated algae was diluted to 150㎍ chlorophyll-a/l for the laboratory experiment. Decrease of pH was the lowest when PACS-5 was used as a coagulant, while it was the highest when PAC was used. Host of the coagulants showed high turbidity removal rate when the dosage was 1-3 mg Al/l. PFC showed stable turbidity removal efficiency and 80% of removal efficiency could be obtained when the dosage was 1.34 mg Fe/l. Among the coagulants, PACSs showed relatively higher removal efficiency of chlorophyll-a and it was the highest when PACS-5 was used. It means that inorganic coagulant including silicate is more advantageous in the removal of algae, and appropriate content of silicate on the basis of molar ratio of Al to Si is an important factor affecting the stability and settleability of the alum floc.