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유태현,한광협,박성하,김형길,문영명,한재호,조상호 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.2
Recent advances in both the diagnosis and treatment of hepatocellular carcinoma have improved the prognosis and changed the clinical significance of the recently increasing distant metastases. Distant metastases found after successful treament of the primary lesions are of great clinical significance for the treatment of hepatocellular carcinoma. The duodenum is a rare site of hematogenous metastases or direct invasion from hepatocellular carcinoma. A 23 year old man was admitted with upper gastrointestinal bleeding. He had been diagnosed with hepatocellular carcinoma and treated by a left lobectomy and chemoembolization. The patient was admittted for 12 months after the treatment of the primary tumor. Endoscopic examination revealed a mass in the duodenal bulb that protruded into the lumen. He died due to massive hematemesis. We report on a rare case of hepatocellular carcinoma with duodenal invasion in a 23-year-old male patient.
허근,김진숙,권태협,김정애,용철순,하정희,이동웅 영남대학교 약품개발연구소 1998 영남대학교 약품개발연구소 연구업적집 Vol.8 No.-
Gastrodia elata (GE) is a oriental medicinal herb which has been used traditionally for the treatment of various brain diseases including convulsion and epilepsy. In order to examine the mechanism of anticonvulsive effect, we treated the methanol extract of GE (500 mg/kg, P.O) to the pentylenetetrazole (PTZ)-induced convulsive rats. Methanol extracts of GE siginificantly inhibited (35%) the convulsion state as well as the level of lipid peroxidation (25%) in the brain. The ether fraction of methanol extracts among the others effectively inhibited in vitro lipid peroxidation dose dependently (5.0×10^(-6)~2.0×10^(-5) g/ml). The scavenging effect on hydroxy radicals was found in all the fractions of ether, butanol, and dichloromethane. These results suggest that the anticonvulsive effect of GE is possibly due to the antioxidative effects of the active components in GE.
Tae Hyub Hong(홍태협),Sang Won Lee(이상원),Hyeong Taek Kim(김형택) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
In the present study, a Computational Fluid Dynamics (CFD) analysis of the coolant flow in the containment pool is carried out and debris transportation is evaluated using the Lagrangian particle tracking method. The containment pool flow is simulated as a single-phase model and a two-phase model. In the single-phase model, the boundary representing a free surface is set to be a slip boundary condition. The two phase model uses Volume of Fluid (VOF) method. The transport of debris is calculated after achieving a steady state in the simulation of each model. The simulation results show that flow patterns are similar in both models, and the velocity magnitude calculated from the VOF model is less than that calculated from the single-phase model, in general.
Tae-Hyub Hong,Choeng-Ryul Choi,Chang-Nyung Kim 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.11
Human heart valves diseased by congenital heart defects, rheumatic fever, bacterial infection, cancer may cause stenosis or insufficiency in the valves. Treatment may be with medication but often involves valve repair or replacement (insertion of an artificial heart valve). Bileaflet mechanical heart valves (BMHVs) are widely implanted to replace the diseased heart valves, but still suffer from complications such as hemolysis, platelet activation, tissue overgrowth and device failure. These complications are closely related to both flow characteristics through the valves and leaflet dynamics. In this study, the physiological flow interacting with the moving leaflets in a bileaflet mechanical heart valve (BMHV) is simulated with a strongly coupled implicit fluid-structure interaction (FSI) method which is newly organized based on the Arbitrary-Lagrangian-Eulerian (ALE) approach and the dynamic mesh method (remeshing) in FLUENT. The simulated results are in good agreement with previous experimental studies. This study shows the applicability of the present FSI model to the complicated physics interacting between fluid flow and moving boundary.
Forest Canopy Density Estimation Using Airborne Hyperspectral Data
( Tae Hyub Kwon ),( Woo Kyun Lee ),( Doo Ahn Kwak ),( Tae Jin Park ),( Jong Yoel Lee ),( Suk Young Hong ),( Cui Guishan ),( So Ra Kim ) 대한원격탐사학회 2012 大韓遠隔探査學會誌 Vol.28 No.3
This study was performed to estimate forest canopy density (FCD) using airborne hyperspectral data acquired in the Independence Hall of Korea in central Korea. The airborne hyperspectral data were obtained with 36 narrow spectrum ranges of visible (Red, Green, and Blue) and near infrared spectrum (NIR) scope. The FCD mapping model developed by the International Tropical Timber Organization (ITTO) uses vegetation index (VI), bare soil index (BI), shadow index (SI), and temperature index (TI) for estimating FCD. Vegetation density (VD) was calculated through the integration of VI and BI, and scaled shadow index (SSI) was extracted from SI after the detection of black soil by TI. Finally, the FCD was estimated with VD and SSI. For the estimation of FCD in this study, VI and SI were extracted from hyperspectral data. But BI and TI were not available from hyperspectral data. Hyperspectral data makes the numerous combination of each band for calculating VI and SI. Therefore, the principal component analysis (PCA) was performed to find which band combinations are explanatory. This study showed that forest canopy density can be efficiently estimated with the help of airborne hyperspectral data. Our result showed that most forest area had 60 ~ 80% canopy density. On the other hand, there was little area of 10 ~ 20% canopy density forest.
이송되는 컵 내부의 자유 표면의 거동 특성에 대한 수치해석
홍태협(Tae Hyub Hong),채희문(Hee Moon Chae),김창녕(Chyang Nyung Kim) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5
A manipulator is operated for the motion of mechanical hands or arms by mechanical mechanism. When a cup including liquid inside is shifted by a manipulator, it is important to know how a free surface of the liquid moves. In this study, non-dimensional parameters have been found that affect the rise of the free surface in a cup moving with constant acceleration. The non-dimensional parameters are the dimensionless time, the ratio of inertia effect to vicous effect (Reynolds number), aspect ratio of the liquid inside the cup and acceleration ratio (Froude number). Through this study, the height of the free surface rise in a cup has been predicted. Generally the maximum rise of the free surface is dependent on the Reynolds number and Froude number strongly, but on the aspect ratio weakly. But the influence of the aspect ratio on the maximum rise of the free surface in not negligible in the range 10 < Re < 100.
김태현 ( Tae Hyeon Kim ),김진홍 ( Jin Hong Kim ),서동완 ( Dong Wan Seo ),이태훈 ( Tae Hoon Lee ),이상협 ( Sang Hyub Lee ),고동희 ( Dong Hee Koh ) 대한췌담도학회 2013 대한췌담도학회지 Vol.18 No.2
급성 췌장염은 임상의들이 흔히 진료할 수 있는 질환으로 임상적으로 경증에서 중증까지 다양하고, 중증의 경우에는 다발성 장기부전 및 사망에 이를 수 있는 치명적인 질환이다. 외국에서는 이 질환에 대한 가이드라인이 개발되어 사용되고 있지만, 국내에 적합한 급성 췌장염의 진단과 치료에 관한 가이드라인 없는 실정이다. 이에 대한췌담도학회에서는 급성 췌장염의 진료와 국민보건향상에 도움이 될 수 있는 가이드라인을 개발하였다. 가이드라인은 4분야 39개의 항목으로 구성되어 있다. 즉 4 분야는 급성췌장염의 진단(11개), 중증도 평가(6개), 초기치료(9개), 국소 합병증 및 괴사성 췌장염의 치료(13개)로 구성되었다. 본 고에서는 이 가이드라인의 소개에 앞서 가이드라인의 개발 목적과 과정 등을 소개하였다. Acute pancreatitis is a common and potentially lethal disease that is associated with significant morbidity and consumes enormous health care resources. There was still no the current domestic standard guidelines for acute pancreatitis. To provide a framework for clinicians to manage acute pancreatitis and to improve national health care, guidelines have been developed by the Korean Pancreatobiliary Association. These guidelines consisted of 39 consensus statements for the diagnosis (n=11), the assessment of the severity (n=6), initial management (n=9), the treatment of necrotizing pancreatitis and local complication (n=13) of acute pancreatitis were developed. In this article, we will describe the purpose and process of the formation of the guidelines.
OPR1000 원자로 격납건물 내 중대사고 시 수소 및 증기 거동에 대한 CFD 해석
홍태협(Tae Hyub Hong),최청열(Choengryul Choi),김형택(T. H. Kim) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
Hydrogen could be generated by an active reaction of the fuel-cladding and the steam in the reactor pressure vessel during a hypothetical severe accident in a nuclear power plant (NPP). In such situation, the generated hydrogen is released together with steam into the containment. In order to mitigate hydrogen hazards which could possibly occur in the NPP containment, a hydrogen mitigation system (HMS) is usually adopted, such as hydrogen igniters and passive autocatalytic recombiners (PAR). In this study, an analysis of the hydrogen and steam behavior has been numerically performed using fully 3-dimensional computational fluid dynamics (CFD) technique, during a total loss of feed water (LOFW) accident in the OPR1000 containment. During the accident, a huge amount of hot water, steam, and hydrogen are released into the containment. The possibilities of flame acceleration and a transition from deflagration to detonation (DDT) are evaluated by using the Sigma?ambda criteria.
Forest Canopy Density Estimation Using Airborne Hyperspectral Data
Kwon, Tae-Hyub,Lee, Woo-Kyun,Kwak, Doo-Ahn,Park, Tae-Jin,Lee, Jong-Yoel,Hong, Suk-Young,Guishan, Cui,Kim, So-Ra The Korean Society of Remote Sensing 2012 大韓遠隔探査學會誌 Vol.28 No.3
This study was performed to estimate forest canopy density (FCD) using airborne hyperspectral data acquired in the Independence Hall of Korea in central Korea. The airborne hyperspectral data were obtained with 36 narrow spectrum ranges of visible (Red, Green, and Blue) and near infrared spectrum (NIR) scope. The FCD mapping model developed by the International Tropical Timber Organization (ITTO) uses vegetation index (VI), bare soil index (BI), shadow index (SI), and temperature index (TI) for estimating FCD. Vegetation density (VD) was calculated through the integration of VI and BI, and scaled shadow index (SSI) was extracted from SI after the detection of black soil by TI. Finally, the FCD was estimated with VD and SSI. For the estimation of FCD in this study, VI and SI were extracted from hyperspectral data. But BI and TI were not available from hyperspectral data. Hyperspectral data makes the numerous combination of each band for calculating VI and SI. Therefore, the principal component analysis (PCA) was performed to find which band combinations are explanatory. This study showed that forest canopy density can be efficiently estimated with the help of airborne hyperspectral data. Our result showed that most forest area had 60 ~ 80% canopy density. On the other hand, there was little area of 10 ~ 20% canopy density forest.
원자로 외벽 냉각에서의 상변화 열전달 및 이상유동에 대한 수치해석
홍태협(Tae-Hyub Hong),최유정(Yu Jung Choi),이상원 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
The hypothetical scenario of a severe accident with core meltdown and formation of a melt pool in the lower plenum of the reactor pressure vessel (RPV) can result in the failure of the RPV and the discharging of the melt to the containment. One accident management strategy could be the stabilization of the RPV by cooling the outside vessel wall with water. This is the concept of IVR-ERVC. The purpose of this study offers detailed information on complex thermal hydrodynamic phenomena, including boiling and two-phase flows, in APR1400 for IVR-ERVC. The thermal hydrodynamic phenomena are simulated using a computational fluid dynamics (CFD) technique with a phase change heat/mass transfer approach for boiling and the volume of fluid (VOF) approach for two-phase flows. The simulation results give a better understanding on the natural circulation mechanism of cooling water, boiling and two-phase flows in this system. Also, this study provides quantitative data such as natural circulation flow rates and heat transfer coefficients in different cooling water temperatures.