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Sidrat, Tabinda,Kong, Rami,Khan, Abdul,Idrees, Muhammad,Xu, Lianguang,El Sheikh, Marwa,Joo, Myeong-Don,Lee, Kyeong-Lim,Kong, Il-Keun MDPI AG 2020 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.21 No.1
<P>Sex-related growth differences between male and female embryos remain an attractive subject for reproductive biologists. This study aimed to investigate the endogenous factors that play a crucial role in the pace of early development between male and female bovine embryos. Using sex pre-selected semen by Y-specific monoclonal antibodies for the production of bovine embryos, we characterized the critical endogenous factors that are responsible for creating the development differences, especially during the pre-implantation period between male and female embryos. Our results showed that at day seven, (57.8%) Y-sperm sorted in vitro cultured embryos reached the expanded blastocyst (BL) stage, whereas the X-sperm sorted group were only 25%. Y-BLs showed higher mRNA abundance of pluripotency and developmental competency regulators, such as Oct4 and IGF1-R. Interestingly, Y-sperm sorted BLs had a homogeneous mitochondrial distribution pattern, higher mitochondrial membrane potential (∆Ѱm), efficient OXPHOS (oxidative phosphorylation) system and well-encountered production of ROS (reactive oxygen species) level. Moreover, Y-blastocysts (BLs) showed less utilization of glucose metabolism relative to the X-BLs group. Importantly, both sexes showed differences in the timing of epigenetic events. All these factors directly or indirectly orchestrate the whole embryonic progression and may help in the faster and better quality yield of BL in the Y-sperm sorted group compared to the X counterpart group.</P>
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( Abdullah Yasar ),( Amtul Bari Tabinda ),( Uzma Shahzadi ),( Pakeeza Saleem ) 한국화학공학회 2014 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.52 No.5
The main focus of this study was the evaluation of arsenic concentration in the ground water of Lahore atdifferent depth and application of different mitigation techniques for arsenic removal. Twenty four hours of solar oxidationgives 90% of arsenic removal as compared to 8 hr. or 16 hr. Among oxides, calcium oxide gives 96% of Asremoval as compared to 93% by lanthanum oxide. Arsenic removal efficiency was up to 97% by ferric chloride, whereas95% by alum. Activated alumina showed 99% removal as compared to 97% and 95% removal with bauxite and charcoal,respectively. Elemental analysis of adsorbents showed that the presence of phosphate and silica can cause a reductionof arsenic removal efficiency by activated alumina, bauxite and charcoal. This study has laid a foundation forfurther research on arsenic in the city of Lahore and has also provided suitable techniques for arsenic removal.
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Abdullah Yasar,Sadia Khalil,Amtul Bari Tabinda,Afifa Malik 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.1
The study investigated the efficiency and cost effectiveness of solar-assisted photochemical processes in comparison with advance oxidation processes (AOPs) for the textile effluents treatment. Efficiency of UV irradiation alone for one hour in removing color was almost double in comparison to solar radiation alone for effluents of different dye concentrations (E1>E2>E3). For coupled UV/H2O2 process, there was higher color removal efficiency obtained for effluent E3 (85%) as compared to E2 (70%) and E1 (57%), while E1 showed higher COD removal efficiency (70%) as compared to E2 (50%) and E3 (62%). However, the efficiency of solar/H2O2 for COD removal was comparable to UV/ H2O2, i.e., E2 (57%) and E3 (53%). In the case of UV and solar-assisted photo-Fenton processes, removal efficiency of the UV process was further increased as approached to almost 90% removal for E1; on the other hand, the solar-assisted process efficiency remained the same. The relative efficiencies of AOPs were found to be in the order of UV assisted photo-Fenton process>UV/H2O2>UV alone. Although, solar-assisted Fenton treatments were relatively low and slow but without any energy consumption in comparison to high energy consumption of UV. Among the UV processes, UV assisted photo-Fenton treatment appeared to have better color removal efficiency with energy requirements of 5 kWh/m3, 8 kWh/m3 and 3 kWh/m3 for E1, E2 and E3, respectively.
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Ali Sadia Basharat,Mahmood Khalid,Saeed Raheel,Salman Tabinda,Choudhary Muhammad Iqbal,Haleem Darakhshan Jabeen 한국독성학회 2021 Toxicological Research Vol.37 No.2
Omeprazole (OM) is one of the most prescribed drugs worldwide for the treatment of hyperacidity and gastric reflux. However, concerns regarding its safety have emerged recently, and the drug is reported to enhance the risk for anxiety and cognitive deficits, particularly in elderly patients. The present study investigated these adverse effects, if any, in adult male rats. Associated changes in brain serotonin (5-hydroxytryptamine; 5-HT) and dopamine metabolism and the expression of 5-HT-1A receptors in the raphe and hippocampus were also determined. The drug was injected i.p. in doses of 10 and 20 mg/ kg for 15 days. Both doses of OM decreased motor activity in an open field and impaired learning and memory in the Morris water maze test. Anxiety monitored in an elevated plus maze test was enhanced in rats treated with 20 mg/kg OM only. The levels of 5-HT and its metabolite 5-hydroxyindoleacetic acid and of homovanillic acid, a metabolite of dopamine, determined by HPLC-EC, were decreased in the brain of OM treated rats. The expression of 5-HT-1A receptor, determined by qRT-PCR, was reduced markedly in the hippocampus and moderately in the raphe. Our results provide evidence that OM use can reduce raphe hippocampal serotonin neurotransmission to lead to anxiety/depression and cognitive impairment. There is a need for increased awareness and prescription guidelines for therapeutic use of OM and possibly also other proton pump inhibitors.
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Idrees, Muhammad,Xu, Lianguang,El Sheikh, Marwa,Sidrat, Tabinda,Song, Seok-Hwan,Joo, Myeong-Don,Lee, Kyeong-Lim,Kong, Il-Keun MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.23
<P>The PPARs (peroxisome proliferator-activated receptors) play critical roles in the regulation of lipid and glucose metabolism. PPARδ, a member of the PPARs family, is associated with decreased susceptibility to ectopic lipid deposition and is implicated in the regulation of mitochondrial processes. The current study aimed to determine the role of PPARδ in fatty acid β-oxidation and its influence on PEPCK for the lipogenic/lipolytic balance during in vitro bovine oocyte maturation and embryo development. Activation of PPARδ by GW501516, but not 2-BP, was indicated by intact embryonic PEPCK (cytosolic) and CPT1 expression and the balance between free fatty acids and mitochondrial β-oxidation that reduced ROS and inhibited p-NF-κB nuclear localization. Genes involved in lipolysis, fatty acid oxidation, and apoptosis showed significant differences after the GW501516 treatment relative to the control- and 2-BP-treated embryos. GSK3787 reversed the PPARδ-induced effects by reducing PEPCK and CPT1 expression and the mitochondrial membrane potential, revealing the importance of PPARδ/PEPCK and PPARδ/CPT1 for controlling lipolysis during embryo development. In conclusion, GW501516-activated PPARδ maintained the correlation between lipolysis and lipogenesis by enhancing PEPCK and CPT1 to improve bovine embryo quality.</P>
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