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홍택근,이용림,임무현,정낙현 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2004 한국식품저장유통학회지 Vol.11 No.1
솔잎의 기능성에 관한 연구를 위하여 솔잎발효추출물(PFE)과 에탄올추출물(PE 80, PE 50)로 효소적 저해활성과 아질산염 소거작용에 대하여 연구하였다. Tyrosinase의 저해효과는 솔잎발효 추출물인 PFE가 솔잎 에탄올 추출물 PE 80과 PE 50에 비해 약 5∼38%정도 저해활성 효과가 높게 나타났다. XOase 저해효과는 PFE가 62.77%, PE 80이 64.90%, PE 50이 55.91%의 저해율을 나타내였으며 ACE저해효과는 PFE가 78.02%, PE 80이 69.82%, PE 50이 21.75%의 순으로 솔잎발효 추출물인 PFE가 가장 높은 저해효과를 나타내었다. 아질산염 소거작용은 솔잎추출물 모두 pH 3.0이하에서 높은 분해능력을 나타내였다. 유기산 함량 분석 결과, PFE, PE 80, PE 50의 세 시료 모두 항산화작용에 관여하는 ascorbi acid가 가장 많이 함유되어 있었으며, 시료별 ascorbic acid의 함량은 솔잎 발효추출물인 PFE가 가장 많이 함유되어 있는 것으로 나타났다. Effects on the physiological functionality, such as tyrosinase, xanthine oxidase, angiotensin converting enzyme and Nitrite scavenging ability were also observed by pine needle fermentation extract(PFE) and the difference in the consistency of pine needle ethanol extracts(PE 80, PE 50) was found. In the inhibition effect on tyrosinase, PFEP showed 5-38% higher than that of PE 80 and PE 50. In the inhibition on XOase, PFE, PE 80 and PE 50 showed 62.77%, 64.390%, 55.91% respectively. In the inhibition effect on ACE, PFE, PE 80 and PE 50 showed 78.02%, 69.82% and 21.75% respectively. Among these, PFE showed the highest ACE inhibition effect. In the inhibition effect on nitrite scavenging anility, the pine needle extracts showed a high effect in pH 3.0. As the result of the research using HPLC for the organic and, all the samples(PFE, PE 80, PE 50) showed higher contents of the ascorbic acid concerned with the effect of the antioxidative. PFE showed the highest contents of the ascorbic acid.
Rim, Kyung-Taek,Song, Se-Wook,Kim, Hyeon-Yeong Occupational Safety and Health Research Institute 2013 Safety and health at work Vol.4 No.4
The use of nanoparticles (NPs) in industry is increasing, bringing with it a number of adverse health effects on workers. Like other chemical carcinogens, NPs can cause cancer via oxidative DNA damage. Of all the molecules vulnerable to oxidative modification by NPs, DNA has received the greatest attention, and biomarkers of exposure and effect are nearing validation. This review concentrates on studies published between 2000 and 2012 that attempted to detect oxidative DNA damage in humans, laboratory animals, and cell lines. It is important to review these studies to improve the current understanding of the oxidative DNA damage caused by NP exposure in the workplace. In addition to examining studies on oxidative damage, this review briefly describes NPs, giving some examples of their adverse effects, and reviews occupational exposure assessments and approaches to minimizing exposure (e.g., personal protective equipment and engineering controls such as fume hoods). Current recommendations to minimize exposure are largely based on common sense, analogy to ultrafine material toxicity, and general health and safety recommendations.
Rim, Tyler Hyung Taek,Nam, JaeSung,Kim, Eung Kweon,Kim, Tae-im Lippincott Williams Wilkins, Inc. 2013 Cornea Vol.32 No.7
PURPOSE:: To assess the sociodemographic and health-related risk factors associated with pterygium and its subtypes in Korea. METHODS:: From 2008 to 2010, a total of 14,920 randomly selected national representative participants of the Korean National Health and Nutrition Examination Survey underwent additional ophthalmologic examinations by the Korean Ophthalmologic Society. The risk factors for pterygium in general or according to subtype (atrophic, intermediate, and fleshy) were identified using multivariate logistic regression analysis. RESULTS:: The prevalence of pterygium was 6.7% (95% confidence interval, 5.9–7.5) in subjects aged 30 years or older. Older age, male sex, lower educational level, rural habitation, nonsmoking, and sun exposure were independent risk factors for pterygium. Among subjects with pterygium, older age, male sex, lower educational level, and nonsmoking were independent risk factors for all types of pterygium. Sun exposure for >5 h/d was the independent risk factor for the severe pterygium subtype. CONCLUSIONS:: Socioeconomic disparities in pterygium development exist. Proper ocular examination and education to avoid excessive sun exposure would be helpful in reducing disease risk.
( Taek Rim Yoon ),( Hyung Nam Kim ),( Kyung Soon Park ) 대한고관절학회 2012 Hip and Pelvis Vol.24 No.2
Ceramic-on-polyethylene components have better wear characteristics than metal-on-polyethylene components in total hip arthroplasty (THA), and thus, extensive wear resulting in penetration of the femoral head through the acetabular cup is rare after ceramic-on-polyethylene THA. However, several reports have been issued regarding catastrophic polyethylene failure in ceramic-on-polyethylene systems. Here, the authors report the first case of bilateral complete polyethylene wear failure with acetabular cup perforation after ceramic-on-polyethylene THA.
A Twenty-Eight Days Inhalation Toxicity Study of N-decane in Sprague Dawley Rats
Rim, Kyung Taek,Kim, Hyeon Young,Song, Kyung Seuk,Chung, Yong Hyun,Chang, Hee Kyung,Han, Jeong Hee,Lee, Sung Bae,Chun, Yoon Seok,Lee, Yong Mook,Yu, Il Je 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.4
N-decane은 지방족탄화수소로 다른 탄화수소들과 같이 혼합된 형태로 존재하며 페인트 제거제나 드라이 크리닝 제품에 사용된다 최근의 본 연구팀이 실시한 전자산업계의 MSDS 신뢰성조사 결과에 따르면 세정제의 사용 경향은 과거의 방향족 탄화수소나 CFC, HCFC에서 C_10 이상의 지방족탄화수소 물질로 변화되고 있는 경향을 보여주었다 Stoddard solvent나 나프타 같은 탄화수소 혼합물에 대한 작업 환경노출기준은 설정되어있지만 n-decane에 대해서는 제한적인 독성자료 밖에 없으며 작업환경노출기준은 설정되어 있지 않다 따라서 작업환경에 대한 적절한 관리기준제시와 독성학적 자료를 제공하기 위해 n-decane을 28일 반복 홉입독성시험을 실시하였다 6주령 흰쥐로 체중이 229±10g되는 숫컷과 165±7g되는 암컷 흰쥐를 4개 용량군 즉 대조군, 저농도군(50ppm), 중농도군(200ppm), 고농도군(800ppm)(각군당 10마리)으로 설정하여 하루 6시간, 주 5일로 4주간 홉입쳄버에서 노출시켰다 28일간 노출 후 n-decane의 노출용량에 따른 암수의 체중에는 유의한 변화가 없었으며 유의한 혈액학적 생화학적 변화도 발견되지 않았다 고농도로 노출된 수컷 몇 마리에서 고환 세정관에서의 공포화(vacuolization)가 발견되었으나, 간 신장, 비장, 폐, 부신, 심장, 뇌 등 다른 장기에 대한 조직병리학적 검사에서는 뚜렷한 조직병리학적인 변화를 발견할 수 없었다
Rim, Kyung-Taek,Kim, Soo-Jin Occupational Safety and Health Research Institute 2015 Safety and health at work Vol.6 No.3
Chemical mutagenicity is a major hazard that is important to workers' health. Despite the use of large amounts of allyl chloride, the available mutagenicity data for this chemical remains controversial. To clarify the mutagenicity of allyl chloride and because a micronucleus (MN) test had not yet been conducted, we screened for MN induction by using male ICR mice bone marrow cells. The test results indicated that this chemical is not mutagenic under the test conditions. In this paper, the regulatory test battery and several assay combinations used to determine the genotoxic potential of chemicals in the workplace have been described. Further application of these assays may prove useful in future development strategies of hazard evaluations of industrial chemicals. This study also should help to improve the testing of this chemical by commonly used mutagenicity testing methods and investigations on the underlying mechanisms and could be applicable for workers' health.