재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

흉선종 제거후에 발생한 재생 불량성 빈혈 : 증례보고

전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.

파인블랭킹 가공제품에 미치는 재료 및 비링의 영향

한규택 釜慶大學校 1998 釜慶大學校 論文集 Vol.3 No.2

The fine blanking is a process of pressworking which makes possible to produce thich sheet metal parts of finished sheared surface and close dimensional accuracy over whole material thickness in single blanking operation. Fineblanked parts in general are characterized by theri cleanly sheared surface over the whole stock thickness and accurate size for the specific functions. The fine blanking technology is urgently needed to remove secondary operations which are necessary in conventional blanking operation and cost reduction. In this study, the effect of material texture and vee-ring on the product is investigated by experimental observation and analysis.

12주간의 써키트 웨이트트레이닝이 중ㆍ장년기 남성의 건강관련체력에 미치는 영향

이규성,김문희,오경택,김범수 한국체육대학교 체육과학연구소 2000 韓國體育大學校附屬 體育科學硏究所論文集 Vol.19 No.1

The purpose of this study is to examine the change of health related physical fitness. The study conducted the experiment with 24 participants; three groups fo eight participants in each age group(40, 50 and 60's) The subjects are members of the G sports center. The results of this study are as followed. According to comprehensive results of the research, circuit weight training for 12 weeks appears to give a positive effects on middle aged men's health, and that large increase in body fat and lower strength is not an unavoidable result of aging but the result of an unhealthy life style. Putting the proper training for the middle-aged group into systematic and regular practice, exercise can delay the normal aging process and also maintain relative good health physiologically. I think we need to develop more rational and scientific exercise programs to build up physical strength and improve health.

미국 Rocky Mountain 국립공원 운영관리

류택규 圓光大學校 1996 論文集 Vol.32 No.2

본 논문은 최근 미국에 있어서 국립공원의 운영관리에 대한 정보를 얻기 위하여 1994년 미국 Colorado주 fortcollins에 있는 Colorado 주립대학교에 교환교수로 체제하면서 미국에서는 Yellowstone국립공원 다음으로 자연보전이 잘 되어 있으며 1년에 미국인을 비롯한 세계각국으로 Rocky Mountain의 자연식물과 동물들을 보기 위해서 300만명이 탐방하는 Rocky Mountain국립공원에 대해서 연구한 결과는 다음과 같다. 1. Rocky Mountain국립공원은 미국 중서부 멕시코에서 카나다까지 연결되는 Rocky 산맥의 3,000m 이상 고지대에 위치하며 1915년 1월 26일에 지정되었다. 2. 공원의 총면적은 1.067㎢로 서울의 605㎢에 대해 1.7배나 되는 광대한 면적을 차지하고 있으며 한 여름에도 정상에는 얼음이 덮여있고 이곳에서 발견되는 고유의 많은 고산식물과 산사슴, 산양 등이 서식하고 있다. 3. 공원내에서는 일체 취사를 할 수 없으며 쓰레기가 될 만한 것을 가저가지 않을 뿐아니라 버리지도 않고 있는 미국시민의 공원 이용태도를 본 받아야 한다 . 4. 공원관리인들은 공원내에 모든 정보에 대해서 너무나 잘 알고 있으며 최선을 다해서 탐방객을 다 안내하는 열의는 공원감시원에 불과한 공원관리인이 배워야 할 점이었다. 5. 우리국민들은 국립공원을 유원지로 착각하고 있는데 국립공원이란 후세에 그대로 물려줄 수 있는 유일한 자산이란 점을 인지하고 개발이 아닌 보전에 노력하여야 할 것이다. 6. 국립공원 운영관리를 담당 기관이나 직원만이 아닌 지역 사회단체, 자연애호가들이 참여하는 제도의 창출이 요구된다. 7. 미국의 국립공원은 내무부 일개국으로 직제가 편제되어 있는데 우리나라는 지역 경제과 1과 계업무로 취급하고 있는 것은 너무나 소홀히 취급하고 있는 바 개선해야할 점이다. This study was carried out to get information about guideline which managed the new style of the National park in U.S.A. To this I studied at Colorado State University near the Rocky Mountain National Park during one year in 1994. For this near the Rocky Mountain Nation Park I had to visited several times for observation and survey including interview with that Part staffs and visitors. The objects established national paerk is to protect nature culture, historical trace and beautiful scenery. Rocky Mountain National Park was not much exploied for an agriculture and a minery before destinated National Park. After 1916 it set up the Rocky Mountain National Park, the office for N.P. have been managed well continue to its intrinsic feature representatively in U.S.A. But it was not enough financial and manpowerful. In future we are increased more interesting important of the national park and must be support more money. Also all of us participate the N.P. management voluntarily for keep good N.P. It is our duty of modernized life and the way will be not debit in future generation. Keeping the nature could be find out our culture, traditional ethics and the history. It is the best way of nation government supply for future. I would like suggested few points to development plan for the National Park in Korea. 1. Organization on the National Park of Government system must be reorganize the improving its position activity. 2. National Park enlarges the national education area for the young people including build up museum. 3. National Park have to begins to guide of rescue in the park and arranges as a member National Park about export on the climbing of mountain or guide in a jungle wood. 4. biglcompany members concentrate interested is the National Park and charged on the support financial fund. 5. Every parks set up new commute including nature conservationist local members to develop of its park.

Arylnitrile imine의 1,3-Dipolar Cycloaddition 反應에 關한 硏究(Ⅰ)

朴澤奎 건국대학교 1975 學術誌 Vol.19 No.1

These studies aim at expanding the cycloaddition of nitrile imines among the 1,3-dipolar cycloaddition, and particularly at examining the 1,3-dipo1ar cycloaddition of arylnitrile imines. 3-trimethylsilylated 5-alkyl(or aryl) tetrazoles were obtained by reacting hexame-thyldisilazane with various 5-aryltetrazole. It was then thermolyzed to form C-alkyl(or aryl)-N-trimethylsilyl nitrile imines, in which the N-H proton of arylnitrne imines had been blocked by trimethylsilyl group, and was reacted with various amyl nitrites containing C-N group. As a result, the 1,3-dipolar cycloddition products, in which the N-position had been rimethyl silylated, were obtained. Various 3,6-diaryl-4H-1,2,4-triazole derivatives were synthesized by hydrolyzing the above products which accompanied the removal of trimethylsilyl group. The 4H-1,2,4-triazole derivatives thus prepared were identified with those made by the usual method by comparing the physical properties and I. R. spectra

중합효소연쇄반응을 이용한 HLA-C 유전자의 DNA Typing에 관한 연구

박택규 건국대학교 1997 學術誌 Vol.41 No.2

HLA-class I 유전자군에서 HLA-C 유전자는 세포표면의 발현율이 다른 class I 유전자에 비하여 매우 낮아, 혈청학적 방법으로 측정할 경우 20∼50%에서 blank로 측정되어 정착한 형별의 구분이 어려웠다. 이러한 점을 개선하기 위하여 본 연구에서는 중합효소연쇄반응(PCR)을 이용하여 HLA-C유전자의 DNA typing방법을 개발하였으며, 한국인에서 HLA-C 대립 유전자의 분포를 구하고자 하였다. 17종의 B-림프구 표준세포주의 DNA typing 결과는 과거에 발표된 것과 일치하였다. 50명에서 혈청학적 방법과 DNA typing을 동시에 실시하여 두 방법을 비교하였을 때, 두 검체에서 차이가 있었으나 split 항원임이 밝혀졌으며, 혈청학적 방법으로 검출되지 않은 24 blank 항원에서 유전자형으로는 모두 검출이 가능하였다. 한편 한국인에서 HLA-C대립 유전자 빈도를 보면 Cw*0101이 24.2%로 가장 높게 나타났으며, Cw*1401(16.3%)과 Cw0701* (11.7%) 대립 유전자도 17% 이상의 빈도를 나타내었다. 본 연구에서 개발한 중합효소연쇄반응을 이용한 HLA-C DNA typing방법은 시간이 짧고 방법이 간단하며, 특히 blank 항원을 완전히 규명할 수 있으므로 매우 효과적인 유전자 형별구분 방법으로 임상실험에서 장기기식이나 질환관련성 연구에 활용할 수 있을 것으로 기대된다. The molecular analysis and characterization of HLA-C allelic polymorphism has been impeded by lack of serological reagents which identify individual HLA-C antigens. To provide a better definition of the HLA-C alleles, we have developed DNA typing method using polymerase chain reaction-sequence specific primer (PCR-SSP) technique Instead of serological typing. DNA samples from 17 B-lymphoblstoid cell lines and 120 Korean individuals have been typed by DNA typing. The PCR-SSP results of control cell lines were correlated well with serology. Fifty Korean Individual samples determined by serological typing were compared with HLA-C DNA typing. Twenty four blank antigens were completely determined by DNA typing, In the population genetic study, Cw*0101 (24.2%) allele was the most frequent allele in Korean. Cw*1401 (16.3%) and Cw*0701 (11.7%) alleles were also frequently found. In conclusion, the high level of discrimination for HLA-C alleles may prove useful and informative in the study of transplant survival and identify the importance of allelic differences, not readily detectable by serology, on host and donor compatibility. Key Word : HLA-C, PCR-SSP, DNA typing

中國外債硏究

李圭澤 한국중국문화학회 2002 中國學論叢 Vol.14 No.-

모터사이클 엔진실린더의 호닝가공용 혼스톤에 관한 연구

한규택,장명진 釜慶大學校 1999 釜慶大學校 論文集 Vol.4 No.1

Grinding technology in modern industry society is focusing on research and development for grinding stone and mashining parts for the purpose of high accuracy and high efficiency of products. But, in order to equip the high technology and high accuracy of micro stone which is one of grinding stone, a continuous effort on R & D is required. In this study, the honing processing work of 2 cycle engine cylinder for motorcycle which has an open hole is carried out so as to investigate the boring and hone stone effects on accuracy of honing. As the experimental result of this study, we could conclude that it is possible to secure good conditions of honing by controlling and keeping appropriate cycle-time in the stage of boring for the prior step of honing.

국내 설계시공일괄사업에서 Fast-Track 적용결정 모델 : S월드컵주경기장 사례분석을 중심으로

조규만,현창택,구교진 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

The Fast Track is the Method for accelerating schedule through the activities that are normally done in series are done in parallel. But it should not have been effective in Public construction, because the owner did not have confidence to success the fast track project. so, this study proposes the model selecting the project that is more effective to apply fast track. The model is made up two factors; one is owner's organization and the other is each project's characteristics. The use of these model enable owner to provide the Guide Line of the rational making decision.