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Tae-Dong Jeong,박찬정,Hyoeun Shim,장성수,Hyun-Sook Chi,Dok Hyun Yoon,김대영,이정희,이제환,서철원,이규형 대한혈액학회 2012 Blood Research Vol.47 No.4
Background Flow cytometric immunophenotyping has been used to identify neoplastic plasma cell populations in patients with multiple myeloma (MM). Previous reports have described the use of several antigens, including CD38, CD138, CD56, CD117, CD52, CD19 and CD45, to distinguish distinct populations of plasma cells. The aim of this study was to evaluate a simplified immunophenotyping panel for MM analysis. Methods A total of 70 patients were enrolled in the study, 62 of which were newly diagnosed with MM (untreated), whereas the remaining 8 were undergoing bone marrow assessment as part of follow-up after treatment (treated). Treated cases included 3 patients with relapse and 5 patients with persistence of MM. Multiparametric flow cytometric immunophenotyping was performed using monoclonal antibodies against CD56, CD19, CD138 (CD38), and CD45. Results In differential counts, plasma cells in bone marrow (BM) accounted for 3.6‒93.2% of the total nucleated cell count. The positive expression rates of CD56, CD19, CD138, and CD45 in neoplastic myeloma cells were 83.9%, 0%, 98.4%, and 37.1%, respectively, among the 62 untreated cases, and 75.0%, 0%, 87.5%, and 37.5%, respectively, among the 8 treated cases. CD19 expression of neoplastic plasma cells was negative in both untreated and treated cases. Conclusion The simplified immunophenotyping panel, CD56/CD19/CD138(CD38)/CD45, is useful for distinguishing neoplastic myeloma cells from reactive plasma cells in clinical practice. In addition, CD19 represents the most valuable antigen for identifying neoplastic myeloma cells in patients with MM.
Woo, Tae Gyun,Cha, Byeong Jun,Seo, Hyun Ook,Kim, Young Dok Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.458 No.-
<P><B>Abstract</B></P> <P>Poly(3-hexylthiophene-2,5-diyl) (P3HT) is an organic semiconducting polymer that is widely used in organic electronic devices such as organic solar cells. In this work, we studied the oxidation behavior of P3HT on glass under exposure to visible light and dry air. We also compared the oxidation behavior of bare P3HT films with that of P3HT/phenyl-C<SUB>61</SUB>-butyric acid methyl ester (PCBM) bulk heterojunction systems consisting of donor and acceptor. UV–Vis absorption spectroscopy and X-ray photoelectron spectroscopy were employed to provide evidence that optically excited P3HT could undergo oxidation, which was likely initiated via electron transfer from the conduction band of P3HT to O<SUB>2</SUB>, forming strongly oxidizing O<SUB>2</SUB> <SUP>–</SUP> species. By contrast, P3HT + PCBM yielded almost no oxidation of organic materials under the same conditions. PCBM was thus suggested to extract optically excited electrons from P3HT, thereby inhibiting the formation of O<SUB>2</SUB> <SUP>–</SUP>. PCBM thus played a role in separating electron-hole pairs from the photoactive layers of organic solar cells and affected the passivating oxidation of photoactive conjugate polymers.</P> <P><B>Highlights</B></P> <P> <UL> <LI> P3HT, a semiconductive polymer, is easily oxidized by visible light under air. </LI> <LI> Oxidizing agent of P3HT is O<SUB>2</SUB> <SUP>–</SUP> formed by electron transfer from P3HT to O<SUB>2</SUB>. </LI> <LI> PC<SUB>61</SUB>BM, an electron acceptor, passivates oxidation of P3HT. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>